DEVELOPMENT AND VALIDATION OF AN ANALYTICAL METHODOLOGY FOR COCAINE HYDROCHLORIDE DETERMINATION IN A SYNTHETIC POLYMER BY ULTRAVIOLET SPECTROMETRY

  • Dorelly A. BONILLA Q.
  • Luisa F. PEÑUELA B.
  • Noralba SIERRA M.
  • Josías E. DÍAZ F.
  • Jaime H. ROJAS B.
Keywords: Cocaine, polymer, reverse high performance liquid chromatography, C18, UV detection

Abstract

An ultraviolet spectrometry method was developed for the quantitative assay of cocaine hydrochloride in

a latex plastic polymer. The absorption was determined in sulfuric acid 0,5N at 233 nm, after substance

extraction using the same acid. Selectivity, linearity between 4 and 20 ppm and good reproducibility were

shown by this method. Detection and quantification limits were 1,6 and 4,0 ppm, respectively. Method

robustness was also verified, as well as cocaine hydrochloride stability in sulfuric acid 0,5N, medium

where the samples and reference standards were stored. These properties, besides its simplicity and

accuracy, make it suitable for achieving proposed objectives. The validated method was applied to the

determination of cocaine hydrochloride in polymer confiscated by the law

|Abstract
= 7 veces | PDF (ESPAÑOL (ESPAÑA))
= 40 veces|

Downloads

Download data is not yet available.
Published
2009-02-16
How to Cite
BONILLA Q. D. A., PEÑUELA B. L. F., SIERRA M. N., DÍAZ F. J. E., & ROJAS B. J. H. (2009). DEVELOPMENT AND VALIDATION OF AN ANALYTICAL METHODOLOGY FOR COCAINE HYDROCHLORIDE DETERMINATION IN A SYNTHETIC POLYMER BY ULTRAVIOLET SPECTROMETRY. Vitae, 15(1). Retrieved from https://revistas.udea.edu.co/index.php/vitae/article/view/772
Section
Pharmacology and Toxicology