Assessment of adherence to preventive treatment of plaque-induced oral diseases using sugar-free gums: a controlled clinical trial


  • María Cecilia Martínez-Pabón Universidad de Antioquia
  • Carolina Mesa-Arango Universidad de Antioquia
  • Cecilia María Martínez-Delgado Universidad de Antioquia
  • María Isabel Pérez-Cano Universidad de Antioquia
  • Diana María Isaza-Guzmán Universidad de Antioquia
  • Sergio Iván Tobón-Arroyave Universidad de Antioquia



Tooth decay, Chewing gum, Cariostatic agents, Adherence to treatment, Public health


Introduction: the aim of this study was to assess the adherence to a preventive treatment of plaque-induced oral diseases using two sugar-free gums, establishing their effect on cariogenic bacteria counts as abiological marker of treatment response. Methods: a double-blind, randomized, parallel-group, controlled intervention study was conducted in 96 young adult university students in an experimental period of 30 days. Participants were distributed into two groups and given a chewing gum with either pentitol or hexitol + CPP-ACP complex to be taken three times a day for 20 minutes after conventional oral hygiene. Saliva samples were collected at baseline to evaluate counts of Streptococcus mutans (SM) and Lactobacillus spp. A survey was conducted at the end of the experimental period to assess the levels of adherence to treatment, remeasuring bacterial counts. Results: SM counts showed statistically significant differences between the study groups at the end of the experimental period, with a decreasing tendency in both groups. Intragroup difference was observed in patients who took pentitol gum with a marked reduction in SM counts. Conclusion: the final estimate of adherence to treatment showed that the type of chewing gum patients were given had no influence and therefore such gums can be used, considering the therapeutic agents that most contribute to patient’s particular case and preferences.

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Author Biographies

María Cecilia Martínez-Pabón, Universidad de Antioquia

DDS. MSc in Microbiology. School of Dentistry, Universidad de Antioquia, Medellín, Colombia

Carolina Mesa-Arango, Universidad de Antioquia

DDS. School of Dentistry, Universidad de Antioquia, Medellín, Colombia

Cecilia María Martínez-Delgado, Universidad de Antioquia

DDS. Specialist in Epidemiology. Master in University Management. School of Dentistry, Universidad de Antioquia, Medellín, Colombia

María Isabel Pérez-Cano, Universidad de Antioquia

DDS. Specialist in Radiology. School of Dentistry, Universidad de Antioquia, Medellín, Colombia

Diana María Isaza-Guzmán, Universidad de Antioquia

Bacteriologist. MSc in Basic Biomedical Sciences. School of Dentistry, Universidad de Antioquia, Medellín, Colombia

Sergio Iván Tobón-Arroyave, Universidad de Antioquia

DDS. Stomatologist and Oral Surgeon. School of Dentistry, Universidad de Antioquia, Medellín, Colombia


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How to Cite

Martínez-Pabón, M. C., Mesa-Arango, C., Martínez-Delgado, C. M., Pérez-Cano, M. I., Isaza-Guzmán, D. M., & Tobón-Arroyave, S. I. (2019). Assessment of adherence to preventive treatment of plaque-induced oral diseases using sugar-free gums: a controlled clinical trial. Revista Facultad De Odontología Universidad De Antioquia, 31(1-2), 57–67.

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