ASOCIACION ENTRE DROGAS RECIBIDAS POR LA MADRE EN EL PRIMER TRIMESTRE DEL EMBARAZO Y LA PRESENCIA DE LABIO LEPORINO Y/O PALADAR HENDIDO EN EL RECIEN NACIDO
PRUEBA PILOTO
Abstract
Cleft lip is a cleft that affects not only the lip but also the primary palate; cleft palate refers only to a cleft located in the secondary palate. Being the two processes different from the anatomical point of view, they can present together constituting “cleft palate with cleft lip”.
There is abundant embryological evidence that both conditions are different degrees of the same defect; nevertheless many investigators have concluded that cleft palate alone appears to be a separate disease. No definitive studies have been done on both processes and there is only tentative evidence that environmental as well as genetic factors are involved in causing cleft palate or cleft lip. Family and twin studies indicate the existence of very complex but specific predispositions as the cause of most of the malformations. In cleft palate and cleft lip, ten to fifty percent of the cases are associated with genetic factors. In relation to the latter factors it has been shown that cleft palate with cleft lip shows a strong familial tendency and a higher concordance rate in monozygotic twins than in dizygotic twins. Family studies show that the condition is more frequent in close relatives of an affected individual than in distant relatives.
Other studies in families indicate that from a genetic point of view cleft palate alone and cleft palate with cleft lip appear to be etiologically distinct.
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References
Carter, C.O. "Las malformaciones congénitas" Crónica de la OMS (Ginebra) 21(7): 306-312, Julio 1967
"Los factores genéticos en las malformaciones congénitas". Crónica de la OMS (Ginebra) 24(6): 267-272, Junio 1971.
Jiménez, Estella R., Consuelo E. Agrebo y Mabel T. Foppiano. "Consideraciones generales de teratogenicidad". Salud 4. Argentina (Buenos Aires) (2): 9-18, 1971.
Organización mundial de la salud. Factores genéticos y malformaciones congénitas; informe de un grupo científico de la OMS. (Ginebra), 1970 48p. (OMS Serie de Informes Técnicos, 438).
Warkany, Josef. Congenital malformations; facial anomalities, Chicago, year Book Medical Publishers, 1971. p.p. 621-638.
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