INHIBITORY ACTIVITY OF SOME MARINE SPONGE EXTRACTS FROM URABÁ GULF ON DIHYDROFOLATE REDUCTASE ENZYME

  • Diego A. ZABALA
  • Bibiana ECAVARRÍA
  • Alejandro MARTÍNEZ
Keywords: Dihydrofolate reductase, metotrexate®, marine sponges.

Abstract

Dihydrofolate reductase is an enzyme involved in the production of pyrimidinic base timidin, a structural

component of DNA, therefore whatever substance that inhibit this enzyme inhibit the DNA synthesis as

a consequence and it can be potentially useful as a treatment of several types of cancer like lymphoblastic

leukemias. In this work we determinate the inhibition grade that the ethanol extracts from Colombian

marine sponges: Svenzea zeai, Amphimedon compressa, Ircinia campana, Aplysina archeri, Xestospongia proxima y

Xestospongia muta, over the human purified enzyme dihydrofolate reductase. The results shown that most

of marine sponge extracts inhibite the enzyme. Results are compared with methotrexate® a medicament

used against cancer which is used as a control for the bioassays. Results demonstrate that some of the

analyzed extracts have more inhibition than the control metotrexate®.

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Published
2009-02-17
How to Cite
ZABALA D. A., ECAVARRÍA B., & MARTÍNEZ A. (2009). INHIBITORY ACTIVITY OF SOME MARINE SPONGE EXTRACTS FROM URABÁ GULF ON DIHYDROFOLATE REDUCTASE ENZYME. Vitae, 15(2). Retrieved from https://revistas.udea.edu.co/index.php/vitae/article/view/802
Section
Natural Products