Epilepsia y actividad física: conceptos desde la perspectiva de las ciencias básicas
DOI:
https://doi.org/10.17533/udea.iatreia.v30n3a04Palabras clave:
deporte, epilepsia, ejercicio, investigación básicaResumen
La Organización Mundial de la Salud considera que la epilepsia es una prioridad de salud pública. A las personas afectadas se les restringe con frecuencia su participación en actividades físicas y deportivas, pero los estudios clínicos han demostrado un efecto benéfico de la actividad física sobre el control de las crisis epilépticas. Se describen los hallazgos desde la perspectiva de las ciencias básicas que demuestran los mecanismos reguladores del efecto del ejercicio sobre la epileptogénesis, el control de la enfermedad y de su comorbilidad psiquiátrica. Tanto las investigaciones clínicas como las básicas indican que se debería considerar la actividad física como una estrategia terapéutica complementaria en las personas con epilepsia, la cual está disponible en todas partes del mundo y a un muy bajo costo.
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(1.) Levira F, Thurman DJ, Sander JW, Hauser WA, Hesdorffer DC, Masanja H, et al. Premature mortality of epilepsy in low-and middle-income countries: A systematic review from the Mortality Task Force of the International League Against Epilepsy. Epilepsia. 2017 Jan;58(1):6-16. DOI 10.1111/epi.13603.
(2.) Pan American Health Organization [Internet]. Washington: PAHO; 2015 [cited 2016 Jan 18]. World Health Assembly passed a resolution on strengthe- ning care for epilepsy. Available from: http://www.paho.org/bulletins/index.php?option=com_content&view=article&id=1853%3Aworld-health-assem- bly-passed-a-resolution-on-strengthening-care-for- epilepsy&catid=931%3Amay-june-2015&lang=es
(3.) Covanis A, Guekht A, Li S, Secco M, Shakir R, Perucca E. From global campaign to global commitment: The World Health Assembly’s Resolution on epilepsy. Epilepsia. 2015 Nov;56(11):1651-7. DOI 10.1111/epi.13192.
(4.) Li S. Commentary: From global campaign to global commitment. Epilepsia. 2015 Nov;56(11):1658-9. DOI 10.1111/epi.13208.
(5.) Shallcross AJ, Becker DA, Singh A, Friedman D, Montesdeoca J, French J, et al. Illness perceptions mediate the relationship between depression and quality of life in patients with epilepsy. Epilepsia. 2015 Nov;56(11):e186-90. DOI 10.1111/epi.13194.
(6.) Puka K, Smith ML. Predictors of long-term quality of life after pediatric epilepsy surgery. Epilepsia. 2015 Jun;56(6):873-81. DOI 10.1111/epi.13004.
(7.) Jacoby A, Sudell M, Tudur Smith C, Crossley J, Marson AG, Baker GA, et al. Quality-of-life outcomes of initiating treatment with standard and newer antiepileptic drugs in adults with new-onset epilepsy: findings from the SANAD trial. Epilepsia. 2015 Mar;56(3):460- 72. DOI 10.1111/epi.12913.
(8.) Reilly C, Taft C, Nelander M, Malmgren K, Olsson I. Health-related quality of life and emotional well-being in parents of children with epilepsy referred for presurgical evaluation in Sweden. Epilepsy Behav. 2015 Dec;53:10-4. DOI 10.1016/j.yebeh.2015.09.025.
(9.) Zamani G, Shiva S, Mohammadi M, Mahmoudi Gharaie J, Rezaei N. A survey of quality of life in adolescents with epilepsy in Iran. Epilepsy Behav. 2014 Apr;33:69-72. DOI 10.1016/j.yebeh.2014.02.012.
(10.) Hinnell C, Williams J, Metcalfe A, Patten SB, Parker R, Wiebe S, et al. Health status and health-related behaviors in epilepsy compared to other chronic conditions--a national population-based study. Epilepsia. 2010 May;51(5):853-61. DOI 10.1111/j.1528- 1167.2009.02477.x.
