Nucleic acid-based biosensors: analytical devices for prevention, diagnosis and treatment of diseases
Keywords:Biosensors, Nucleic acid-based biosensors, Bioreceptor, Diagnosis and monitoring of diseases, Biomarkers, Pathogens identification, Food safety
BACKGROUND : Biosensing techniques have been the subject of exponentially increasing interest due to their performance advantages such as high selectivity and sensitivity, easy operation, low cost, short analysis time, simple sample preparation, and real-time detection. Biosensors have been developed by integrating the unique specificity of biological reactions and the high sensitivity of physical sensors. Therefore, there has been a broad scope of applications for biosensing techniques, and nowadays, they are ubiquitous in different areas of environmental, healthcare, and food safety. Biosensors have been used for environmental studies, detecting and quantifying pollutants in water, air, and soil. Biosensors also showed great potential for developing analytical tools with countless applications in diagnosing, preventing, and treating diseases, mainly by detecting biomarkers. Biosensors as a medical device can identify nucleic acids, proteins, peptides, metabolites, etc.; these analytes may be biomarkers associated with the disease status. Bacterial food contamination is considered a worldwide public health issue; biosensor-based analytical techniques can identify the presence or absence of pathogenic agents in food. OBJECTIVES: The present review aims to establish state-of-the-art, comprising the recent advances in the use of nucleic acid-based biosensors and their novel application for the detection of nucleic acids. Emphasis will be given to the performance characteristics, advantages, and challenges. Additionally, food safety applications of nucleic acid-based biosensors will be discussed. METHODS: Recent research articles related to nucleic acid-based biosensors, biosensors for detecting nucleic acids, biosensors and food safety, and biosensors in environmental monitoring were reviewed. Also, biosensing platforms associated with the clinical diagnosis and food industry were included. RESULTS: It is possible to appreciate that multiple applications of nucleic acid-based biosensors have been reported in the diagnosis, prevention, and treatment of diseases, as well as to identify foodborne pathogenic bacteria. The use of PNA and aptamers opens the possibility of developing new biometric tools with better analytical properties. CONCLUSIONS: Biosensors could be considered the most important tool for preventing, treating, and monitoring diseases that significantly impact human health. The aptamers have advantages as biorecognition elements due to the structural conformation, hybridization capacity, robustness, stability, and lower costs. It is necessary to implement biosensors in situ to identify analytes with high selectivity and lower detection limits.
Kumar H, Kumari N, Sharma R. Nanocomposites (conducting polymer and nanoparticles) based electrochemical biosensor for the detection of environment pollutant: Its issues and challenges. Environ Impact Assess Rev 2020;85:106438. https://doi.org/10.1016/j.eiar.2020.106438.
Chang K, Deng S, Chen M. Novel biosensing methodologies for improving the detection of single nucleotide polymorphism. Biosens Bioelectron 2015;66:297–307. https://doi.org/10.1016/j.bios.2014.11.041.
Malhotra BD, Ali MA. Nanomaterials in Biosensors. Nanomater. Biosens., Elsevier; 2018, p. 1–74. https://doi.org/10.1016/B978-0-323-44923-6.00001-7.
Bhalla N, Jolly P, Formisano N, Estrela P. Introduction to biosensors. Essays Biochem 2016;60:1–8. https://doi.org/10.1042/EBC20150001.
Karunakaran C, Rajkumar R, Bhargava K. Introduction to Biosensors. Elsevier Inc.; 2015. https://doi.org/10.1016/B978-0-12-803100-1.00001-3.
Ensafi AA. An introduction to sensors and biosensors. Elsevier Inc.; 2019. https://doi.org/10.1016/B978-0-12-816491-4.00001-2.
Davis F, Altintas Z. General Introduction to Biosensors and Recognition Receptors. Biosens. Nanotechnol., Hoboken, NJ, USA: John Wiley & Sons, Inc.; 2017, p. 1–15. https://doi.org/10.1002/9781119065036.ch1.
Parmin NA, Hashim U, Gopinath SCB, Uda MNA. Biosensor recognizes the receptor molecules. Elsevier Inc.; 2018. https://doi.org/10.1016/B978-0-12-813900-4.00008-7.
Xiong E, Zhen D, Jiang L. Homogeneous enzyme-free and entropy-driven isothermal fluorescent assay for nucleic acids based on a dual-signal output amplification strategy. Chem Commun 2018;54:12594–7. https://doi.org/10.1039/C8CC07508E.
Kosack CS, Page AL, Klatser PR. A guide to aid the selection of diagnostic tests. Bull World Health Organ 2017;95:639–45. https://doi.org/10.2471/BLT.16.187468.
Moccia M, Caratelli V, Cinti S, Pede B, Avitabile C, Saviano M, et al. Paper-based electrochemical peptide nucleic acid (PNA) biosensor for detection of miRNA-492: a pancreatic ductal adenocarcinoma biomarker. Biosens Bioelectron 2020;165:112371. https://doi.org/10.1016/j.bios.2020.112371.
Hu Q, Wang Q, Sun G, Kong J, Zhang X. Electrochemically Mediated Surface-Initiated de Novo Growth of Polymers for Amplified Electrochemical Detection of DNA. Anal Chem 2017;89:9253–9. https://doi.org/10.1021/acs.analchem.7b02039.
Wang C, Liu J, Kong J, Zhang X. Nitronyl nitroxide monoradical TEMPO as new electrochemical label for ultrasensitive detection of nucleic acids. Anal Chim Acta 2020;1136:19–24. https://doi.org/10.1016/j.aca.2020.08.035.
Luo Y. Functional Nucleic Acid Based Biosensors for Food Safety Detection. 2018. https://doi.org/10.1007/978-981-10-8219-1.
