ASSESSMENT OF ADHERENCE TO PREVENTIVE TREATMENT OF PLAQUE-INDUCED ORAL DISEASES USING SUGAR-FREE GUMS: A CONTROLLED CLINICAL TRIAL

  • María Cecilia Martínez Pabón Universidad de Antioquia http://orcid.org/0000-0002-8115-3089
  • Carolina Mesa Arango Universidad de Antioquia
  • Cecilia María Martínez Delgado Universidad de Antioquia
  • Maria Isabel Pérez Cano Universidad de Antioquia
  • Diana María Isaza Guzmán Universidad de Antioquia
  • Sergio Iván Tobón Arroyave Universidad de Antioquia
Keywords: Tooth decay, Chewing gum, Cariostatic agents, Adherence to treatment, Public health

Abstract

Introduction: the aim of this study was to assess the adherence to a preventive treatment of plaque-induced oral diseases using two sugar-free gums, establishing their effect on cariogenic bacteria counts as abiological marker of treatment response. Methods: a double-blind, randomized, parallel-group, controlled intervention study was conducted in 96 young adult university students in an experimental period of 30 days. Participants were distributed into two groups and given a chewing gum with either pentitol or hexitol + CPP-ACP complex to be taken three times a day for 20 minutes after conventional oral hygiene. Saliva samples were collected at baseline to evaluate counts of Streptococcus mutans (SM) and Lactobacillus spp. A survey was conducted at the end of the experimental period to assess the levels of adherence to treatment, remeasuring bacterial counts. Results: SM counts showed statistically significant differences between the study groups at the end of the experimental period, with a decreasing tendency in both groups. Intragroup difference was observed in patients who took pentitol gum with a marked reduction in SM counts. Conclusion: the final estimate of adherence to treatment showed that the type of chewing gum patients were given had no influence and therefore such gums can be used, considering the therapeutic agents that most contribute to patient’s particular case and preferences.

|Abstract
= 426 veces | PDF
= 27 veces|

Downloads

Download data is not yet available.

Author Biographies

María Cecilia Martínez Pabón, Universidad de Antioquia

DDS. MSc in Microbiology. School of Dentistry, Universidad de Antioquia, Medellín, Colombia

Carolina Mesa Arango, Universidad de Antioquia

DDS. School of Dentistry, Universidad de Antioquia, Medellín, Colombia

Cecilia María Martínez Delgado, Universidad de Antioquia

DDS. Specialist in Epidemiology. Master in University Management. School of Dentistry, Universidad de Antioquia, Medellín, Colombia

Maria Isabel Pérez Cano, Universidad de Antioquia

DDS. Specialist in Radiology. School of Dentistry, Universidad de Antioquia, Medellín, Colombia

Diana María Isaza Guzmán, Universidad de Antioquia

Bacteriologist. MSc in Basic Biomedical Sciences. School of Dentistry, Universidad de Antioquia, Medellín, Colombia

Sergio Iván Tobón Arroyave, Universidad de Antioquia

DDS. Stomatologist and Oral Surgeon. School of Dentistry, Universidad de Antioquia, Medellín, Colombia

References

Selwitz RH, Ismail AL, Pitts NB. Dental caries. Lancet. 2007; 369(9555): 51-9. DOI: https://doi.org/10.1016/

S0140-6736(07)60031-2

Petersen PE. The World Health Report 2003: continuous improvement of oral health in the 21st century the approach of the WHO Global Oral Health Programme. Community Dent Oral Epidemiol. 2003; 31(suppl 1): 3-23.

Syed M, Chopra R, Shrivastava V, Sachdev V. Comparative evaluation of 0.2% chlorhexidine mouthwash, xylitol chewing gum, and combination of 0.2% chlorhexidine mouthwash and xylitol chewing gum on salivary streptococcus mutans and biofilm levels in 8- to 12-year-old children. Int J Clin Pediatr Dent. 2016;9(4): 313-19. DOI: https://doi.org/10.5005/jp-journals-10005-1384

Riley P, Moore D, Ahmed F, Sharif MO, Worthington HV. Xylitol-containing products for preventing dental caries in children and adults. Cochrane Database Syst Rev. 2015; (3): CD010743. DOI: https://doi.org/10.1002/14651858.CD010743.pub2

Tuncer D, Onen A, Yazici AR. Effect of chewing gums with xylitol, sorbitol and xylitol-sorbitol on the remineralization and hardness of initial enamel lesions in situ. Dent Res J (Isfahan). 2014; 11(5): 537–43.

Chavan S, Lakashminarayan N, Kemparaj U. Effect of chewing xylitol containing and herbal chewing gums on salivary mutans streptococcus count among school children. Int J Prev Med. 2015; 6: 44. DOI: https://doi.org/10.4103/2008-7802.157543

Morgan MV, Adams GG, Bailey DL, Tsao CE, Fischman SL, et al. The anticariogenic effect of sugar-free gum containing CPP-ACP nanocomplexes on approximal caries determined using digital bitewing radiograbhy. Caries Res. 2008; 42(3): 171-84. DOI: https://doi.org/10.1159/000128561

International meeting on Adherence to Long-term Therapies. June 4-5, 2001. Genova: World Health Organization; 2001.

Haynes RB, Taylor DW, Sackett DL. Determinants of compliance. In: Haynes RB, Taylor DW, Sackett DL. Compliance in health care. Baltimore, USA: Johns Hopkins University Press; 1979. 104.

