Determinación de la clonalidad en tejidos humanos

Autores/as

  • Nicolás Villamizar-Rivera Instituto Nacional de Cancerología
  • Natalia Olaya Instituto Nacional de Cancerología

DOI:

https://doi.org/10.17533/udea.iatreia.v28n3a05

Palabras clave:

cáncer, inactivación del cromosoma x, leucemia, linfoma, reordenamiento génico

Resumen


Las proliferaciones malignas suelen ser clonales. La mayoría de las veces el potencial de una lesión se establece por medio del análisis clínico y el estudio anatomopatológico, pero algunos casos son de difícil diagnóstico. Por otra parte, existen situaciones en las que se producen clonas dominantes cuyo análisis es importante, tal como ocurre en enfermedades autoinmunes e inmunodeficiencias. Este artículo presenta de manera comprensible las técnicas principales para el estudio de la clonalidad, a saber: la evaluación de los reordenamientos génicos del receptor de antígeno y la evaluación del gen del receptor de antígeno humano. 

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Biografía del autor/a

Nicolás Villamizar-Rivera, Instituto Nacional de Cancerología

Licenciado en Biología, Coordinador del proyecto de investigación Estudio de la clonalidad linfoide por medio del análisis de reordenamientos del receptor del antígeno. Grupo Patología Oncológica, Instituto Nacional de Cancerología, E.S.E. Bogotá Colombia. 

Natalia Olaya, Instituto Nacional de Cancerología

Doctora en Ciencias. Patóloga, Médica Especialista. Instituto Nacional de Cancerología. E.S.E. Bogotá Colombia.

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Publicado

2015-07-03

Cómo citar

1.
Villamizar-Rivera N, Olaya N. Determinación de la clonalidad en tejidos humanos. Iatreia [Internet]. 3 de julio de 2015 [citado 4 de diciembre de 2022];28(3):269-82. Disponible en: https://revistas.udea.edu.co/index.php/iatreia/article/view/18969

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