Ribeiro BV, Cordeiro TAR, Oliveira e Freitas GR, Ferreira LF, Franco DL. Biosensors for the detection of respiratory viruses: A review. Talanta Open 2020;2:100007. https://doi.org/10.1016/j.talo.2020.100007.
Sergeev N V., Herold KE, Rasooly A. Regulatory and Validation Issues for Biosensors and Related Bioanalytical Technologies. Handb. Biosens. Biochips, Chichester, UK: John Wiley & Sons, Ltd; 2008. https://doi.org/10.1002/9780470061565.hbb132.
Migliozzi D, Guibentif T. Assessing the potential deployment of biosensors for point-of-care diagnostics in developing countries: Technological, economic and regulatory aspects. Biosensors 2018;8. https://doi.org/10.3390/bios8040119.
Clark LC, Lyons C. ELECTRODE SYSTEMS FOR CONTINUOUS MONITORING IN CARDIOVASCULAR SURGERY. Ann N Y Acad Sci 1962;102:29–45. https://doi.org/10.1111/j.1749-6632.1962.tb13623.x.
Davis F, Higson SPJ. Structured thin films as functional components within biosensors. Biosens Bioelectron 2005;21:1–20. https://doi.org/10.1016/j.bios.2004.10.001.
Díaz-González M, González-García MB, Costa-García A. Recent Advances in Electrochemical Enzyme Immunoassays. Electroanalysis 2005;17:1901–18. https://doi.org/10.1002/elan.200503357.
Rodriguez-Mozaz S, Lopez de Alda MJ, Barceló D. Biosensors as useful tools for environmental analysis and monitoring. Anal Bioanal Chem 2006;386:1025–41. https://doi.org/10.1007/s00216-006-0574-3.
Scognamiglio V, Pezzotti G, Pezzotti I, Cano J, Buonasera K, Giannini D, et al. Biosensors for effective environmental and agrifood protection and commercialization: From research to market. Microchim Acta 2010;170:215–25. https://doi.org/10.1007/s00604-010-0313-5.
Li J, Stachowski M, Zhang Z. Application of responsive polymers in implantable medical devices and biosensors. Switch. Responsive Surfaces Mater. Biomed. Appl., Elsevier Inc.; 2015, p. 259–98. https://doi.org/10.1016/B978-0-85709-713-2.00011-0.
Vasala A, Hytönen VP, Laitinen OH. Modern Tools for Rapid Diagnostics of Antimicrobial Resistance. Front Cell Infect Microbiol 2020;10. https://doi.org/10.3389/fcimb.2020.00308.
Ahmed A, Rushworth J V., Hirst NA, Millner PA. Biosensors for whole-cell bacterial detection. Clin Microbiol Rev 2014;27:631–46. https://doi.org/10.1128/CMR.00120-13.
Habli Z, Alchamaa W, Saab R, Kadara H, Khraiche ML. Circulating tumor cell detection technologies and clinical utility: Challenges and opportunities. Cancers (Basel) 2020;12:1–30. https://doi.org/10.3390/cancers12071930.
Wibowo KM, Muslihati A, Sahdan MZ, Rosni NM, Basri H, Fudholi A. A novel, portable Escherichia coli bacteria sensor using graphene as sensing material. Mater Chem Phys 2020;254:123459. https://doi.org/10.1016/j.matchemphys.2020.123459.
Guo J, Liu D, Yang Z, Weng W, Chan EWC, Zeng Z, et al. A photoelectrochemical biosensor for rapid and ultrasensitive norovirus detection. Bioelectrochemistry 2020;136:107591. https://doi.org/10.1016/j.bioelechem.2020.107591.
Vermisoglou E, Panáček D, Jayaramulu K, Pykal M, Frébort I, Kolář M, et al. Human virus detection with graphene-based materials. Biosens Bioelectron 2020;166:112436. https://doi.org/10.1016/j.bios.2020.112436.
Sá SR, Silva Junior AG, Lima-Neto RG, Andrade CAS, Oliveira MDL. Lectin-based impedimetric biosensor for differentiation of pathogenic candida species. Talanta 2020;220:121375. https://doi.org/10.1016/j.talanta.2020.121375.
Deepa, Pundir S, Pundir CS. Detection of tumor suppressor protein p53 with special emphasis on biosensors: A review. Anal Biochem 2020;588:113473. https://doi.org/10.1016/j.ab.2019.113473.
Hou L, Huang Y, Hou W, Yan Y, Liu J, Xia N. Modification-free amperometric biosensor for the detection of wild-type p53 protein based on the in situ formation of silver nanoparticle networks for signal amplification. Int J Biol Macromol 2020;158:580–6. https://doi.org/10.1016/j.ijbiomac.2020.04.271.
Ameri M, Shabaninejad Z, Movahedpour A, Sahebkar A, Mohammadi S, Hosseindoost S, et al. Biosensors for detection of Tau protein as an Alzheimer’s disease marker. Int J Biol Macromol 2020;162:1100–8. https://doi.org/10.1016/j.ijbiomac.2020.06.239.
Sohrabi H, kholafazad Kordasht H, Pashazadeh-Panahi P, Nezhad-Mokhtari P, Hashemzaei M, Majidi MR, et al. Recent advances of electrochemical and optical biosensors for detection of C-reactive protein as a major inflammatory biomarker. Microchem J 2020;158:105287. https://doi.org/10.1016/j.microc.2020.105287.
Sars-cov- S, Mavrikou S, Moschopoulou G, Tsekouras V. Protein Antigen 2020.
Samson R, Navale GR, Dharne MS. Biosensors: frontiers in rapid detection of COVID-19. 3 Biotech 2020;10:385. https://doi.org/10.1007/s13205-020-02369-0.