(11.) Turky A, Felce D, Jones G, Kerr M. A prospective case control study of psychiatric disorders in adults with epilepsy and intellectual disability. Epilepsia. 2011 Jul;52(7):1223-30. DOI 10.1111/j.1528- 1167.2011.03044.x.
(12.) Rai D, Kerr MP, McManus S, Jordanova V, Lewis G, Brugha TS. Epilepsy and psychiatric comorbidity: a nationally representative population-based study. Epilepsia. 2012 Jun;53(6):1095-103. DOI 10.1111/j.1528-1167.2012.03500.x.
(13.) Baldin E, Hesdorffer DC, Caplan R, Berg AT. Psychiatric disorders and suicidal behavior in neurotypical young adults with childhood-onset epilepsy. Epilepsia. 2015 Oct;56(10):1623-8. DOI 10.1111/epi.13123.
(14.) McLin WM, de Boer HM. Public perceptions about epilepsy. Epilepsia. 1995 Oct;36(10):957-9.
(15.) Nakken KO, Løyning A, Løyning T, Gløersen G, Larsson PG. Does physical exercise influence the occurrence of epileptiform EEG discharges in children? Epilepsia. 1997 Mar;38(3):279-84. Erratum in: Epilepsia 1997 Aug;38(8):956.
(16.) Vancini RL, de Lira CA, Scorza FA, de Albuquerque M, Sousa BS, de Lima C, et al. Cardiorespiratory and electroencephalographic responses to exhaustive acute physical exercise in people with temporal lobe epilepsy. Epilepsy Behav. 2010 Nov;19(3):504-8. DOI 10.1016/j.yebeh.2010.09.007.
(17.) de Lima C, Vancini RL, Arida RM, Guilhoto LM, de Mello MT, Barreto AT, et al. Physiological and electroencephalographic responses to acute exhaustive physical exercise in people with juvenile myoclonic epilepsy. Epilepsy Behav. 2011 Dec;22(4):718-22. DOI 10.1016/j.yebeh.2011.08.033.
(18.) Götze W, Kubicki S, Munter M, Teichmann J. Effect of physical exercise on seizure threshold (investigated by electroencephalographic telemetry). Dis Nerv Syst. 1967 Oct;28(10):664-7.
(19.) Horyd W, Gryziak J, Niedzielska K, Zieliński JJ. [Effect of physical exertion on seizure discharges in the EEG of epilepsy patients]. Neurol Neurochir Pol. 1981 Sep-Dec;15(5-6):545-52. Polish.
(20.) Arida RM, Cavalheiro EA, Scorza FA. From depressive symptoms to depression in people with epilepsy: contribution of physical exercise to improve this picture. Epilepsy Res. 2012 Mar;99(1-2):1-13. DOI 10.1016/j.eplepsyres.2011.10.012.
(21.) Eom S, Lee MK, Park JH, Jeon JY, Kang HC, Lee JS, et al. The impact of an exercise therapy on psychosocial health of children with benign epilepsy: a pilot study. Epilepsy Behav. 2014 Aug;37:151-6. DOI 10.1016/j.ye-beh.2014.06.017.
(22.) Arida RM. Impact of physical exercise therapy on behavioral and psychosocial aspects of epilepsy. Epilepsy Behav. 2014 Nov;40:90-1. DOI 10.1016/j.ye-beh.2014.08.031.
(23.) Vancini RL, de Lira CA, Arida RM. Physical exercise: potential candidate as coping strategy for people with epilepsy. Epilepsy Behav. 2013 Jul;28(1):133. DOI 10.1016/j.yebeh.2013.04.004.
(24.) Arida RM, Scorza FA, Gomes da Silva S, Schachter SC, Cavalheiro EA. The potential role of physical exercise in the treatment of epilepsy. Epilepsy Behav. 2010 Apr;17(4):432-5. DOI 10.1016/j.yebeh.2010.01.013.
