Interleukin 1-beta (Il-1β) polymorphism and orthodontics: a systematic review


  • Juan Fernando Aristizábal Universidad del Valle
  • Héctor Ríos Universidad de Michigan
  • Diego Rey Universidad CES
  • María Antonia Álvarez Universidad CES
  • Beatriz Parra-Patiño Universidad del Valle
  • Mario Ortiz Universidad del Valle



Interleukin-1 beta, Tooths movement techniques, Orthodontics, Root resorption


Introduction: the aim of this systematic review is to explore the published literature to analyze the relationship between polymorphism of interleukin 1-beta (IL-1β) and orthodontics. Methods: the search strategy developed for Medline, Scopus and Embase was used, verifying search records and selecting articles according to the guidelines set forth by Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). Two researchers evaluated studies in humans undergoing orthodontic treatment that evaluate IL-1β polymorphism, movement speed and/or root resorption, including clinical trials, case-control studies, cross-sectional studies, and cohort studies, published up to April 2017. Results: of the 123 relevant articles identified, 9 studies published between 2001 and 2016 were included in the detailed analysis. Studies on tooth movement generally agree that there is an increase in IL-1β levels in the first hours after starting the orthodontic treatment. Conclusion: an association of IL-1β polymorphism with external root resorption and tooth movement speed was found.

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Author Biographies

Juan Fernando Aristizábal, Universidad del Valle

DDs, MSc, Professor and Head, Department of Orthodontics, Universidad del Valle, Cali


Héctor Ríos, Universidad de Michigan

DDs, PhD, Professor, Department of Periodontics and Oral Medicine, University of Michigan

Diego Rey, Universidad CES

DDs, Professor and Head, Department of Orthodontics, Universidad CES, Medellín. Colombia

María Antonia Álvarez, Universidad CES

DDs, Professor, Department of Orthodontics, Universidad CES, Medellín. Colombia

Beatriz Parra-Patiño, Universidad del Valle

MSc, PhD, Professor Department of Microbiology, Universidad del Valle, Cali. Colombia

Mario Ortiz, Universidad del Valle

DDs, MSc, Professor Department of Orthodontics, Universidad del Valle, Cali. Colombia


Iwasaki LR, Crouch LD, Nickel JC. Genetic factors and tooth movement. Semin Orthod. 2008; 14(2): 135–45. DOI:

Valderrama G, Vijande F, Escribano J, Garrido-Pertierra A, Bascones A. El polimorfismo de la IL-1 y su eventual asociación con la enfermedad periodontal crónica: una revisión de la literatura (II). Av Periodoncia. 2005; 17(3): 157–63.

Fernández R, Tobón DM, Osorno K, Zuluaga OE. Polimorfismo genético para la interleukina-1ß como modulador de los procesos de reabsorción ósea. Rev CES Odontol. 2012; 25(1): 92–101.

Iwasaki LR, Gibson CS, Crouch LD, Marx DB, Pandey JP, Nickel JC. Speed of tooth movement is related to stress and IL-1 gene polymorphisms. Am J Orthod Dentofacial Orthop. 2006; 130(6): e1–9. DOI:

Al-Qawasmi RA, Hartsfield JK, Everett ET, Flury L, Liu L, Foroud TM et al. Genetic predisposition to external apical root resorption. Am J Orthod Dentofacial Orthop. 2003; 123(3): 242–52. DOI:

Segal GR, Schiffman PH, Tuncay OC. Meta-analysis of the treatment-related factors of external apical root resorption. Orthod Craniofacial Res. 2004; 7(2): 71–8.

Richter AE, Arruda AO, Peters MC, Sohn W. Incidence of caries lesions among patients treated with comprehensive orthodontics. Am J Orthod Dentofacial Orthop. 2011; 139(5): 657–64. DOI:

Johal A, Alyaqoobi I, Patel R, Cox S. The impact of orthodontic treatment on quality of life and self-esteem in adult patients. Eur J Orthod. 2015; 37(3): 233–7. DOI:

Aristizábal JF. Ortodoncia acelerada y ortodoncia de tránsito expreso (OTE)®: un concepto contemporáneo de alta eficiencia. CES Odontol. 2014; 27(1): 56–73.