Xing Y, Xia N. Biosensors for the Determination of Amyloid-Beta Peptides and their Aggregates with Application to Alzheimer’s Disease. Anal Lett 2015;48:879–93. https://doi.org/10.1080/00032719.2014.968925.
Boschetti E, D’Amato A, Candiano G, Righetti PG. Protein biomarkers for early detection of diseases: The decisive contribution of combinatorial peptide ligand libraries. J Proteomics 2018;188:1–14. https://doi.org/10.1016/j.jprot.2017.08.009.
Li J, Zhu Y, Wu X, Hoffmann MR. Rapid detection methods for bacterial pathogens in ambient waters at the point of sample collection: A brief review. Clin Infect Dis 2020;71:S84–90. https://doi.org/10.1093/cid/ciaa498.
Jiang Y, Qiu Z, Le T, Zou S, Cao X. Developing a dual-RCA microfluidic platform for sensitive E. coli O157:H7 whole-cell detections. Anal Chim Acta 2020;1127:79–88. https://doi.org/10.1016/j.aca.2020.06.046.
Farooq U, Ullah MW, Yang Q, Aziz A, Xu J, Zhou L, et al. High-density phage particles immobilization in surface-modified bacterial cellulose for ultra-sensitive and selective electrochemical detection of Staphylococcus aureus. Biosens Bioelectron 2020;157:112163. https://doi.org/10.1016/j.bios.2020.112163.
Keshavarz A, Zangenehzadeh S, Hatef A. Optimization of surface plasmon resonance-based biosensors for monitoring hemoglobin levels in human blood. Appl Nanosci 2020;10:1465–74. https://doi.org/10.1007/s13204-020-01252-x.
Mehrotra P. Biosensors and their applications - A review. J Oral Biol Craniofacial Res 2016;6:153–9. https://doi.org/10.1016/j.jobcr.2015.12.002.
Giuliano KA, Taylor DL. Fluorescent-protein biosensors: New tools for drug discovery. Trends Biotechnol 1998;16:135–40. https://doi.org/10.1016/S0167-7799(97)01166-9.
Wolff M, Wiedenmann J, Nienhaus GU, Valler M, Heilker R. Novel fluorescent proteins for high-content screening. Drug Discov Today 2006;11:1054–60. https://doi.org/10.1016/j.drudis.2006.09.005.
Lang P, Yeow K, Nichols A, Scheer A. Cellular imaging in drug discovery. Nat Rev Drug Discov 2006;5:343–56. https://doi.org/10.1038/nrd2008.
El-Deiry WS, Sigman CC, Kelloff GJ. Imaging and oncologic drug development. J Clin Oncol 2006;24:3261–73. https://doi.org/10.1200/JCO.2006.06.5623.
Willmann JK, van Bruggen N, Dinkelborg LM, Gambhir SS. Molecular imaging in drug development. Nat Rev Drug Discov 2008;7:591–607. https://doi.org/10.1038/nrd2290.
Nandimandalam H, Gude VG. Indigenous biosensors for in situ hydrocarbon detection in aquatic environments. Mar Pollut Bull 2019;149:110643. https://doi.org/10.1016/j.marpolbul.2019.110643.
Barel-Cohen K, Shore LS, Shemesh M, Wenzel A, Mueller J, Kronfeld-Schor N. Monitoring of natural and synthetic hormones in a polluted river. J Environ Manage 2006;78:16–23. https://doi.org/10.1016/j.jenvman.2005.04.006.
Nozaki O. Steroid analysis for medical diagnosis. J Chromatogr A 2001;935:267–78. https://doi.org/10.1016/S0021-9673(01)01104-9.
Ying GG, Kookana RS, Ru YJ. Occurrence and fate of hormone steroids in the environment. Environ Int 2002;28:545–51. https://doi.org/10.1016/S0160-4120(02)00075-2.
Wegener HC. Antibiotics in animal feed and their role in resistance development. Curr Opin Microbiol 2003;6:439–45. https://doi.org/10.1016/j.mib.2003.09.009.
Sumpter JP, Jobling S. Vitellogenesis as a biomarker for estrogenic contamination of the aquatic environment. Environ. Health Perspect., vol. 103, Public Health Services, US Dept of Health and Human Services; 1995, p. 173–8. https://doi.org/10.1289/ehp.95103s7173.
Adrián J, Fernández F, Muriano A, Obregon R, Ramón-Azcon J, Tort N, et al. Biosensors for Pharmaceuticals and Emerging Contaminants Based on Novel Micro and Nanotechnology Approaches. Handb. Environ. Chem. Vol. 5 Water Pollut., vol. 5 J, 2009, p. 47–68. https://doi.org/10.1007/978-3-540-36253-1_3.
Lu X, Sun J, Sun X. Recent advances in biosensors for the detection of estrogens in the environment and food. TrAC - Trends Anal Chem 2020;127:115882. https://doi.org/10.1016/j.trac.2020.115882.
Kim YS, Jung HS, Matsuura T, Lee HY, Kawai T, Gu MB. Electrochemical detection of 17β-estradiol using DNA aptamer immobilized gold electrode chip. Biosens Bioelectron 2007;22:2525–31. https://doi.org/10.1016/j.bios.2006.10.004.
Jo M, Ahn JY, Lee J, Lee S, Hong SW, Yoo JW, et al. Development of single-stranded DNA aptamers for specific bisphenol a detection. Oligonucleotides 2011;21:85–91. https://doi.org/10.1089/oli.2010.0267.