(25.) Arida RM, Scorza FA, Terra VC, Scorza CA, de Almeida AC, Cavalheiro EA. Physical exercise in epilepsy: what kind of stressor is it? Epilepsy Behav. 2009 Nov;16(3):381-7. DOI 10.1016/j.yebeh.2009.08.023.
(26.) Nyberg J, Aberg MA, Torén K, Nilsson M, Ben-Menachem E, Kuhn HG. Cardiovascular fitness and later risk of epilepsy: a Swedish population-based cohort study. Neurology. 2013 Sep;81(12):1051-7. DOI 10.1212/WNL.0b013e3182a4a4c0.
(27.) Arida RM, de Jesus Vieira A, Cavalheiro EA. Effect of physical exercise on kindling development. Epilepsy Res. 1998 Apr;30(2):127-32.
(28.) Racine RJ. Modification of seizure activity by electri- cal stimulation. II. Motor seizure. Electroencephalogr Clin Neurophysiol. 1972 Mar;32(3):281-94.
(29.) Westerberg V, Lewis J, Corcoran ME. Depletion of no- radrenaline fails to affect kindled seizures. Exp Neurol. 1984 Apr;84(1):237-40.
(30.) Bortolotto ZA, Cavalheiro EA. Effect of DSP4 on hippocampal kindling in rats. Pharmacol Biochem Behav. 1986 Mar;24(3):777-9.
(31.) Besson JM, Guilbaud G, Abdelmoumene M, Chaouch A. [Physiology of nociception]. J Physiol (Paris). 1982;78(1):7-107. French.
(32.) Yoneda Y, Kanmori K, Ida S, Kuriyama K. Stress-induced alterations in metabolism of gamma-aminobutyric acid in rat brain. J Neurochem. 1983 Feb;40(2):350-6.
(33.) Souza MA, Schneider Oliveira M, Furian AF, Rambo LM, Ribeiro LR, Lima FD, et al. Swimming taining prevents pentylenetetrazol-induced inhibition of Na, K ATP-ase activity, seizures, and oxidative stress. Epilepsia. 2009;50(4):811-23. DOI 10.1111/j.1528-1167.2008.01908.x.
(34.) Packer L, Cadenas E. Oxidants and antioxidants revisited. New concepts of oxidative stress. Free Radic Res. 2007 Sep;41(9):951-2.
(35.) Navarro A, Gomez C, López-Cepero JM, Boveris A. Beneficial effects of moderate exercise on mice aging: survival, behavior, oxidative stress, and mitochondrial electron transfer. Am J Physiol Regul Integr Comp Physiol. 2004 Mar;286(3):R505-11.
(36.) Radak Z, Chung HY, Goto S. Systemic adaptation to oxidative challenge induced by regular exercise. Free Radic Biol Med. 2008 Jan;44(2):153-9. DOI 10.1016/j.freeradbiomed.2007.01.029.
(37.) Leeuwenburgh C, Heinecke JW. Oxidative stress and antioxidants in exercise. Curr Med Chem. 2001 Jun;8(7):829-38.
(38.) Salo DC, Donovan CM, Davies KJ. HSP70 and other possible heat shock or oxidative stress proteins are induced in skeletal muscle, heart, and liver during exercise. Free Radic Biol Med. 1991;11(3):239-46.
(39.) Patel AB, de Graaf RA, Mason GF, Kanamatsu T, Roth- man DL, Shulman RG, et al. Glutamatergic neuro-transmission and neuronal glucose oxidation are coupled during intense neuronal activation. J Cereb Blood Flow Metab. 2004 Sep;24(9):972-85.
(40.) Viguie CA, Frei B, Shigenaga MK, Ames BN, Packer L, Brooks GA. Antioxidant status and indexes of oxidative stress during consecutive days of exercise. J Appl Physiol (1985). 1993 Aug;75(2):566-72.
(41.) Setkowicz Z, Mazur A. Physical training decreases susceptibility to subsequent pilocarpine-induced seizures in the rat. Epilepsy Res. 2006 Oct;71(2-3):142-8.
