EFFECT OF HYDRAZONES AGAINST INTRACELLULAR AMASTIGOTES OF Leishmania panamensis AND A PARASITIC CYSTEIN PROTEASE

Authors

  • Diana L. MUÑOZ
  • Diana P. CARDONA
  • Álvaro CARDONA
  • Lina M. CARRILLO
  • Winston QUIÑONES
  • Fernando ECHEVERRI
  • Iván D. VÉLEZ
  • Sara M. ROBLEDO

Keywords:

sìntesis, hidrazonas, efecto leishmanicida, proteasas de cisteìna, Leishmania (V) panamensis, synthesis, hydrazones, leishmanicidal effect, cystein proteases

Abstract


In this paper, the synthesis of hydrazones derived from cromano, thiocroman, alkyl and aril hydrazones

is described, as well as their leishmanicidal activity and their effect on cysteine proteases from L.

(V) panamensis. A series of novel phenylthiochromane and benzyl and naphtyl derivatives are synthesized and evaluated for their cytotoxic and antileishmanial activities. Their effect on parasite cysteine protease is also evaluated. Only phenylthiochromane derivatives display some activity against Leishmania (V) panamensis but all compounds are inactive against parasitic cystein protease. These results may suggest a different mechanism of action for these compounds.

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Published

2009-02-04

How to Cite

MUÑOZ, D. L., CARDONA, D. P., CARDONA, Álvaro, CARRILLO, L. M., QUIÑONES, W., ECHEVERRI, F., VÉLEZ, I. D., & ROBLEDO, S. M. (2009). EFFECT OF HYDRAZONES AGAINST INTRACELLULAR AMASTIGOTES OF <I>Leishmania panamensis</I> AND A PARASITIC CYSTEIN PROTEASE. Vitae, 13(2). Retrieved from https://revistas.udea.edu.co/index.php/vitae/article/view/548

Issue

Section

Pharmacology and Toxicology

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