Ma Y, Liu J, Li H. Diamond-based electrochemical aptasensor realizing a femtomolar detection limit of bisphenol A. Biosens Bioelectron 2017;92:21–5. https://doi.org/10.1016/j.bios.2017.01.041.
Abnous K, Danesh NM, Ramezani M, Alibolandi M, Taghdisi SM. A novel electrochemical sensor for bisphenol A detection based on nontarget-induced extension of aptamer length and formation of a physical barrier. Biosens Bioelectron 2018;119:204–8. https://doi.org/10.1016/j.bios.2018.08.024.
Nameghi MA, Danesh NM, Ramezani M, Alibolandi M, Abnous K, Taghdisi SM. An ultrasensitive electrochemical sensor for 17β-estradiol using split aptamers. Anal Chim Acta 2019;1065:107–12. https://doi.org/10.1016/j.aca.2019.02.062.
Rathnayake IVN, Megharaj M, Naidu R. Green fluorescent protein based whole cell bacterial biosensor for the detection of bioavailable heavy metals in soil environment. Environ Technol Innov 2021;23:101785. https://doi.org/10.1016/j.eti.2021.101785.
Tian M, Qiao M, Shen C, Meng F, Frank LA, Krasitskaya V V., et al. Highly-sensitive graphene field effect transistor biosensor using PNA and DNA probes for RNA detection. Appl Surf Sci 2020;527. https://doi.org/10.1016/j.apsusc.2020.146839.
Carpenter AC, Paulsen IT, Williams TC. Blueprints for biosensors: Design, limitations, and applications. Genes (Basel) 2018;9. https://doi.org/10.3390/genes9080375.
Ozer T, Geiss BJ, Henry CS. Review—Chemical and Biological Sensors for Viral Detection. J Electrochem Soc 2020;167:037523. https://doi.org/10.1149/2.0232003jes.
Wu Q, Zhang Y, Yang Q, Yuan N, Zhang W. Review of Electrochemical DNA Biosensors for Detecting Food Borne Pathogens. Sensors 2019;19:4916. https://doi.org/10.3390/s19224916.
Palchetti I, Bettazzi F. Nucleic Acid-Based Sensors. Encycl. Interfacial Chem., vol. 80, Elsevier; 2018, p. 392–402. https://doi.org/10.1016/B978-0-12-409547-2.13487-0.
Gaudin V. Advances in biosensor development for the screening of antibiotic residues in food products of animal origin – A comprehensive review. Biosens Bioelectron 2017;90:363–77. https://doi.org/10.1016/j.bios.2016.12.005.
Yan M, Bai W, Zhu C, Huang Y, Yan J, Chen A. Design of nuclease-based target recycling signal amplification in aptasensors. Biosens Bioelectron 2016;77:613–23. https://doi.org/10.1016/j.bios.2015.10.015.
Dembowski SK, Bowser MT. CE-SELEX : Rapid Aptamer Selection Using Capillary Electrophoresis. Sciex 2016:1–10.
Kim YS, Kim JH, Kim IA, Lee SJ, Jurng J, Gu MB. A novel colorimetric aptasensor using gold nanoparticle for a highly sensitive and specific detection of oxytetracycline. Biosens Bioelectron 2010;26:1644–9. https://doi.org/10.1016/j.bios.2010.08.046.
Chang YC, Yang CY, Sun RL, Cheng YF, Kao WC, Yang PC. Rapid single cell detection of Staphylococcus aureus by aptamer-conjugated gold nanoparticles. Sci Rep 2013;3:1–7. https://doi.org/10.1038/srep01863.
Wu Y, Zhan S, Wang L, Zhou P. Selection of a DNA aptamer for cadmium detection based on cationic polymer mediated aggregation of gold nanoparticles. Analyst 2014;139:1550–61. https://doi.org/10.1039/c3an02117c.
Luo Y, Xu J, Li Y, Gao H, Guo J, Shen F, et al. A novel colorimetric aptasensor using cysteamine-stabilized gold nanoparticles as probe for rapid and specific detection of tetracycline in raw milk. Food Control 2015;54:7–15. https://doi.org/10.1016/j.foodcont.2015.01.005.
Zhang K, Wang K, Zhu X, Xie M, Xu F. A label-free kissing complex-induced fluorescence sensor for DNA and RNA detection by using DNA-templated silver nanoclusters as a signal transducer. RSC Adv 2016;6:99269–73. https://doi.org/10.1039/C6RA22515B.
Andrea E, Robert B. Riboswitches: A Common RNA Regulatory Element. 2010, Nat Educ 3(9)9 n.d.
Findeiß S, Etzel M, Will S, Mörl M, Stadler PF. Design of artificial riboswitches as biosensors. Sensors (Switzerland) 2017;17:1–28. https://doi.org/10.3390/s17091990.
Barrick JE, Breaker RR. The distributions, mechanisms, and structures of metabolite-binding riboswitches. Genome Biol 2007;8. https://doi.org/10.1186/gb-2007-8-11-r239.
Cromie MJ, Shi Y, Latifi T, Groisman EA. An RNA Sensor for Intracellular Mg2+. Cell 2006;125:71–84. https://doi.org/10.1016/j.cell.2006.01.043.
Machtel P, Bąkowska-Żywicka K, Żywicki M. Emerging applications of riboswitches – from antibacterial targets to molecular tools. J Appl Genet 2016;57:531–41. https://doi.org/10.1007/s13353-016-0341-x.
Fowler CC, Brown ED, Li Y. Using a riboswitch sensor to examine coenzyme B12 metabolism and transport in E. coli. Chem Biol 2010;17:756–65. https://doi.org/10.1016/j.chembiol.2010.05.025.
Wittung P, Nielsen PE, Buchardt O, Egholm M, Norde´n B. DNA-like double helix formed by peptide nucleic acid. Nature 1994;368:561–3. https://doi.org/10.1038/368561a0.