Mann NC; WHO. Improving adherence behavior with treatment regimens. Geneva: WHO. Division of Mental Health; 1993.

Martínez-Domínguez GI, Martínez-Sánchez LM, Lopera-Valle JS, Vargas-Grisales N. La importancia de la adherencia terapéutica. Rev Venez Endocrinol Metab. 2016; 14(2): 107-16.

Martínez-Pabón M, Duque-Agudelo L, Díaz-Gil JD, Isaza-Guzmán DM, Tobón-Arroyave SI. Comparison of the effect of two sugar-substituted chewing gums on different caries- and gingivitis-related variables: a

double-blind, randomized, controlled clinical trial. Clin Oral Investig. 2014; 18(2): 589-98. DOI: https://doi.org/10.1007/s00784-013-0989-0

Keukenmeester RS, Slot DE, Rosema NA, Van Loveren C, Van der Weijden GA. Effects of sugar-free chewing gum sweetened with xylitol or maltitol on the development of gingivitis and plaque: a randomized

clinical trial. Int J Dent Hyg. 2014; 12(4): 238-44. DOI: https://doi.org/10.1111/idh.12071

Ismail AI, Sohn W, Tellez M, Amaya A, Sen A, Hasson H, et al. The International Caries Detection and Assessment System (ICDAS): an integrated system for measuring dental caries. Community Dent Oral

Epidemiol. 2007; 35(3): 170-8. DOI: https://doi.org/10.1111/j.1600-0528.2007.00347.x

Morisky DE, Green LW, Levine DM. Concurrent and predictive validity of a self-reported measure of medication adherence. Med Care. 1986; 24(1): 67-74.

Kakodkar P, Mulay S. Effect of sugar-free gum in addition to tooth brushing on dental plaque and interdental debris. Dent Res J (Isfahan). 2010; 7(2): 64-9.

Feio M, Sapeta P. Xerostomia in palliative care. Acta Med Port. 2005; 18(6): 459-65.

Watthanasaen S, Merchant AT, Luengpailin S, Chansamak N, Pisek A, Pitiphat W. Xylitol-containing chewing gum for caries prevention in students with disabilities: a randomised trial. Oral Health Prev Dent.

; 15(6): 519–27. DOI: https://doi.org/10.3290/j.ohpd.a39668

Hashiba T, Takeuchi K, Shimazaki Y, Takeshita T, Yamashita Y. Chewing xylitol gum improves self-rated and objective indicators of oral health status under conditions interrupting regular oral hygiene. Tohoku J

Exp Med. 2015; 235(1): 39-46. DOI: https://doi.org/10.1620/tjem.235.39

Yengopal V, Mickenautsch S. Caries preventive effect of casein phosphopeptide-amorphous calcium phosphate (CPP-ACP): a meta-analysis. Acta Odontol Scand. 2009; 67(6): 321-32. DOI: https://doi.org/10.1080/00016350903160563

Correia D, Real Dias MC, Castanho Moacho A, Crispim P, Luis H, Oliveira M, et al. An association between temporomandibular disorder and gum chewing. Gen Dent. 2014; 62(6): e33-6.

Medrano J. Reflexiones nerviosas. Mascando (chicle) espero. Rev Asoc Esp Neuropsiq. 2011; 31(112): 755-63.

An J. The impact of patient-centered medical homes on quality of care and medication adherence in patients with Diabetes Mellitus. J Manag Care Spec Pharm. 2016; 22(11): 1272-84. DOI: https://doi.org/10.18553/jmcp.2016.22.11.1272

Peterson ME. Xylitol. Top Companion Anim Med. 2013; 28(1): 18-20. DOI: https://doi.org/10.1053/j.tcam.2013.03.008

Gurol-Urganci I, de-Jongh T, Vodopivec-Jamsek V, Atun R, Car J. Mobile phone messaging reminders for attendance at healthcare appointments. Cochrane Database Syst Rev. 2013; (12): CD007458. DOI: https://doi.org/10.1002/14651858.CD007458.pub3

Usherwood T. Encouraging adherence to long-term medication. Aust Prescr.2017; 40(4): 147-50. DOI: https://doi.org/10.18773/austprescr.2017.050

Siemer L, Brusse-Keizer MG, Postel MG, Ben Allouch S, Patrinopoulos Bougioukas A, Sanderman R, et al. Blended smoking cessation treatment: exploring measurement, levels, and predictors of adherence. J Med

Internet Res. 2018; 20(8): e246. DOI: https://doi.org/10.219/jmir.9969

Sarafino E, Smith T. Health-related behavior and health promotion. In: Sarafino E. Health psychology: biopsychosocial interactions. New York: John Wiley & Sons; 2014. 134.

Published
2019-07-09
How to Cite
Martínez Pabón, M. C., Mesa Arango, C., Martínez Delgado, C. M., Pérez Cano, M. I., Isaza Guzmán, D. M., & Tobón Arroyave, S. I. (2019). ASSESSMENT OF ADHERENCE TO PREVENTIVE TREATMENT OF PLAQUE-INDUCED ORAL DISEASES USING SUGAR-FREE GUMS: A CONTROLLED CLINICAL TRIAL. Revista Facultad De Odontología Universidad De Antioquia, 31(1-2). https://doi.org/10.17533/udea.rfo.v31n1-2a5