Clinical significance of mixed anti-nuclear and anti-cytoplasmic antibody pattern
DOI:
https://doi.org/10.17533/udea.iatreia.3378Keywords:
Antibodies, Anticytoplasmic, AutoantibodiesAbstract
To date, the clinical significance of combined antinuclear (ANA) and anti-cytoplasmic (ACA) indirect immunofluorescent staining has not been comprehensively studied. ANA + ACA staining was observed in 43 (0.6%) out of 7.121 consecutive sera during ANA screening for immunologic disorders in a referral hospital; both inpatient and outpatient population were included. Homogeneous ANA + cytoplasmic was by far the most common staining pattern among 6 different fluorescent combinations detected. Disease distribution was similar in groups of patients with ANA + ACA and in those with only ANA +. We conclude that information provided by mixed antibody pattern is similar to the one obtained with the sole presence of ANA; also that the presence of the mixed pattern does not characterize any particular subgroup of LES patiens.
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