Briones C, Moreno M. Applications of peptide nucleic acids (PNAs) and locked nucleic acids (LNAs) in biosensor development. Anal Bioanal Chem 2012;402:3071–89. https://doi.org/10.1007/s00216-012-5742-z.
Sharma C, Awasthi SK. Versatility of peptide nucleic acids (PNAs): role in chemical biology, drug discovery, and origins of life. Chem Biol Drug Des 2017;89:16–37. https://doi.org/10.1111/cbdd.12833.
Kapoor PKD, Richards SD, Kumar BN. PNA Beacons for Duplex DNA. C Bull Otorhinolaryngol Head Neck Surg 2001;5:71.
Lundin KE, Good L, Strömberg R, Gräslund A, Smith CIE. Biological Activity and Biotechnological Aspects of Peptide Nucleic Acid. Adv Genet 2006;56:1–51. https://doi.org/10.1016/S0065-2660(06)56001-8.
D’Agata R, Giuffrida MC, Spoto G. Peptide Nucleic Acid-Based Biosensors for Cancer Diagnosis. Molecules 2017;22:1–15. https://doi.org/10.3390/molecules22111951.
Saadati A, Hassanpour S, Guardia M de la, Mosafer J, Hashemzaei M, Mokhtarzadeh A, et al. Recent advances on application of peptide nucleic acids as a bioreceptor in biosensors development. TrAC - Trends Anal Chem 2019;114:56–68. https://doi.org/10.1016/j.trac.2019.02.030.
Cai B, Wang S, Huang L, Ning Y, Zhang Z, Zhang GJ. Ultrasensitive label-free detection of PNA-DNA hybridization by reduced graphene oxide field-effect transistor biosensor. ACS Nano 2014;8:2632–8. https://doi.org/10.1021/nn4063424.
Bora U. Nucleic Acid Based Biosensors for Clinical Applications. Biosens J 2013;02:1–8. https://doi.org/10.4172/2090-4967.1000104.
Varadan VK, Chen L, Xie J. Nanomedicine: Design and Applications of Magnetic Nanomaterials, Nanosensors and Nanosystems. vol. 53. John Wiley & Sons, 2008; 2012. https://doi.org/10.1080/00107514.2012.686521.
Herne TM, Tarlov MJ. Characterization of DNA Probes Immobilized on Gold Surfaces. J Am Chem Soc 1997;119:8916–20. https://doi.org/10.1021/ja9719586.
Bhardwaj T. A Review on Immobilization Techniques of Biosensors. Int J Eng Res Technol 2014;3:294–8.
Mo L, Li J, Liu Q, Qiu L, Tan W. Nucleic acid-functionalized transition metal nanosheets for biosensing applications. Biosens Bioelectron 2017;89:201–11. https://doi.org/10.1016/j.bios.2016.03.044.
Cui X, Pei R, Wang Z, Yang F, Ma Y, Dong S, et al. Layer-by-layer assembly of multilayer films composed of avidin and biotin-labeled antibody for immunosensing. Biosens Bioelectron 2003;18:59–67. https://doi.org/10.1016/S0956-5663(02)00114-8.
Zhu C, Zeng Z, Li H, Li F, Fan C, Zhang H. Single-layer MoS2-based nanoprobes for homogeneous detection of biomolecules. J Am Chem Soc 2013;135:5998–6001. https://doi.org/10.1021/ja4019572.
Zhang Y, Zheng B, Zhu C, Zhang X, Tan C, Li H, et al. Single-layer transition metal dichalcogenide nanosheet-based nanosensors for rapid, sensitive, and multiplexed detection of DNA. Adv Mater 2015;27:935–9. https://doi.org/10.1002/adma.201404568.
Liu S, Zheng Z, Li X. Advances in pesticide biosensors: Current status, challenges, and future perspectives. Anal Bioanal Chem 2013;405:63–90. https://doi.org/10.1007/s00216-012-6299-6.
Wang L, Guo W, Zhu H, He H, Wang S. Preparation and properties of a dual-function cellulose nanofiber-based bionic biosensor for detecting silver ions and acetylcholinesterase. J Hazard Mater 2021;403:123921. https://doi.org/10.1016/j.jhazmat.2020.123921.
Jain A, Cheng K. The principles and applications of avidin-based nanoparticles in drug delivery and diagnosis. J Control Release 2017;245:27–40. https://doi.org/10.1016/j.jconrel.2016.11.016.
Chung D-J, Kim K-C, Choi S-H. Electrochemical DNA biosensor based on avidin–biotin conjugation for influenza virus (type A) detection. Appl Surf Sci 2011;257:9390–6. https://doi.org/10.1016/j.apsusc.2011.06.015.
Terse-Thakoor T, Ramnani P, Villarreal C, Yan D, Tran TT, Pham T, et al. Graphene nanogap electrodes in electrical biosensing. Biosens Bioelectron 2019;126:838–44. https://doi.org/10.1016/j.bios.2018.11.049.
Hashkavayi AB, Raoof JB. Nucleic acid–based electrochemical biosensors. Electrochem. Biosens., Elsevier; 2019, p. 253–76. https://doi.org/10.1016/B978-0-12-816491-4.00009-7.
Ma C, Zhang M, Chen S, Liang C, Shi C. Rapid and enzyme-free nucleic acid detection based on exponential hairpin assembly in complex biological fluids. Analyst 2016;141:2883–6. https://doi.org/10.1039/c6an00474a.
