Renal Complications and Snakebite Accidents Caused by Vipers of the Bothrops Genus: A Systematic Review
DOI:
https://doi.org/10.17533/udea.iatreia.319Keywords:
Acute Kidney Injury, Bothrops, Bothrops SnakebiteAbstract
Introduction: Renal complications following snakebites remain poorly understood due to insufficient evidence. Observational studies have limitations in determining precise frequency. In Brazil, acute kidney injury (AKI) occurs in 8-43% of envenomed patients, with 15% requiring renal replacement therapy and mortality rates ranging from 8-39%. In Colombia, the incidence remains undetermined; however, a study conducted in Medellín reported a 38.5% incidence of AKI with significant clinical impact.
Objectives: To compile existing literature regarding acute renal complications in the context of Bothrops snakebite envenomation.
Methods: A systematic review was conducted following PRISMA guidelines, implementing 12 search strategies across five databases. Thoroughness, reproducibility, and methodological quality were ensured.
Results: The frequency of acute kidney injury in patients with Bothrops snakebite envenomation ranged from 0.6% to 12.8%.
Conclusions: Envenomation severity and infection are not directly associated with an increased risk of renal complications in Bothrops snakebite accidents. Advanced age, hemorrhagic manifestations, and elevated lactate dehydrogenase levels were identified as potentially associated factors.
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(1) Organización Mundial de la Salud. Envenenamiento por mordedura de serpiente [Internet]. 2024. [Citado 2024 Mar 16]. Disponible en: https://www.who.int/es/news-room/fact-sheets/detail/snakebite-envenoming
(2) Albuquerque PLMM, Paiva JHHGL, Martins AMC, Meneses GC, da Silva GB, Buckley N, et al. Clinical assessment and pathophysiology of Bothrops venom-related acute kidney injury: a scoping review. J Venom Anim Toxins Trop Dis [Internet]. 2020;26:e20190076. https://doi.org/10.1590/1678-9199-jvatitd-2019-0076
(3) Rodrigues-Sgrignolli L, Florido-Mendes GE, Carlos CP, Burdmann EA. Acute Kidney Injury Caused by Bothrops Snake Venom. Nephron Clin Pract [Internet]. 2011;119(2):c131-7. https://doi.org/10.1159/000324228
(4) Aye KP, Thanachartwet V, Soe C, Desakorn V, Thwin KT, Chamnanchanunt S, et al. Clinical and laboratory parameters associated with acute kidney injury in patients with snakebite envenomation: a prospective observational study from Myanmar. BMC Nephrol [Internet]. 2017;18(1):92. https://doi.org/10.1186/s12882-017-0510-0
(5) Albuquerque PLMM, Silva GB, Jacinto CN, Lima JB, Lima CB, Amaral YS, et al. Acute kidney injury after snakebite accident treated in a Brazilian tertiary care centre. Nephrol Carlton Vic [Internet]. 2014;19(12):764-70. https://doi.org/10.1111/nep.12327
(6) Li W, Chen F, Wu S. The Related Risk Factors Analysis of Snake-Bite Induced Acute Kidney Injury. Med Sci Monit [Internet]. 2016;22:2335-9. https://doi.org/10.12659/MSM.899072
(7) Kanjanabuch T, Sitprija V. Snakebite Nephrotoxicity in Asia. Semin Nephrol [Internet]. 2008;28(4):363-72. https://doi.org/10.1016/j.semnephrol.2008.04.005
(8) Campos-Alves E, Sachett JAG, Souza-Sampaio V, de-Brito-Sousa JD, Silva de Oliveira S, Nascimento EF, et al. Predicting acute renal failure in Bothrops snakebite patients in a tertiary reference center, Western Brazilian Amazon. PloS One [Internet]. 2018;13(8):e0202361. https://doi.org/10.1371/journal.pone.0202361
(9) Sasa M, Segura-Cano SE. New insights into snakebite epidemiology in Costa Rica: A retrospective evaluation of medical records. Toxicon X [Internet]. 2020;7:100055. https://doi.org/10.1016/j.toxcx.2020.100055
(10) Otero R, Gutiérrez J, Mesa MB, Duque E, Rodríguez O, Arango JL, et al. Complications of Bothrops, Porthidium, and Bothriechis snakebites in Colombia. A clinical and epidemiological study of 39 cases attended in a university hospital. Toxicon [Internet]. 2002;40(8):1107-14. https://doi.org/10.1016/S0041-0101(02)00104-6
(11) Pinho FMO, Burdmann EdeA. Insuficiência renal aguda após envenenamento crotálico: prevalência e fatores de risco - um estudo prospectivo [Tesis]. São Paulo; Universidad de São Paulo. 2004. Disponible en: http://www.teses.usp.br/teses/disponiveis/5/5148/tde-10042007-141228/
(12) Ribeiro LA, Gadia R, Jorge MT. Comparison between the epidemiology of accidents and the clinical features of envenoming by snakes of the genus Bothrops, among elderly and non-elderly adults. Rev Soc Bras Med Trop [Internet]. 2008;41(1):46-9. https://doi.org/10.1590/S0037-86822008000100009
(13) Nishioka SDA, Silveira PVP. A Clinical and Epidemiologic Study of 292 Cases of Lance-Headed Viper Bite in a Brazilian Teaching Hospital. Am J Trop Med Hyg [Internet]. 1992;47(6):805-10. https://doi.org/10.4269/ajtmh.1992.47.805
(14) Moher D, Shamseer L, Clarke M, Ghersi D, Liberati A, Petticrew M, et al. Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015 statement. Syst Rev [Internet]. 2015;4(1):1. https://doi.org/10.1186/2046-4053-4-1
(15) Castaño-Hernandez I, Berbeo M. Correlation of renal complications and Bothrops snakebite accidents: systematic review [Internet]. 2023. [citado 2024 Mar 16]. Disponible en: https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=414513
(16) Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD, et al. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ [Internet]. 2021;372:n71. Available from: https://pubmed.ncbi.nlm.nih.gov/33782057/
(17) Rayyan. Intelligent Systematic Review - Rayyan [Internet]. 2021 [citado 2024 Mar 16]. Available from: https://www.rayyan.ai/
(18) JBI. Critical Appraisal Tools [Internet]. [citado 2024 Mar 16]. Available from: https://jbi.global/critical-appraisal-tools
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