Pharmacogenitecs: importance of acetylating phenotype determination
DOI:
https://doi.org/10.17533/udea.iatreia.3548Keywords:
Pharmacogenetics, Acetylator phenotype, PolymorphismAbstract
Research concerning hereditary basis of response to drugs is known as pharmacogenetics; at least 60 pharmacogenetic polymorphisms have been described in clinical medicine; many of them are responsible for marked differences in predisposition towards drug toxicity or cancer. The debrisoquine.esparteine and the N-acetylation polymorphisms are presently the most important, since they involve both many frequently prescribed drugs, and carcinogenic amines that use this enzyme for inactivation.
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