Determinación de Helicobacter spp. en cerdos en el departamento de Antioquia, Colombia


  • Bernardo J. Rodriguez
  • Diego Aranzazu
  • Laura C. Ortiz



Gastrospirillum suis, Helicobacter Heilmannii, Helicobacter pylori, immunohistochemistry, swine gastric ulcer



Swine as well as human naturally harbor Helicobacter spp. and frequently develop gastroesophagic ulcer (GEU). Nowadays in Colombia there are no reports of natural colonization or infection by Helicobacter spp. in swine. The aim of this study investigation was to verify the presence of Helicobacter spp. in ulcerated and preulcerated lesion in the gastric mucosa of pigs and to typify to the different stages of the lesion. This research was carried out in 275 ulcerated, 15 erosioned and 15 normal stomachs obtained from Medellin abattoir at the State of Antioquia, Colombia. The analysis of the results was made by using descriptive statistic. A Z test was used to establish differences between proportions with a level of confidence of 95%. This paper report for the first time in Colombia the natural colonization of porcine stomach by Helicobacter spp. and discuss some aspects of the pathogenesis of GEU.


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Akopyants NS, Eaton KA, Berg DE. Adaptative mutationAdaptative mutation and colonization during Helicobacterpylori infection of gnotobiotic piglets. Infect Immun1995; 63:116-121. [Abstract] [HTML] [Pdf]

Argenzio RA, South Worth M. Sites of organic acid production and absorption in the gastrointestinal tract of the pig. Am J Physiol1975; 228:454-460. [Abstract]

Banks WJ. Histología veterinaria aplicada. 2nd ed. México: Manual Moderno; 1996.

Barbosa AJ, Silva JC, Nogueira AM, Paulino E, Miranda CR. Higher incidence ofHigher incidence of Gastrospirillum sp. in swine with gastric ulcer of the pars oesophagea. Vet Pathol 1995; 32:134-139. [Abstract]

Blackshaw JK, Kelly WR. Effects of gastric ulceration on growth rate of intensively reared pigs. Vet Rec1980; 106:52-54. [Abstract]

Borén T, Falk P. Helicobacter pylori binds to blood group antigens. Science Medi. 1994; 1:28-37. [Abstract]

Cantel F, Magras C, Marais A, Federighi M, Megraud F. Helicobacter species colonizing pig stomach: molecular characterization and determination of prevalence. Appl Environ Microbiol 1999; 65:4672-4676. [Abstract] [ HTML] [Pdf]

Curtin T, Goetsch GD, Hollandbeek R. Clinical and pathological characterization of oesophagogastric ulcer in swine. J Am Vet Med Assoc 1963; 143: 854-860.

Davies PR. Gastric ulcer in pigs and humans: comparative aspects of etiology and risk factor. In: Proc AD Leman Swine Conf, Univ Minnesota 1995;129-138.

De-Grote D, Van-Dorn LJ, Ducatelle R, Verschuuren A, Haesebrouck F, et al. “Candidatus“Candidatus Helicobacter suis”, a gastric helicobacter from pigs, and its phylogenetic relatedness to other gastrospirilla. Int J Bacteriol 1999; 4:1769-1777. [Abstract]

Eaton KA, Morgan DR, Krakowka S. Campylobacter pylory virulence factors in gnotobiotic piglets.Infect Immun 1989; 57:1119-1125. [Abstract] [HTML] [Pdf]

Eaton KA, Morgan DR, Krakowka S. Motility as factor in the colonization of gnotobiotic piglets by Helicobacter pylori. J Med Microbiol 1992; 37:123-127.

Eaton KA, Radin MJ, Krakowka S. An animal model of gastric ulcer due to bacterial gastric in mice. Vet Pathol1995; 32:489-497. [Abstract]

Fawcett PT, Gibney KM, Vinette KM. Helicobacter pylori can be induced to assume the morphology of Helicobacter heilmannii.J Clin Microbiol 1999; 37:1045-1048. [Abstract] [HTML] [Pdf]

Fox JG, Dangler CA, Sager W, Borkowski R, Gliato JM. Helicobacter mustelaeassociated gastric adenocarcinoma in ferrets (Mustelae putorius furo).Vet Pathol 1997; 34:125-129. [Abstract] [ HTML] [ Pdf]

Fox JG, Yan LL, Dewhirst FE, Paster BJ, Shames B, et al. Helicobacter bilis sp . nov.,a novel Helicobacter species isolated from bile, livers, and intestines of aged, inbred mice. J Clin Microbiol1995; 32:445-454. [Abstract] [ HTML] [ Pdf]

Fox JG, Dewhirst FE, Tully JG, Paster BJ, Yan L, et al. Helicobacter hepaticus sp. a microaerophilic bacterium isolated from livers and intestinal mucosa scrapings from mice. J Clin Microbiol 1994; 32:1238-1245. [Abstract] [HTML] [Pdf]

Genta RM, Gürer IE, Graham DY, Krishnan B, Segura AM, et al. Adherence of Helicobacter pylori to areas of incomplete intestinal metaplasia in the gastric mucosa. Gastroenterol 1996; 111:1206-1211. [Abstract]

Graham DY, Go MF. Helicobacter pylori: estado actual. Infectología 1994; 14:65-69.

