Dengue y embarazo en Antioquia, Colombia

Authors

  • Berta Nelly Restrepo Universidad de Antioquia
  • Diana María Isaza señora
  • Clara Lina Salazar señora
  • José Luis Ramírez señor
  • Ruth Emilia Ramírez señora
  • Gloria Edilma Upegui señora
  • Marta Ospina señora

DOI:

https://doi.org/10.17533/udea.rfnsp.702

Keywords:

Dengue, pregnancy, infant, newborn, congenital malformation, disease transmission, vertical

Abstract

Objective: a cohort study of 39 pregnant women with dengue fever and 39 without the disease was performed in Antioquia, Colombia, from January 2000 to December 2002 in order to determine the adverse effects of dengue fever on pregnancy and on the newborn child. Results: in the group with dengue, 7 cases with vaginal hemorrhage (17.9%) (P=0.005) and 2 spontaneous abortions (5.1%) were observed. One death was caused by dengue and in 20.5% of cases labor was concomitant with infection. Eight newborns presented acute fetal distress (21.6%) (P=0.0026), and 11 presented Apgar scores lower than 7 (29.7%) (P=0.0002). Conclusion: women infected with dengue virus during gestation have risk of vaginal hemorrhage and frequently present an increase in uterus activity; furthermore, dengue infection in pregnancy may predispose for acute fetal distress.
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Author Biography

Berta Nelly Restrepo, Universidad de Antioquia

Profesor Facultad Nacional de Salud Pública

References

(1). Gubler DJ. Dengue and dengue hemorrhagicfever. Clin Mic Rev. 1998;11:480-496. DOI: https://doi.org/10.1128/CMR.11.3.480

(2). SIVIGILA. Sistema de Vigilancia en Salud Pública. Instituto Nacional de Salud. Ministeriode Salud de Colombia 2002; 52:3-4.

(3). SIVIGILA. Sistema de Vigilancia en Salud Pú-blica. Instituto Nacional de Salud. Ministeriode Salud. Enero 06 a 12 2002:2

(4). Sierra ML, Vélez LM, Castañeda AM, Galea-no LA, Molina AL, Tabares Z et al. Análisis dela morbimortalidad. Diagnóstico de la situaciónde salud en Antioquia. Rev Epidemiol Antio-quia. 2000; 25:83-205.

(5). Carles G, Peiffer H, Talarmin A. Effects of den-gue fever during pregnancy in French Guiana.Clin Infect Dis 1999;28:637-640. DOI: https://doi.org/10.1086/515144

(6). Carles G, Talarmin A, Peneau Ch, Bertsch M.Dengue fever and pregnancy. A study of 38 ca-ses in French Guiana. J Gynecol Obstet BiolReprod 2000;29:758-762 .

(7). Thaithumyanon P, Thisyakorn U, Deeroj-nawong J, Innis BL. Dengue infection 5com-plicated by several hemorrhage and verticaltransmission in a parturient woman. Clin InfecDis 1994;18:248-249. DOI: https://doi.org/10.1093/clinids/18.2.248

(8). Poli L, Chungue E, Soulignac O, Gestas P, KuoP, Papouin-Rauzy M. Materno-fetal dengue.Apropos o 5 cases observed during the epide-mics in Tahiti (1989). Bull Soc Pathol Exot1991;84:513-521.

(9). Chye JK, Lim CT, Ng KB, Lim JM, George R,Lam SK. Vertical transmission of dengue. ClinInfec Dis 1997;25:1374-1377. DOI: https://doi.org/10.1086/516126

(10). Bunyavejchevin S, Tanawattanacharoen S, Tae-chakraichana N, Thisyakorn U, TannirandornT, Limpaphayom K. Dengue hemorrhagic fe-ver during pregnancy: antepartum, intrapartumand postpartum management. J Obstet Gynae-col Res 1997;23:445-448. DOI: https://doi.org/10.1111/j.1447-0756.1997.tb00871.x

(11). Restrepo BN, Isaza DM, Salazar CL, UpeguiGE, Ospina M, Ramírez JL et al. Efectos delvirus del dengue durante el embarazo. Mede-llín. Colombia. Infectio 2002;6:197-203.

(12). Restrepo BN, Isaza DM, Salazar CL, RamírezJL, Upegui GE, Ospina M, et al. Efectos de lainfección por el virus del dengue durante el em-barazo, sobre el feto y el recién nacido. Mede-llín. Colombia. Biomédica 2003;23:416-419. DOI: https://doi.org/10.7705/biomedica.v23i4.1236

(13). Chong KY, Lin KC. A preliminary report of thefetal effects of dengue infection in pregnancy.Gaoxiong Yi Xue Ke Xue Za Zhi 1989; 5:31-34.

