Characterization of Medication-Related Problems and Negative Outcomes within the Framework of an Academic Activity in Two University Hospitals in Bogota, Colombia
DOI:
https://doi.org/10.17533/udea.iatreia.346Keywords:
Drug Interactions, Drug-Related Side Effects and Adverse Reactions, Health Education, Medication Errors, PharmacovigilanceAbstract
Introduction: Pharmacovigilance focuses on the detection, assessment, understanding, and prevention of adverse drug reactions or any related problems.
Objectives: To conduct a pharmacovigilance exercise within an academic activity to characterize drug-related problems (DRP) and adverse drug reactions (ADR).
Methods: A descriptive cross-sectional study was conducted with patients from two university hospitals through an academic activity involving undergraduate medical students. DRPs and ADRs were identified and analyzed according to the Third Granada Consensus. Drug–drug interactions (DDIs) were described, and the World Health Organization (WHO) causality algorithm for adverse reactions was applied. Reports were submitted to the pharmaceutical service.
Results: Between 2019 and 2021, 92 patients were included. A total of 580 DDIs and 357 non-DDI DRPs were identified, as well as 263 ADRs, of which 15.3% were related to necessity, 14.2% to effectiveness, and 71.5% to safety. ADRs were classified as definite (1.5%), probable (20.9%), possible (76.8%), and improbable (0.76%); 40% of these were reported.
Conclusions: Academic and research activities can strengthen students’ competencies in identifying medication-related risks. DRPs and ADRs are very frequent during hospitalization, often go unnoticed, and represent a significant risk to patients.
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