(42.) Black JE, Isaacs KR, Anderson BJ, Alcantara AA, Greenough WT. Learning causes synaptogenesis, whereas motor activity causes angiogenesis, in cerebellar cortex of adult rats. Proc Natl Acad Sci U S A. 1990 Jul;87(14):5568-72.
(43.) Ding YH, Ding Y, Li J, Bessert DA, Rafols JA. Exercise pre-conditioning strengthens brain microvascular integrity in a rat stroke model. Neurol Res. 2006 Mar;28(2):184-9.
(44.) Isaacs KR, Anderson BJ, Alcantara AA, Black JE, Greenough WT. Exercise and the brain: angiogenesis in the adult rat cerebellum after vigorous physical activity and motor skill learning. J Cereb Blood Flow Metab. 1992 Jan;12(1):110-9. Erratum in: J Cereb Blood Flow Metab 1992 May;12(3):533.
(45.) Kleim JA, Cooper NR, VandenBerg PM. Exercise induces angiogenesis but does not alter movement representations within rat motor cortex. Brain Res. 2002 Apr;934(1):1-6.
(46.) Maruyama N, Fukuma A, Ihara I, Ando S, Moritake K. Epilepsy and variation in the frontal lobe artery. Epilepsy Res. 2005 Mar-Apr;64(1-2):71-5.
(47.) Swain RA, Harris AB, Wiener EC, Dutka MV, Morris HD, Theien BE, et al. Prolonged exercise induces angiogenesis and increases cerebral blood volume in primary motor cortex of the rat. Neuroscience. 2003;117(4):1037-46.
(48.) Cotman CW, Berchtold NC. Exercise: a behavioral intervention to enhance brain health and plasticity. Trends Neurosci. 2002 Jun;25(6):295-301.
(49.) Gómez-Pinilla F, So V, Kesslak JP. Spatial learning and physical activity contribute to the induction of fibroblast growth factor: neural substrates for increased cognition associated with exercise. Neuroscience. 1998 Jul;85(1):53-61.
(50.) Lähteinen S, Pitkänen A, Knuuttila J, Törönen P, Castrén E. Brain-derived neurotrophic factor signaling modifies hippocampal gene expression during epi-eptogenesis in transgenic mice. Eur J Neurosci. 2004 Jun;19(12):3245-54.
(51.) Levenson CW, Moore JB. Response of rat adrenal neuropeptide Y and tyrosine hydroxylase mRNA to acute stress is enhanced by long-term voluntary exercise. Neurosci Lett. 1998 Feb;242(3):177-9.
(52.) Vezzani A, Ravizza T, Moneta D, Conti M, Borroni A, Rizzi M, et al. Brain-derived neurotrophic factor immunoreactivity in the limbic system of rats after acute seizures and during spontaneous convulsions: temporal evolution of changes as compared to neuropeptide Y. Neuroscience. 1999;90(4):1445-61.
(53.) Cheng B, Mattson MP. NGF and bFGF protect rat hippocampal and human cortical neurons against hypoglycemic damage by stabilizing calcium homeostasis. Neuron. 1991 Dec;7(6):1031-41.
(54.) Nisticò G, Ciriolo MR, Fiskin K, Iannone M, De Martino A, Rotilio G. NGF restores decrease in catalase activity and increases superoxide dismutase and glutathione peroxidase activity in the brain of aged rats. Free Radic Biol Med. 1992;12(3):177-81.
(55.) Scott SA, Crutcher KA. Nerve growth factor and Alzheimer’s disease. Rev Neurosci. 1994 Jul- Sep;5(3):179-211.
(56.) Carro E, Trejo JL, Busiguina S, Torres-Aleman I. Circulating insulin-like growth factor I mediates the protective effects of physical exercise against brain insults of different etiology and anatomy. J Neurosci. 2001 Aug;21(15):5678-84.
(57.) Torres-Aleman I. Serum growth factors and neuro- protective surveillance: focus on IGF-1. Mol Neurobiol. 2000 Jun;21(3):153-60.
