Diagnostic validity of five clinical prediction scales for deep vein thrombosis (DVT)
DOI:
https://doi.org/10.17533/10.17533/udea.iatreia.131Keywords:
Ambulatory Care, Colombia, Deep Venous Thrombosis, Hospitalization, Validation StudyAbstract
Introduction: The deep vein hrombosis (DVT) is a common entity that mainly affects the deep venous system of the lower limbs, for which ultiple clinical prediction scales have been developed, which have been constructed and validated in outpatients and inpatients.
Objetives: We aimed to validated five clinical prediction scores for the diagnosis of lower limb DVT in patients
from La Sabana de Bogota, Colombia.
Methods: A cross-sectional study with analysis of a diagnostic test was carried out in patiens with suspected deep vein thrombosis, including those who had venous Doppler ultrasound of the lower limbs for suspected DVT. The performance of five clinical prediction scales for DVT (classic and modified Wells, Oudega, CEBI and Constans) for outpatients and inpatients was calculated in those scores who are validated in both populations and only in ambulatory or hospitalized patients for those that are specific scores.
Results: Nine hundred seventy-four patients were entered into the analysis, of which 485 (49.7%) presented DVT. The Constans scale had a better iagnostic performance among inpatients and outpatients with an area under the ROC curve of 0.73 (95% 0.70-0.78) when compared with classic Wells, modified Wells, Oudega and CEBI. When we compared Constans performance in both groups of patients separately, we observed better performance with respect to the other scores.
Conclusion: The Constans scale presents a better diagnostic performance compared to the other scales when applied to inpatients and outpatients.
Downloads
References
(1) Moumneh T, Penaloza A, Roy PM. Trombosis venosa profunda. EMC - Tratado Med. 2018 Mar;22(1):1–6. DOI 10.1016/S1636-5410(17)87867-3.
(2) Kafeza M, Shalhoub J, Salooja N, Bingham L, Spagou K, Davies AH. A systematic review of clinical prediction scores for deep vein thrombosis. Phlebology. 2017 Sep;32(8):516-531. DOI 10.1177/0268355516678729.
(3) Olaf M, Cooney R. Deep Venous Thrombosis. Emerg Med Clin North Am. 2017 Nov;35(4):743-770. DOI 10.1016/j.emc.2017.06.003.
(4) Dennis R, Arboleda MN, Rodríguez MN, Salazar M, Posada P. Estudio nacional sobre tromboembolismo venoso en población hospitalaria en Colombia. Acta Med Colomb. 1996;21:55–63.
(5) Wells PS, Anderson DR, Bormanis J, Guy F, Mitchell M, Gray L, et al. Value of assessment of pretest probability of deep-vein thrombosis in clinical management. Lancet. 1997 Dec 20-27;350(9094):1795-8. DOI 10.1016/S0140-6736(97)08140-3.
(6) Oudega R, Moons KG, Hoes AW. Ruling out deep venous thrombosis in primary care. A simple diagnostic algorithm including D-dimer testing. Thromb Haemost. 2005 Jul;94(1):200-5. DOI 10.1160/TH04-12-0829.
(7) Alper EC, Ip IK, Balthazar P, Piazza G, Goldhaber SZ, Benson CB, Lacson R, Khorasani R. Risk Stratification Model: Lower-Extremity Ultrasonography for Hospitalized Patients with Suspected Deep Vein Thrombosis. J Gen Intern Med. 2018 Jan;33(1):21-25. DOI 10.1007/s11606-017-4170-3.
(8) Constans J, Boutinet C, Salmi LR, Saby J-C, Nelzy M-L, Baudouin P, et al. Comparison of four clinical prediction scores for the diagnosis of lower limb deep venous thrombosis in outpatients. Am J Med. 2003 Oct;115(6):436–40.
(9) Zakai NA, Wright J, Cushman M. Risk factors for venous thrombosis in medical inpatients: validation of a thrombosis risk score. J Thromb Haemost. 2004 Dec;2(12):2156-61. DOI 10.1111/j.1538-7836.2004.00991.x.
(10) Silveira PC, Ip IK, Goldhaber SZ, Piazza G, Benson CB, Khorasani R. Performance of Wells Score for Deep Vein Thrombosis in the Inpatient Setting. JAMA Intern Med. 2015 Jul;175(7):1112-7. DOI 10.1001/jamainternmed.2015.1687.
(11) Schouten HJ, Koek HL, Oudega R, van Delden JJ, Moons KG, Geersing GJ. Validation of the Oudega diagnostic decision rule for diagnosing deep vein thrombosis in frail older out-of-hospital patients. Fam Pract. 2015 Feb;32(1):120-5. DOI 10.1093/fampra/cmu068.
(12) Nisio MD, Es N van, Büller HR. Deep vein thrombosis and pulmonary embolism. The Lancet. 2016 Dec 17;388(10063):3060–73. DOI 10.1016/S0140-6736(16)30514-1.
(13) Donnellan E, Khorana AA. Cancer and Venous Thromboembolic Disease: A Review. Oncologist. 2017 Feb;22(2):199-207. DOI 10.1634/theoncologist.2016-0214.
(14) Gruettner J, Viergutz T, Bolte M, Henzler T, Schoenberg SO, Sudarski S, et al. Importance of risk factors for the evaluation of patients with a suspected pulmonary embolism. Exp Ther Med. 2015 Jun;9(6):2281-2284. DOI 10.3892/etm.2015.2395.
(15) Sermsathanasawadi N, Suparatchatpun P, Pumpuang T, Hongku K, Chinsakchai K, Wongwanit C, et al. Comparison of clinical prediction scores for the diagnosis of deep vein thrombosis in unselected population of outpatients and inpatients. Phlebology. 2015 Aug;30(7):469-74. DOI 10.1177/0268355514541981.
Additional Files
Published
How to Cite
Issue
Section
License
Copyright (c) 2021 Universidad de Antioquia
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
Papers published in the journal are available for use under the Creative Commons license, specifically Attribution-NonCommercial-ShareAlike 4.0 International.
The papers must be unpublished and sent exclusively to the Journal Iatreia; the author uploading the contribution is required to submit two fully completed formats: article submission and authorship responsibility.