Moher D, Liberati A, Tetzlaff J, Altman DG, PRISMA Group. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. PLoS Med. 2009; 6(7): e1000097. DOI:

Masella RS, Meister M. Current concepts in the biology of orthodontic tooth movement. Am J Orthod Dentofacial Orthop. 2006; 129(4): 458–68. DOI:

Hood L, Heath JR, Phelps ME, Lin B. Systems biology and new technologies enable predictive and preventative medicine. Science. 2004; 306(5696): 640–3. DOI:

Furushima K, Shimo-Onoda K, Maeda S, Nobukuni T, Ikari K, Koga H et al. Large-scale screening for candidate genes of ossification of the posterior longitudinal ligament of the spine. J Bone Miner Res. 2002; 17(1): 128–37. DOI:

Ho NC, Jia L, Driscoll CC, Gutter EM, Francomano C a. A skeletal gene database. J Bone Miner Res. 2000; 15(11): 2095–122. DOI:

Roberts WE, Huja SS, Roberts JA. Bone modeling: biomechanics, molecular mechanisms, and clinical perspectives. Semin Orthod. 2004; 10(2): 123–61. DOI:

Bruderer M, Richards RG, Alini M, Stoddart MJ. Role and regulation of RUNX2 in osteogenesis. Eur Cells Mater. 2014; 28: 269–86.

Mackie EJ. Osteoblasts: novel roles in orchestration of skeletal architecture. Int J Biochem Cell Biol. 2003; 35(9): 1301–5.

Kang KS, Lee SJ, Lee H, Moon W, Cho DW. Effects of combined mechanical stimulation on the proliferation

and differentiation of pre-osteoblasts. Exp Mol Med. 2011; 43(6): 367–73. DOI:


Seeman E, Delmas PD. Bone quality--the material and structural basis of bone strength and fragility. N Engl J Med. 2006; 354(21): 2250–61. DOI:

Dallas SL, Prideaux M, Bonewald LF. The osteocyte: an endocrine cell… and more. Endocr Rev. 2013; 34(5): 658–90. DOI:

Matsumoto T, Iimura T, Ogura K, Moriyama K, Yamaguchi A. The role of osteocytes in bone resorption during orthodontic tooth movement. J Dent Res. 2013; 92(4): 340–5. DOI:

Shoji-Matsunaga A, Ono T, Hayashi M, Takayanagi H, Moriyama K, Nakashima T. Osteocyte regulation of orthodontic force-mediated tooth movement via RANKL expression. Sci Rep. 2017; 7(1): 1–8. DOI:

Xiong J, Brien CAO. Osteocyte RANKL: New insights into the control of bone remodeling. J Bone Miner Res. 2012; 27(3): 499–505. DOI:

Boyle WJ, Simonet WS, Lacey DL. Osteoclast differentiation and activation. Nature. 2003; 423(6937):

–42. DOI:

Teitelbaum SL. Bone resorption by osteoclasts. Science. 2000; 289(5484): 1504-8. DOI:

Alhashimi N, Frithiof L, Brudvik P, Bakhiet M. Orthodontic tooth movement and de novo synthesis of proinflammatory cytokines. Am J Orthod Dentofacial Orthop. 2001; 119(3): 307–12. DOI:

Lee DY, Ahn HW, Herr Y, Kwon YH, Kim SH, Kim EC. Periodontal responses to augmented corticotomy with collagen membrane application during orthodontic buccal tipping in dogs. Biomed Res Int. 2014; 2014. DOI:

Wilcko W, Wilcko MT. Accelerating tooth movement: the case for corticotomy-induced orthodontics. Am J Orthod Dentofacial Orthop. 2013; 144(1): 4-12. DOI:

Buschang PH, Campbell PM, Ruso S. Accelerating tooth movement with corticotomies: is it possible and desirable? Semin Orthod. 2012; 18(4): 286–94.

