Effects of corn oil on the gastric mucosa of horses with induced ulcer

José R Martínez; Angelica M Zuluaga; Geraldo E Silveira

doi:10.17533/udea.rccp.324973

Autores

José R Martínez Universidad de Antioquia
Angelica M Zuluaga Universidad de Antioquia
Geraldo E Silveira Universidade Federal de Minas Gerais

DOI:

https://doi.org/10.17533/udea.rccp.324973

Palavras-chave:

antioxidante-oxidante, estômago, fenilbutazona, prostaglandina

Resumo

a síndrome de úlcera gástrica equina (SUGE), tem natureza multifatorial, atingindo ambas mucosas. A terapêutica exige várias estratégias com períodos longos de medicação. Objetivo: avaliar os efeitos do óleo de milho (OM) em equinos com úlceras gástricas induzidas, com descrição dos mecanismos na reparação da mucosa. Métodos: quinze equinos foram utilizados em três grupos. Na indução das úlceras foi utilizado o confinamento e a fenilbutazona. Após avaliação gastroscópica e exame de laboratório, os animais foram tratados, o grupo controle, (grupo I), recebeu sucralfato (SA), entanto nos grupos II e III se administrou OM em dose de 70-90 mL/100 Kg. Foram realizadas gastroscopias, colheita de conteúdo gástrico e biópsia da área glandular da mucosa para análise de: prostaglandina E₂ (PGE₂), pH, parâmetros antioxidantes e oxidantes. Resultados: lesões gástricas de intensidade leve a moderadas foram induzidas nas áreas glandular e não glandular da mucosa. Entre os principais resultados encontrados foram o reestabelecimento dos parámetros antioxidantes, a inibição da enzima oxidante mieloperoxidase (MPO) e uma leve alteração na PGE₂. Conclusão: o OM só teve efeito terapêutico na área glandular similar aos efeitos do SA.

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