The first, the next, and the cinematographed versions of AZT
DOI:
https://doi.org/10.17533/udea.vitae.20030Abstract
“Ronald Woodroof died of AIDS in September 12, 1992, seven years after he was diagnosed. A lower dose of AZT became widely used in later drug combinations that saved millions of lives”. These words end the film Dallas Buyers Club, a recent, highly awarded movie, that tells the true story of a cowboy diagnosed with AIDS in 1985 and illegally receives the firsthand antiviral AZT but, due to the severe side effects that the drug afflicted, begins to experiment with – and illicitly distribute among the “Club” – non-FDA approved remedies in search of a better treatment for himself and other AIDS patients. Perhaps owing to an artistic strategy, the movie waits until the last couple of lines to do justice to AZT and the impact it had in dealing with AIDS at that day and age.
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Bergmann W, Feeney RJ. Contributions to the study of marine products. XXXII. The nucleosides of sponges. J Org Chem. 1951; 16 (6): 981-987
Cohen, SS. Sponges, cancer chemotherapy, and cellular aging. Perspect Biol Med. 1963; 6 (2): 215-227
Evans JS, Musser EA, Mengel GD, Forsblad KR, Hunter JH. Antitumor activity of 1-beta-D-arainofuranosylcytosine hydrochloride. Exp Biol Med. 1961; 106(2): 350-353
Cimino G, De Rosa S, De Stefano S. Antiviral agents from a gorgonian, Eunicella cavolini. Experientia. 1984; 40(4): 339-340
Privat de Garilhe M, de Rudder J. Effect of 2 arbinose nucleosides on the multiplication of herpes virus and vaccine in cell culture. C R Hebd Seances Acad Sci. 1964; 259: 2725-2728
Elion GB, Furman PA, Fyfe JA, Miranda P, Beauchamp L, Schaeffer HJ. Selectivity of action of an antiherpetic agent, 9-(2-hydroxyethoxymethyl)guanine. Proc Natl Acad Sci USA. 1977; 74 (12): 5716-5720
Horwitz JP, Chua J, Noel MJ. The monomesylates of 1-(2-deoxy-bd-lyxofuranosyl) thymines. Org Chem Ser Monogr. 1964; 29 (7): 2076-2079
Mitsuya, H., Weinhold, K. J., Furman, P. A., St. Clair, M. H., Nusinoff-Lehrman, S., Gallo RC, Bolognesi D, Barry DW, Broder S. 3’-Azido-3’-deoxythymidine (BW A509U): an antiviral agent that inhibits the infectivity and cytopathic effect of human T-lymphotropic virus type III/lymphadenopathy-associated virus in vitro. Proc Natl Acad Sci USA. 1985; 82: 7096-7100.
Gómez-Archila LG, Zapata W, Galeano E, Martínez A, Diaz F, Rugeles MT. Bromotyrosine derivatives from marine sponges inhibit the HIV-1 replication in vitro. Vitae. 2014; 21(2): 44-55.
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