(58.) Denio LS, Drake ME Jr, Pakalnis A. The effect of exercise on seizure frequency. J Med. 1989;20(2):171-6.
(59.) Eriksen HR, Ellertsen B, Grønningsaeter H, Nakken KO, Løyning Y, Ursin H. Physical exercise in women with intractable epilepsy. Epilepsia. 1994 Nov-Dec;35(6):1256-64.
(60.) Götze W, Kubicki S, Munter M, Teichmann J. Effect of physical exercise on seizure threshold (investigated by electroencephalographic telemetry). Dis Nerv Syst. 1967 Oct;28(10):664-7.
(61.) Livingston S, Berman W. Participation of epileptic patients in sports. JAMA. 1973 Apr;224(2):236-8.
(62.) Nakken KO, Bjørholt PG, Johannessen SI, Løyning T, Lind E. Effect of physical training on aerobic capacity, seizure occurrence, and serum level of anti epileptic drugs in adults with epilepsy. Epilepsia. 1990 Jan-Feb;31(1):88-94.
(63.) Hellier JL, Dudek FE. Spontaneous motor seizures of rats with kainate-induced epilepsy: effect of time of day and activity state. Epilepsy Res. 1999 May;35(1):47-57.
(64.) Kuijer A. Epilepsy and exercise, electroencephalographic and biochemical studies. In: Wada JA, Penry JK editors. Advances in Epileptology: The 10th Epilepsy International Symposium. New York: Raven; 1978. p. 543.
(65.) Peixinho-Pena LF, Fernandes J, de Almeida AA, Novaes Gomes FG, Cassilhas R, Venancio DP, et al. A strength exercise program in rats with epilepsy is protective against seizures. Epilepsy Behav. 2012 Nov;25(3):323-8. DOI 10.1016/j.yebeh.2012.08.011.
(66.) Contet C, Gavériaux-Ruff C, Matifas A, Caradec C, Champy MF, Kieffer BL. Dissociation of analgesic and hormonal responses to forced swim stress using opioid receptor knockout mice. Neuropsychopharmacology. 2006 Aug;31(8):1733-44.
(67.) Hammers A, Asselin MC, Hinz R, Kitchen I, Brooks DJ, Duncan JS, et al. Upregulation of opioid receptor binding following spontaneous epileptic seizures. Brain. 2007 Apr;130(Pt 4):1009-16.
(68.) Arida RM, Scorza FA, Toscano-Silva M, Cavalheiro EA. Does exercise correct dysregulation of neuros- teroid levels induced by epilepsy? Ann Neurol. 2010 Dec;68(6):971-2. DOI 10.1002/ana.22086.
(69.) Lawrence C, Martin BS, Sun C, Williamson J, Kapur J. Endogenous neurosteroid synthesis modulates seizu- re frequency. Ann Neurol. 2010 May;67(5):689-93. DOI 10.1002/ana.21989.
(70.) Mevissen M, Ebert U. Anticonvulsant effects of mela- tonin in amygdala-kindled rats. Neurosci Lett. 1998 Nov;257(1):13-6.
(71.) Theron JJ, Oosthuizen JM, Rautenbach MM. Effect of physical exercise on plasma melatonin levels in normal volunteers. S Afr Med J. 1984 Dec;66(22):838-41.
(72.) Arida RM, Scorza CA, Scorza FA, Gomes da Silva S, da Graça Naffah-Mazzacoratti M, Cavalheiro EA. Effects of different types of physical exercise on the staining of parvalbumin-positive neurons in the hippocampal formation of rats with epilepsy. Prog Neurop- sychopharmacol Biol Psychiatry. 2007 May;31(4):814-22.
(73.) Sloviter RS, Sollas AL, Barbaro NM, Laxer KD. Calcium-binding protein (calbindin-D28K) and parvalbumin immunocytochemistry in the normal and epileptic human hippocampus. J Comp Neurol. 1991 Jun;308(3):381-96.