Gong Y, Lu J, Ding X. Clinical, microbiologic, and immunologic factors of orthodontic treatmentinduced gingival enlargement. Am J Orthod Dentofacial Orthop. 2011; 140(1): 58–64. DOI:

Nomura S, Takano-Yamamoto T. Molecular events caused by mechanical stress in bone. Matrix Biol. 2000; 19(2): 91–6.

Pavlin D, Gluhak-Heinrich J. Effect of mechanical loading on periodontal cells. Crit Rev Oral Biol Med. 2001; 12(5): 414–24.

Cork MJ, Tarlow JK, Clay FE, Crane A, Blakemore AI, McDonagh AJ et al. An allele of the interleukin-1 receptor antagonist as a genetic severity factor in alopecia areata. J Invest Dermatol. 1995;104(5 Suppl): 15S–6.

Pociot F, Mølvig J, Wogensen L, Worsaae H, Nerup J. A TaqI polymorphism in the human interleukin-1 beta (IL-1 beta) gene correlates with IL-1 beta secretion in vitro. Eur J Clin Invest. 1992; 22(6): 396–402.

Hurme M, Santtila S. IL-1 receptor antagonist (IL-1Ra) plasma levels are co-ordinately regulated by both IL-

Ra and IL-1beta genes. Eur J Immunol. 1998; 28(8): 2598–602. DOI:


Danis VA, Millington M, Hyland VJ, Grennan D. Cytokine production by normal human monocytes: intersubject variation and relationship to an IL-1 receptor antagonist (IL-1Ra) gene polymorphism. Clin Exp Immunol. 1995; 99(2): 303–10. DOI:

Krishnan V, Davidovitch Z. Cellular, molecular, and tissue-level reactions to orthodontic force. Am J Orthod

Dentofacial Orthop. 2006; 129(4): e1–32.

Davidovitch Z. Tooth movement. Crit Rev Oral Biol Med. 1991; 2(4): 411–50.

Owman-Moll P, Kurol J, Lundgren D. Continuous versus interrupted continuous orthodontic force related to early tooth movement and root resorption. Angle Orthod. 1995; 65(6): 401-2.

Owman-Moll P, Kurol J, Lundgren D. Effects of a doubled orthodontic force magnitude on tooth movement and root resorptions. An inter-individual study in adolescents. Eur J Orthod. 1996; 18(2): 141–50. DOI:

Iwasaki LR, Crouch LD, Tutor A, Gibson S, Hukmani N, Marx DB et al. Tooth movement and cytokines in gingival crevicular fluid and whole blood in growing and adult subjects. Am J Orthod Dentofacial Orthop. 2005; 128(4): 483–91. DOI:

Mavreas D, Athanasiou AE. Factors affecting the duration of orthodontic treatment: a systematic review. Eur J Orthod. 2008; 30(4): 386–95. DOI:

Fink DF, Smith RJ. The duration of orthodontic treatment. Am J Orthod Dentofacial Orthop. 1992; 102(1): 45–51. DOI:

Dolce C, Scott Malone J, Wheeler TT. Current concepts in the biology of orthodontic tooth movement.

Semin Orthod. 2002; 8(1): 6–12. DOI:

Zainal Ariffin SH, Yamamoto Z, Zainol Abidin lntan Z, Megat Abdul Wahab R, Zainal Ariffin Z. Cellular and molecular changes in orthodontic tooth movement. Sci World J. 2011; 11: 1788–803. DOI:

Dinarello C. Interleukin-1 and interleukin-1 antagonism. Blood. 1991; 77(8): 1627–52.

Stashenko P, Obernesser MS, Dewhirst FE. Effect of immune cytokines on bone. Immunol Invest. 1989; 18(1–4): 239–49.

Uematsu S, Mogi M, Deguchi T. Interleukin (IL)-1 beta, IL-6, tumor necrosis factor-alpha, epidermal growth

factor, and beta 2-microglobulin levels are elevated in gingival crevicular fluid during human orthodontic tooth movement. J Dent Res. 1996; 75(1): 562–7. DOI:

Grieve WG 3rd, Johnson GK, Moore RN, Reinhardt RA, DuBois LM. Prostaglandin E (PGE) and interleukin-1

beta (IL-1 beta) levels in gingival crevicular fluid during human orthodontic tooth movement. Am J Orthod Dentofacial Orthop. 1994; 105(4): 369–74.