(14). Sharma JB, Gulati N. Potential relationship bet-ween dengue fever and neural tube defects in anorthern district of India. Int J Gynecol Obstet1992;39:291-295. DOI: https://doi.org/10.1016/0020-7292(92)90260-P

(15). Boussemart T, Babe P, Sibille G, Neyret C, Ber-chel C. Prenatal transmission of dengue : twonew cases. J Perinatol 2001; 21:255-257. DOI: https://doi.org/10.1038/sj.jp.7200530

(16). Figueiredo LT, Carlucci RH, Duarte G. Estudoprospectivo com lactantes cujas maes tiveramdengue durante a gravidez. Rev Inst Med TropSao Paulo 1994; 36:417-421. DOI: https://doi.org/10.1590/S0036-46651994000500005

(17). Cantelar N, Molina LA. Dengue. Estudio clí-nico serológico en madres y recién nacidos. Tra-bajo preliminar. Rev Cubana Med Trop 1981;33:96-105.

(18). Fernández R, Rodríguez T, Borbonet F, Váz-quez S, Guzmán MG, Kouri G. Estudio de larelación dengue-embarazo en un grupo de ma-dres cubanas. Rev Cubana Med Trop 1994;46:76-78.

(19). Organización Panamericana de la Salud. Den-gue y dengue hemorrágico en las Américas:guías para su prevención y control. Washing-ton: OPS / OMS; 1995. (Publicación Científi-ca y Técnica, 548).

(20). Gubler DJ, Kuno G, Sather GE, Vélez M, Oli-ver A. Use of mosquito cell cultures and speci-fic monoclonal antibodies for routine survei-llance of dengue viruses. Am J Trop Med Hyg1984;33:158-165. DOI: https://doi.org/10.4269/ajtmh.1984.33.158

(21). Guzmán MG, Kouri G. Advances in denguediagnosis. Clin Diagn Lab Inmunol 1996;3:621-627. DOI: https://doi.org/10.1128/cdli.3.6.621-627.1996

(22). Lanciotti RS, Calisher CH, Gubler DJ, ChangGJ, Vomdam AV. Rapid detection and typingof dengue viruses from clinical samples byusing reverse transcriptase-polymerase chainreaction. J Clin Microbiol 1992;30:545-551. DOI: https://doi.org/10.1128/jcm.30.3.545-551.1992

(23). Fisher AM, Cockwell AE, Moore KJ, GregsonNM, Campell PL, Campell CM et al. Rapid insitu harvesting and cytogenetic analysis of pe-rinatal tissues samples. Prenat Diagn 1996;16:615-621. DOI: https://doi.org/10.1002/(SICI)1097-0223(199607)16:7<615::AID-PD920>3.0.CO;2-9

(24). Seabringht MA. Rapid banding technique forhuman chromosomes. Lancet 1971;2:971-972. DOI: https://doi.org/10.1016/S0140-6736(71)90287-X

(25). Dean AG, Dean JA, Coulombier D, Brendel K,Smith DC, Burton AH, Dicker RC, Sulivan K,Fagan RF, Arner TG. Epi Info Version 6: a Wordprocessing, database, and statistics program forepidemiology on microcomputers. Atlanta,Georgia: Centers for Disease Control and Pre-vention; 1994.

(26). Mims C, PlayFair J, Roitt I, Wakelin D, Willia-ms R. Medical microbiology. 2a ed. London:Mosby;1998.

(27). Bravo JR, Guzmán MG, Kouri G. Why denguehaemorrhagic fever in Cuba?1. Individual riskfactors for dengue haemorrhage fever/dengueshock syndrome (FHD/DSS). Trans R Soc TropMed Hyg 1987;81:816-820. DOI: https://doi.org/10.1016/0035-9203(87)90041-1

Published

2009-02-09

How to Cite

1.
Restrepo BN, Isaza DM, Salazar CL, Ramírez JL, Ramírez RE, Upegui GE, Ospina M. Dengue y embarazo en Antioquia, Colombia. Rev. Fac. Nac. Salud Pública [Internet]. 2009 Feb. 9 [cited 2025 Apr. 3];22(1). Available from: https://revistas.udea.edu.co/index.php/fnsp/article/view/702

Issue

Section

Research