Hill JE, Khanolkar SS, Stadtländer CT. Gastric ulcer associated with a Helicobacter- like organism in Jaguar (Felis concolor). Vet Pathol 1997; 34:50-51. [Abstract] [HTML] [Pdf]

Kelly SM, Pitcher MCL, Farmery SM, Gibson GR. Isolation of Helicobacter pylori from feces of patients with dyspepsia in the United Kingdom. Gastroenterol1994; 107:1671-1674. [Abstract]

Krakowka S, Eaton KA, Rings DM. Occurrence of gastric ulcer in gnotobiotic piglets colonized by Helicobacter pylori. Infec Immun 1995; 63:2352-2355. [Abstract] [HTML] [Pdf]

Krakowka S, Eaton KA, Rings DM, Argenzio RA. Production of gastroesophageal erosions and ulcer (GEU) in gnotobiotic swine monoinfected with fermentative commensal bacteria and fed high-carbohydrate diet. Vet Pathol1998; [35:274-282. [Abstract] [ HTML] [ Pdf]

Krakowka S, Morgan DR, Kraft WG, Leunk RD. Establishment of gastric Campylobacter pylori infection in the neonatal gnotobiotic piglet. Infect Immun 1987; 55:2789-2796. [Abstract] [HTML] [Pdf].

Makinde MO, Obwolo MJ. Abattoir survey of gastric ulcer in pigs in Zimbabwe. Zimb VetZimb VetJ1990; 21:116-123. [Abstract]

Mendes EN, Queiroz DM, Rocha GA, Moura SB, Leite VH, et al. Ultraestructure of a spiral microorganismUltraestructure of a spiral microorganism from pig gastric mucosa “Gastrospirillum suis”. J Med Microbiol 1990; 33:61-66. [Abstract]

Mesa RC. Avances sobre Helicobacter pylori. En: Universidad de Antioquia (eds). Tópicos de infectología. Medellín: Universidad de Antioquia; 1994. p.87-96.

Morgan DR, Fox JG, Leunk RD. Comparison of isolates of Helicobacter pylori and Helicobacter mustelae. J Clin Microbiol 1991; 29:395-397. [Abstract] [HTML] [Pdf]

Morgner A, Lehn N, Andersen LP, Thiede C, Bennedsen M, et al. Helicobacter heilmannii-Associated primary gastric low-grade MALT lymphoma: complete remission after curing the infection. Gastroenterology 2000; 118:821-828. [Abstract]

O’Brien JJ. Gastric ulcer. In: Leman AD. Disease of Swine. 6thed. Ames: Iowa state University Press; 1986. p.725-736.

Otto G, Hazell SH, Fox JG, Howlett CR, Murphy JC, et al. Animal and public health implications of gastric colonization of cats by Helicobacter-like organism. JJClin Microbiol1994; 32:1043-1049. [Abstract] [HTML] [Pdf]

Queiroz DM, Rocha GA, Mendes EN, Lage AP, Carvalo AC, et al. A spiral microorganism in the stomach of pig. Vet Microbiol 1990; 24:199-204. [Abstract]

Queiroz DM, Rocha GA, Mendes EN, De Moura SB, Rocha AM, et al. Association betweenAssociation between Helicobacter and gastric ulcer disease of the pars oesophagea in swine. Gastroenterol 1996; 111:19-27. [Abstract]

Reis JC, Sobestiansky J, Mores N, Emilz M. Úlcera gástrica como causa de Morte e como achado de necropsia em três rebanhos suínos. Arq Bras Med Vet Zoot 1991; 43:525-533. [Abstract]

Rocha GA, Queiroz DM, Mendes EN, Lage AP, Barbosa AJ. Simple carbolfuchsin staining for demonstratingSimple carbolfuchsin staining for demonstrating C. pylori and other spiral bacteria on gastric mucosa. J ClinPathol 1989; 42:1004-1005. [Abstract] [HTML] [Pdf]

Rodríguez BJ, Aranzazu D, Valencia F, Franco OI, Ortiz LC. Frecuencia de lesiones gástricas halladas post mortem en cerdos de la ciudad de Medellín (Colombia). Rev Colomb Cienc Pecu 2008; 21:219-227. [Abstract] [HTML] [Pdf]

Sierra F, Pabón D. Helicobacter pylori: un dogma que nace. Med Lab1997; 7:425-439. [Abstract]

Vaira D, Ferron R, Negrini R, Cavazzini J, Holron C, et al. Detecion of Helicobacter pylori like organism in the stomach of some food-source animal using a monoclonal antibody. Ital J Gastroenterol 1992; 24:118-184. [Abstract]

Wesley YV, Suarez D. Recovery of Helicobacter-like organism from slaughterhouse swine. Res Invest Report1996; 1:1-6. [Abstract]

Yeomans ND, Kolt SD. Helicobacter heilmannii (formerly Gastrospirillum): Association with pig and human pathology. Gastroenterol1996; 111:244-247. [Abstract]




How to Cite

Rodriguez, B. J., Aranzazu, D., & Ortiz, L. C. (2009). Determinación de Helicobacter spp. en cerdos en el departamento de Antioquia, Colombia. Revista Colombiana De Ciencias Pecuarias, 21(2), 9.



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