Toxicological impact of rabeprazole and evaluation of toxic effects on the plant-based eukaryotic test models

Authors

  • Muhammad Torequl Islam Bangabandhu Sheikh Mujibur Rahman Science and Technology University https://orcid.org/0000-0001-6392-3820
  • Marcello Iriti Department of Agricultural and Environmental Sciences, Milan State University, via G. Celoria 2, Milan 20133, Italy https://orcid.org/0000-0002-5063-1236
  • Hicham Harhar Laboratory of Materials, Nanotechnology and Environment, Faculty of Sciences, Mohammed V University in Rabat, Av. Ibn Battouta, B.P1014, Rabat, Morocco https://orcid.org/0000-0001-8266-0130
  • Youssef Elouafy Laboratory of Materials, Nanotechnology and Environment, Faculty of Sciences, Mohammed V University in Rabat, Av. Ibn Battouta, B.P1014, Rabat, Morocco https://orcid.org/0000-0002-0441-2913
  • Imane Chamkhi Laboratory of Materials, Nanotechnology and Environment, Faculty of Sciences, Mohammed V University in Rabat, Av. Ibn Battouta, B.P1014, Rabat, Morocco https://orcid.org/0000-0002-5865-7713
  • Eda Sönmez Gürer Sivas Cumhuriyet University, Faculty of Pharmacy, Department of Pharmacognosy, Sivas, Turkey
  • Javad Sharifi-Rad Centro de Estudios Tecnológicos y Universitarios del Golfo, Veracruz, Mexico https://orcid.org/0000-0002-7301-8151

DOI:

https://doi.org/10.17533/udea.vitae.v31n2a352429

Keywords:

Rabeprazole, Allium cepa, Allium sativum, Cicer arietinum, Toxicity monitoring tools

Abstract

Background: Rabeprazole (RPZ), a widely used proton pump inhibitor, is known to have toxic effects on human beings.
Objective: To evaluate the current understanding of its toxicological effects on humans and animals, a literature and laboratory-based study was conducted.
Methods: A comprehensive search of published literature was conducted in various databases up until April 2020, using specific keywords. Additionally, toxic effects of RPZ-Na (0.025-0.4 mM) were evaluated on Allium cepa, Allium sativum and Cicer arietinum at different exposure times using CuSO4 as a reference standard.
Results: The literature review revealed that RPZ has a wide range of side effects including nausea, vomiting, diarrhea, headache, rhinitis, myalgia, pharyngitis, abdominal pain, dyspepsia, and eye disorders. Chronic exposure to RPZ has also been associated with significant biochemical and hematological alterations, as well as various toxicological effects such as hypergastrinemia, hyperplasia, atrophy of gastric glands, gastric anti-secretory effect, and hypochlorhydria. The laboratory analysis showed that RPZ-Na concentration-dependently inhibited root length of A. cepa and A. sativum, as well as shoot and root lengths of C. arietinum.
Conclusions: This study highlights the toxicological impacts of RPZ and its formulations on human and animals. Results suggest that RPZ-Na has a concentration-dependent toxic effect on A. cepa, A. sativum, and C. arietinum. Therefore, it is important to take adequate precautions during its long-term use.

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Adaption towards the toxic effects of the test sample and controls on Allium cepa

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Published

27-09-2024

How to Cite

Torequl Islam, M., Iriti, M., Harhar, H., Elouafy, Y., Chamkhi, I., Gürer, E. S., & Sharifi-Rad, J. (2024). Toxicological impact of rabeprazole and evaluation of toxic effects on the plant-based eukaryotic test models. Vitae, 31(2). https://doi.org/10.17533/udea.vitae.v31n2a352429

Issue

Vol. 31 No. 2 (2024)

Section

Pharmacology and Toxicology

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Copyright (c) 2024 Muhammad Torequl Islam, Marcello Iriti, Hicham Harhar, Youssef Elouafy, Imane Chamkhi, Eda Sönmez Gürer, Javad Sharifi-Rad

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