CYTOTOXIC LABDANE DITERPENOIDS ISOLATED FROM THE HEXANE FRACTION OF THE Croton stipuliformis STEM BARK

Authors

  • Martha S. FRANCO
  • Claudia P. CORDERO
  • Fabio ARISTIZABAL
  • Coralia OSORIO R. Universidad Nacional de Colombia

DOI:

https://doi.org/10.17533/udea.vitae.10067

Keywords:

<I>Croton stipuliformis</I>, Euphorbiaceae, labdane, MTT assay, cytotoxicity.

Abstract

The composition of the cytotoxic hexane fraction of the Croton stipuliformis bark was studied by means of a gas chromatography coupled to a mass spectrometry; sesquiterpenes and sterols were characterized as the main constituents. Along with these compounds, three labdane and seco-labdane diterpenoids, 8(17),12E,14-labdatrien-18-oic acid [3], 12E-3,4-seco-labda-4(18),8(17),12,14-tetraen-3-oic acid [2], and its methyl ester [1] were isolated from this fraction through preparative HPLC, and their structures were elucidated by HR-FABMS, 1D and 2D NMR analyses. Additionally, the cytotoxic activity of these three compounds against human tumor cell lines HEp-2, HT-29, MKN-45, MCF-7, and HeLa was assessed. The three compounds showed a non-specific and moderate cytotoxicity against the abovementioned cell lines.
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Author Biography

Coralia OSORIO R., Universidad Nacional de Colombia

Profesora Asociada, Departamento de Química, Universidad Nacional de Colombia

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Published

02-09-2011

How to Cite

FRANCO, M. S., CORDERO, C. P., ARISTIZABAL, F., & OSORIO R., C. (2011). CYTOTOXIC LABDANE DITERPENOIDS ISOLATED FROM THE HEXANE FRACTION OF THE <I>Croton stipuliformis</I> STEM BARK. Vitae, 18(2), 173–182. https://doi.org/10.17533/udea.vitae.10067

Issue

Section

Pharmacology and Toxicology

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