Complex, diclofenac, polymethylmethacrylate, solubility, ion pair.
Abstract
The acid-base interaction between a polyelectrolyte and an ionisable drug could lead to the formation ionic complexes. The resulting physicochemical properties of such nanostructures could reflect changes in solubility, stability and drug-release pattern. This study was aimed to establish if diclofenac solubility could be modified by the formation of Eudragit® E and diclofenac polyelectrolyte drug complexes, which were prepared through the solvent evaporation method. The solid state was characterized by infrared spectroscopy and X-ray powder diffraction, and solubility was determined. The results suggested that complexes were f
