Interleukin 1-beta (Il-1β) polymorphism and orthodontics: a systematic review


  • Juan Fernando Aristizábal Universidad del Valle
  • Héctor Ríos Universidad de Michigan
  • Diego Rey Universidad CES
  • María Antonia Álvarez Universidad CES
  • Beatriz Parra-Patiño Universidad del Valle
  • Mario Ortiz Universidad del Valle



Interleukin-1 beta, Tooths movement techniques, Orthodontics, Root resorption


Introduction: the aim of this systematic review is to explore the published literature to analyze the relationship between polymorphism of interleukin 1-beta (IL-1β) and orthodontics. Methods: the search strategy developed for Medline, Scopus and Embase was used, verifying search records and selecting articles according to the guidelines set forth by Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). Two researchers evaluated studies in humans undergoing orthodontic treatment that evaluate IL-1β polymorphism, movement speed and/or root resorption, including clinical trials, case-control studies, cross-sectional studies, and cohort studies, published up to April 2017. Results: of the 123 relevant articles identified, 9 studies published between 2001 and 2016 were included in the detailed analysis. Studies on tooth movement generally agree that there is an increase in IL-1β levels in the first hours after starting the orthodontic treatment. Conclusion: an association of IL-1β polymorphism with external root resorption and tooth movement speed was found.

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Author Biographies

Juan Fernando Aristizábal, Universidad del Valle

DDs, MSc, Professor and Head, Department of Orthodontics, Universidad del Valle, Cali


Héctor Ríos, Universidad de Michigan

DDs, PhD, Professor, Department of Periodontics and Oral Medicine, University of Michigan

Diego Rey, Universidad CES

DDs, Professor and Head, Department of Orthodontics, Universidad CES, Medellín. Colombia

María Antonia Álvarez, Universidad CES

DDs, Professor, Department of Orthodontics, Universidad CES, Medellín. Colombia

Beatriz Parra-Patiño, Universidad del Valle

MSc, PhD, Professor Department of Microbiology, Universidad del Valle, Cali. Colombia

Mario Ortiz, Universidad del Valle

DDs, MSc, Professor Department of Orthodontics, Universidad del Valle, Cali. Colombia


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How to Cite

Aristizábal, J. F., Ríos, H., Rey, D., Álvarez, M. A., Parra-Patiño, B., & Ortiz, M. (2019). Interleukin 1-beta (Il-1β) polymorphism and orthodontics: a systematic review. Revista Facultad De Odontología Universidad De Antioquia, 31(1-2), 147–161.