Lu JJ, Ma JQ, Yi JM, Shen ZL, Zhong YJ, Ma CA, et al. Electrochemical polymerization of pyrrole containing TEMPO side chain on pt electrode and its electrochemical activity. Electrochim Acta 2014;130:412–7. https://doi.org/10.1016/j.electacta.2014.03.028.
Sinawang PD, Fajs L, Elouarzaki K, Nugraha J, Marks RS. TEMPO-based immuno-lateral flow quantitative detection of dengue NS1 protein. Sensors Actuators, B Chem 2018;259:354–63. https://doi.org/10.1016/j.snb.2017.12.043.
Lin MS, Chen WC, Huang JX, Gao HJ, Sheng HH. Aberrant expression of microRNAs in serum may identify individuals with pancreatic cancer. Int J Clin Exp Med 2014;7:5226–34.
Pei Z, Liu S-M, Huang J-T, Zhang X, Yan D, Xia Q, et al. Clinically relevant circulating microRNA profiling studies in pancreatic cancer using meta-analysis. Oncotarget 2017;8:22616–24. https://doi.org/10.18632/oncotarget.15148.
Vincent A, Herman J, Schulick R, Hruban RH, Goggins M. Pancreatic cancer. Lancet, vol. 378, 2011, p. 607–20. https://doi.org/10.1016/S0140-6736(10)62307-0.
McGuigan A, Kelly P, Turkington RC, Jones C, Coleman HG, McCain RS. Pancreatic cancer: A review of clinical diagnosis, epidemiology, treatment and outcomes. World J Gastroenterol 2018;24:4846–61. https://doi.org/10.3748/wjg.v24.i43.4846.
Moutinho-Ribeiro P, Macedo G, Melo SA. Pancreatic cancer diagnosis and management: Has the time come to prick the bubble? Front Endocrinol (Lausanne) 2019;10. https://doi.org/10.3389/fendo.2018.00779.
Nielsen P, Egholm M, Berg R, Buchardt O. Sequence-selective recognition of DNA by strand displacement with a thymine-substituted polyamide. Science (80- ) 1991;254:1497–500. https://doi.org/10.1126/science.1962210.
Cinti S, Moscone D, Arduini F. Preparation of paper-based devices for reagentless electrochemical (bio)sensor strips. Nat Protoc 2019;14:2437–51. https://doi.org/10.1038/s41596-019-0186-y.
Li F, Dong Y, Zhang Z, Lv M, Wang Z, Ruan X, et al. A recyclable biointerface based on cross-linked branched DNA nanostructures for ultrasensitive nucleic acid detection. Biosens Bioelectron 2018;117:562–6. https://doi.org/10.1016/j.bios.2018.06.053.
John J, Hugar KM, Rivera-Meléndez J, Kostalik HA, Rus ED, Wang H, et al. An Electrochemical Quartz Crystal Microbalance Study of a Prospective Alkaline Anion Exchange Membrane Material for Fuel Cells: Anion Exchange Dynamics and Membrane Swelling. J Am Chem Soc 2014;136:5309–22. https://doi.org/10.1021/ja4117457.
Pei H, Lu N, Wen Y, Song S, Liu Y, Yan H, et al. A DNA nanostructure-based biomolecular probe carrier platform for electrochemical biosensing. Adv Mater 2010;22:4754–8. https://doi.org/10.1002/adma.201002767.
De Luna P, Mahshid SS, Das J, Luan B, Sargent EH, Kelley SO, et al. High-Curvature Nanostructuring Enhances Probe Display for Biomolecular Detection. Nano Lett 2017;17:1289–95. https://doi.org/10.1021/acs.nanolett.6b05153.
Sheehan PE, Whitman LJ. Detection limits for nanoscale biosensors. Nano Lett 2005;5:803–7. https://doi.org/10.1021/nl050298x.
Squires TM, Messinger RJ, Manalis SR. Making it stick: Convection, reaction and diffusion in surface-based biosensors. Nat Biotechnol 2008;26:417–26. https://doi.org/10.1038/nbt1388.
Tedeschi T, Tonelli A, Sforza S, Corradini R, Marchelli R. A pyrenyl-PNA probe for DNA and RNA recognition: Fluorescence and UV absorption studies. Artif DNA PNA XNA 2010;1:83–9. https://doi.org/10.4161/adna.1.2.13899.
Xu S, Zhang C, Jiang S, Hu G, Li X, Zou Y, et al. Graphene foam field-effect transistor for ultra-sensitive label-free detection of ATP. Sensors Actuators, B Chem 2019;284:125–33. https://doi.org/10.1016/j.snb.2018.12.129.
Agashe V, Shenai S, Mohrir G, Deshmukh M, Bhaduri A, Deshpande R, et al. Osteoarticular tuberculosis - Diagnostic solutions in a disease endemic region. J Infect Dev Ctries 2009;3:511–6. https://doi.org/10.3855/jidc.469.
Yen P-W, Lu Y-P, Lin C-T, Hwang C-H, Yeh J, Lin M-Y, et al. Emerging Electrical Biosensors for Detecting Pathogens and Antimicrobial Susceptibility Tests. Curr Org Chem 2014;18:165–72. https://doi.org/10.2174/13852728113176660140.
Moulin E, Selby K, Cherpillod P, Kaiser L, Boillat-Blanco N. Simultaneous outbreaks of dengue, chikungunya and Zika virus infections: Diagnosis challenge in a returning traveller with nonspecific febrile illness. New Microbes New Infect 2016;11:6–7. https://doi.org/10.1016/j.nmni.2016.02.003.
Priyamvada L, Quicke KM, Hudson WH, Onlamoon N, Sewatanon J, Edupuganti S, et al. Human antibody responses after dengue virus infection are highly cross-reactive to Zika virus. Proc Natl Acad Sci U S A 2016;113:7852–7. https://doi.org/10.1073/pnas.1607931113.