Iwasaki LR, Haack JE, Nickel JC, Reinhardt RA, Petro TM. Human interleukin-1 beta and interleukin-1 receptor antagonist secretion and velocity of tooth movement. Arch Oral Biol. 2001; 46(2): 185–9. DOI:

Nieto-Nieto N, Solano JE, Yañez-Vico R. External apical root resorption concurrent with orthodontic forces: the genetic influence. Acta Odontol Scand. 2017; 75(4): 280–7. DOI:

Harris EF, Kineret SE, Tolley EA. A heritable component for external apical root resorption in patients treated orthodontically. Am J Orthod Dentofacial Orthop. 1997; 111(3): 301–9.

Hartsfield JKJ, Everett ET, Al-Qawasmi RA. Genetic factors in external apical root resorption and orthodontic treatment. Crit Rev Oral Biol Med. 2004; 15(2): 115–22.

Abass SK, Hartsfield JK, Al-Qawasmi RA, Everett ET, Foroud TM, Roberts WE. Inheritance of susceptibility to root resorption associated with orthodontic force in mice. Am J Orthod Dentofacial Orthop. 2008;134(6): 742–50. DOI:

Bastos Lages EM, Drummond AF, Pretti H, Costa FO, Lages EJP, Gontijo AI et al. Association of functional gene polymorphism IL-1 beta in patients with external apical root resorption. Am J Orthod Dentofacial Orthop. 2009; 136(4): 542–6. DOI:

Iglesias-Linares A, Yañez-Vico RM, Ortiz-Ariza E, Ballesta S, Mendoza-Mendoza A, Perea E et al. Postorthodontic external root resorption in root-filled teeth is influenced by interleukin-1b polymorphism. J Endod. 2012; 38(3): 283–7. DOI:

Tomoyasu Y, Yamaguchi T, Tajima A, Inoue I, Maki K. External apical root resorption and the interleukin-1B

gene polymorphism in the Japanese population. Orthod Waves. 2009; 68(4): 152–7. DOI:

Linhartova P, Cernochova P, Izakovicova Holla L. IL1 gene polymorphisms in relation to external apical root resorption concurrent with orthodontia. Oral Dis. 2013; 19(3): 262–70. DOI:

Lince Vides F, De La Ossa Salcedo J, Hernandez Tirado R, Buelvas Montes Y, Bustillo Arrieta J, Madera Anaya M. Polimorfismo (+3954C>T) del gen IL-1β y su asociación con la resorción radicular apical externa post-tratamiento ortodóntico. Int J Odontostomat. 2016; 10(2): 243–8. DOI:

Wu FL, Wang LY, Huang YQ, Guo WB, Liu CD, Li SG. Interleukin-1β +3954 polymorphisms and risk of external apical root resorption in orthodontic treatment: a meta-analysis. Genet Mol Res. 2013; 12(4): 4678–86. DOI:

Iwasaki L, Chandler J, Marx D, Pandey J, Nickel J. IL-1 gene polymorphisms, secretion in gingival crevicular fluid, and speed of human orthodontic tooth movement. Orthod Craniofac Res. 2009; 12(2): 129–40. DOI:

Yamaguchi M, Yoshii M, Kasai K. Relationship between substance P and interleukin-1beta in gingival crevicular fluid during orthodontic tooth movement in adults. Eur J Orthod. 2006; 28(3): 241–6. DOI:



How to Cite

Aristizábal, J. F., Ríos, H., Rey, D., Álvarez, M. A., Parra-Patiño, B., & Ortiz, M. (2019). Interleukin 1-beta (Il-1β) polymorphism and orthodontics: a systematic review. Revista Facultad De Odontología Universidad De Antioquia, 31(1-2), 147–161.

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