Determinación de la clonalidad en tejidos humanos
DOI:
https://doi.org/10.17533/udea.iatreia.v28n3a05Palabras clave:
cáncer, inactivación del cromosoma x, leucemia, linfoma, reordenamiento génicoResumen
Las proliferaciones malignas suelen ser clonales. La mayoría de las veces el potencial de una lesión se establece por medio del análisis clínico y el estudio anatomopatológico, pero algunos casos son de difícil diagnóstico. Por otra parte, existen situaciones en las que se producen clonas dominantes cuyo análisis es importante, tal como ocurre en enfermedades autoinmunes e inmunodeficiencias. Este artículo presenta de manera comprensible las técnicas principales para el estudio de la clonalidad, a saber: la evaluación de los reordenamientos génicos del receptor de antígeno y la evaluación del gen del receptor de antígeno humano.
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