Dejnirattisai W, Supasa P, Wongwiwat W, Rouvinski A, Barba-Spaeth G, Duangchinda T, et al. Dengue virus sero-cross-reactivity drives antibody-dependent enhancement of infection with zika virus. Nat Immunol 2016;17:1102–8. https://doi.org/10.1038/ni.3515.
Xie B-P, Qiu G-H, Hu P-P, Liang Z, Liang Y-M, Sun B, et al. Simultaneous detection of Dengue and Zika virus RNA sequences with a three-dimensional Cu-based zwitterionic metal–organic framework, comparison of single and synchronous fluorescence analysis. Sensors Actuators B Chem 2018;254:1133–40. https://doi.org/10.1016/j.snb.2017.06.085.
Ye T, Liu Y, Luo M, Xiang X, Ji X, Zhou G, et al. Metal–organic framework-based molecular beacons for multiplexed DNA detection by synchronous fluorescence analysis. Analyst 2014;139:1721–5. https://doi.org/10.1039/c3an02077k.
Kumar P, Deep A, Kim KH. Metal organic frameworks for sensing applications. TrAC - Trends Anal Chem 2015;73:39–53. https://doi.org/10.1016/j.trac.2015.04.009.
Zhu X, Zheng H, Wei X, Lin Z, Guo L, Qiu B, et al. Metal-organic framework (MOF): A novel sensing platform for biomolecules. Chem Commun 2013;49:1276–8. https://doi.org/10.1039/c2cc36661d.
Zhang HT, Zhang JW, Huang G, Du ZY, Jiang HL. An amine-functionalized metal–organic framework as a sensing platform for DNA detection. Chem Commun 2014;50:12069–72. https://doi.org/10.1039/c4cc05571c.
Huo B, Hu Y, Gao Z, Li G. Recent advances on functional nucleic acid-based biosensors for detection of food contaminants. Talanta 2021;222:121565. https://doi.org/10.1016/j.talanta.2020.121565.
Vidic J, Vizzini P, Manzano M, Kavanaugh D, Ramarao N, Zivkovic M, et al. Point-of-need DNA testing for detection of foodborne pathogenic bacteria. Sensors (Switzerland) 2019;19. https://doi.org/10.3390/s19051100.
Yousefi H, Ali MM, Su HM, Filipe CDM, Didar TF. Sentinel Wraps: Real-Time Monitoring of Food Contamination by Printing DNAzyme Probes on Food Packaging. ACS Nano 2018;12:3287–94. https://doi.org/10.1021/acsnano.7b08010.
Li S, Liu S, Xu Y, Zhang R, Zhao Y, Qu X, et al. Robust and highly specific fluorescence sensing of: Salmonella typhimurium based on dual-functional phi29 DNA polymerase-mediated isothermal circular strand displacement polymerization. Analyst 2019;144:4795–802. https://doi.org/10.1039/c9an00843h.
Eurosurveillance editorial team. The European Union summary report on trends and sources of zoonoses, zoonotic agents and food-borne outbreaks in 2010. Euro Surveill 2012;17. https://doi.org/10.2903/j.efsa.2012.2597.
Shen H, Wang J, Liu H, Li Z, Jiang F, Wang FB, et al. Rapid and Selective Detection of Pathogenic Bacteria in Bloodstream Infections with Aptamer-Based Recognition. ACS Appl Mater Interfaces 2016;8:19371–8. https://doi.org/10.1021/acsami.6b06671.
Chen Z, Liu Y, Xin C, Zhao J, Liu S. A cascade autocatalytic strand displacement amplification and hybridization chain reaction event for label-free and ultrasensitive electrochemical nucleic acid biosensing. Biosens Bioelectron 2018;113:1–8. https://doi.org/10.1016/j.bios.2018.04.046.
Endo MS, Signoretti FGC, Kitayama VS, Marinho ACS, Martinho FC, Gomes BPFDA. Investigation in vivo of enterococcus faecalis in endodontic retreatment by phenotypic and genotypic methods. Acta Sci - Heal Sci 2015;37:95–103. https://doi.org/10.4025/actascihealthsci.v37i1.24348.
Kim HS, Hahn H, Kim J, Jang DM, Lee JY, Back JM, et al. Structural basis for the substrate recognition of peptidoglycan pentapeptides by Enterococcus faecalis VanYB. Int J Biol Macromol 2018;119:335–44. https://doi.org/10.1016/j.ijbiomac.2018.07.081.
de Lucena JMVM, Decker EM, Walter C, Boeira LS, Löst C, Weiger R. Antimicrobial effectiveness of intracanal medicaments on Enterococcus faecalis : chlorhexidine versus octenidine. Int Endod J 2013;46:53–61. https://doi.org/10.1111/j.1365-2591.2012.02093.x.
Oesterle ME, Wright K, Fidler M, Johnson P, Bialonska D. Are ball pits located in physical therapy clinical settings a source of pathogenic microorganisms? Am J Infect Control 2019;47:456–8. https://doi.org/10.1016/j.ajic.2018.09.031.
Giraffa G. Enterococci from foods. FEMS Microbiol Rev 2002;26:163–71. https://doi.org/10.1111/j.1574-6976.2002.tb00608.x.
Andrighetto C, Knijff E, Lombardi A, Torriani S, Vancanneyt M, Kersters K, et al. Phenotypic and genetic diversity of enterococci isolated from Italian cheeses. J Dairy Res 2001;68:303–16. https://doi.org/10.1017/S0022029901004800.
Oprea SF, Zervos MJ. Enterococcus and its Association with Foodborne Illness. Foodborne Dis., 2007, p. 157–74. https://doi.org/10.1007/978-1-59745-501-5_6.