(74.) Arida RM, Sanabria ER, da Silva AC, Faria LC, Scorza FA, Cavalheiro EA. Physical training reverts hippocampal electrophysiological changes in rats submitted to the pilocarpine model of epilepsy. Physiol Behav. 2004 Oct;83(1):165-71.
(75.) Mata J, Thompson RJ, Jaeggi SM, Buschkuehl M, Jonides J, Gotlib IH. Walk on the bright side: physical activity and affect in major depressive disorder. J Abnorm Psychol. 2012 May;121(2):297-308. DOI 10.1037/a0023533.
(76.) Babyak M, Blumenthal JA, Herman S, Khatri P, Do-raiswamy M, Moore K, et al. Exercise treatment for major depression: maintenance of therapeutic benefit at 10 months. Psychosom Med. 2000 Sep-Oct;62(5):633-8.
(77.) Arida RM, Cavalheiro EA, Scorza FA. From depressive symptoms to depression in people with epilepsy: contribution of physical exercise to improve this picture. Epilepsy Res. 2012 Mar;99(1-2):1-13. DOI 10.1016/j.eplepsyres.2011.10.012.
(78.) Epps SA, Kahn AB, Holmes PV, Boss-Williams KA, Weiss JM, Weinshenker D. Antidepressant and anti-convulsant effects of exercise in a rat model of epilepsy and depression comorbidity. Epilepsy Behav. 2013 Oct;29(1):47-52. DOI 10.1016/j.yebeh.2013.06.023.
(79.) Lu X, Ross B, Sanchez-Alavez M, Zorrilla EP, Bartfai T. Phenotypic analysis of GalR2 knockout mice in anxiety-and depression-related behavioral tests. Neuropeptides. 2008 Aug;42(4):387-97. DOI 10.1016/j.npep.2008.04.009.
(80.) Lerner JT, Sankar R, Mazarati AM. Galanin and epilepsy. EXS. 2010;102:183-94.
(81.) Lu X, Sharkey L, Bartfai T. The brain galanin receptors: targets for novel antidepressant drugs. CNS Neurol Disord Drug Targets. 2007 Jun;6(3):183-92.
(82.) Mazarati AM, Hohmann JG, Bacon A, Liu H, Sankar R, Steiner RA, et al. Modulation of hippocampal excitability and seizures by galanin. J Neurosci. 2000 Aug;20(16):6276-81.
(83.) Reiss JI, Dishman RK, Boyd HE, Robinson JK, Holmes PV. Chronic activity wheel running reduces the severity of kainic acid-induced seizures in the rat: possible role of galanin. Brain Res. 2009 Apr;1266:54-63. DOI 10.1016/j.brainres.2009.02.030.
(84.) Nakken KO. Physical exercise in outpatients with epilepsy. Epilepsia. 1999 May;40(5):643-51.
(85.) Ogunyemi AO, Gomez MR, Klass DW. Seizures induced by exercise. Neurology. 1988 Apr;38(4):633-4.
(86.) Korczyn AD. Participation of epileptic patients in sports. J Sports Med Phys Fitness. 1979 Jun;19(2):195-8.
(87.) Schmitt B, Thun-Hohenstein L, Vontobel H, Boltshauser E. Seizures induced by physical exercise: report of two cases. Neuropediatrics. 1994 Feb;25(1):51-3.
(88.) Simpson RK Jr, Grossman RG. Seizures after jogging. N Engl J Med. 1989 Sep;321(12):835.
(89.) Werz MA. Idiopathic generalized tonic-clonic seizures limited to exercise in a young adult. Epilepsy Behav. 2005 Feb;6(1):98-101.
(90.) Sturm JW, Fedi M, Berkovic SF, Reutens DC. Exercise-induced temporal lobe epilepsy. Neurology. 2002 Oct;59(8):1246-8.
(91.) Arida RM, Cavalheiro EA, da Silva AC, Scorza FA. Physical activity and epilepsy: proven and predicted benefits. Sports Med. 2008;38(7):607-15.
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