Abkar M, Alamian S, Sattarahmady N. A comparison between adjuvant and delivering functions of calcium phosphate, aluminum hydroxide and chitosan nanoparticles, using a model protein of Brucella melitensis Omp31. Immunol Lett 2019;207:28–35. https://doi.org/10.1016/j.imlet.2019.01.010.
Gorgizadeh M, Azarpira N, Sattarahmady N. In vitro and in vivo tumor annihilation by near-infrared photothermal effect of a NiFe2O4/C nanocomposite. Colloids Surfaces B Biointerfaces 2018;170:393–400. https://doi.org/10.1016/j.colsurfb.2018.06.034.
Gorgizadeh M, Azarpira N, Dehdari Veis R, Sattarahmady N. Repression of melanoma tumor in vitro and in vivo by photothermal effect of carbon xerogel nanoparticles. Colloids Surfaces B Biointerfaces 2019;176:449–55. https://doi.org/10.1016/j.colsurfb.2019.01.032.
Negahdary M, Behjati-Ardakani M, Sattarahmady N, Heli H. An aptamer-based biosensor for troponin i detection in diagnosis of myocardial infarction. J Biomed Phys Eng 2018;8:167–78. https://doi.org/10.22086/jbpe.v0i0.930.
Sattarahmady N, Rezaie-Yazdi M, Tondro GH, Akbari N. Bactericidal laser ablation of carbon dots: An in vitro study on wild-type and antibiotic-resistant Staphylococcus aureus. J Photochem Photobiol B Biol 2017;166:323–32. https://doi.org/10.1016/j.jphotobiol.2016.12.006.
Sattarahmady N, Firoozabadi V, Nazari-Vanani R, Azarpira N. Investigation of amyloid formation inhibition of chemically and biogenically from Citrus aurantium L. blossoms and Rose damascena oils of gold nanoparticles: Toxicity evaluation in rat pheochromocytoma PC12 cells. Int J Biol Macromol 2018;112:703–11. https://doi.org/10.1016/j.ijbiomac.2018.02.025.
Nazari-Vanani R, Sattarahmady N, Yadegari H, Khatami M, Heli H. Electrochemical biosensing of 16s rRNA gene sequence of Enterococcus faecalis. Biosens Bioelectron 2019;142:111541. https://doi.org/10.1016/j.bios.2019.111541.
Heli H. A study of double stranded DNA adsorption on aluminum surface by means of electrochemical impedance spectroscopy. Colloids Surfaces B Biointerfaces 2014;116:526–30. https://doi.org/10.1016/j.colsurfb.2014.01.046.
Whitesides GM, Grzybowski B. Self-assembly at all scales. Science (80- ) 2002;295:2418–21. https://doi.org/10.1126/science.1070821.
Martelet C, Jaffrezic-Renault N, Hou Y, Errachid A, Bessueille F. Nanostructuration and Nanoimaging of Biomolecules for Biosensors, Springer, Berlin, Heidelberg ; 2007, p. 225–57. https://doi.org/10.1007/978-3-540-37321-6_6.
Hasan A, Pandey LM. Self-assembled monolayers in biomaterials. Nanobiomaterials, Elsevier; 2018, p. 137–78. https://doi.org/10.1016/B978-0-08-100716-7.00007-6.
Ma F, Lennox RB. Potential-assisted deposition of alkanethiols on Au: Controlled preparation of single- and mixed-component SAMs. Langmuir 2000;16:6188–90. https://doi.org/10.1021/la9913046.
Fozooni T, Ravan H, Sasan H. Signal Amplification Technologies for the Detection of Nucleic Acids: from Cell-Free Analysis to Live-Cell Imaging. Appl Biochem Biotechnol 2017;183:1224–53. https://doi.org/10.1007/s12010-017-2494-4.
Fakruddin M, Mannan K Bin, Hossain M, Islam S, Mazumdar R, Chowdhury A, et al. Nucleic acid amplification: Alternative methods of polymerase chain reaction. J Pharm Bioallied Sci 2013;5:245. https://doi.org/10.4103/0975-7406.120066.
Zanoli L, Spoto G. Isothermal Amplification Methods for the Detection of Nucleic Acids in Microfluidic Devices. Biosensors 2012;3:18–43. https://doi.org/10.3390/bios3010018.
Yuan R, Ding S, Yan Y, Zhang Y, Zhang Y, Cheng W. A facile and pragmatic electrochemical biosensing strategy for ultrasensitive detection of DNA in real sample based on defective T junction induced transcription amplification. Biosens Bioelectron 2016;77:19–25. https://doi.org/10.1016/j.bios.2015.09.009.
Yan Y, Ding S, Zhao D, Yuan R, Zhang Y, Cheng W. Direct ultrasensitive electrochemical biosensing of pathogenic DNA using homogeneous target-initiated transcription amplification. Sci Rep 2016;6:18810. https://doi.org/10.1038/srep18810.
Tu Y, Ho Y, Chuang Y, Chen P, Chen C. Identification of Lactoferricin B Intracellular Targets Using an Escherichia coli Proteome Chip 2011;6. https://doi.org/10.1371/journal.pone.0028197.
Saha K, Agasti SS, Kim C, Li X, Rotello VM. Gold nanoparticles in chemical and biological sensing. Chem Rev 2012;112:2739–79. https://doi.org/10.1021/cr2001178.
Mao Y, Bao Y, Han Dx, Zhao B. Research Progress on Nitrite Electrochemical Sensor. Chinese J Anal Chem 2018;46:147–55. https://doi.org/10.1016/S1872-2040(17)61066-1.
Zhu Y, Zeng G, Zhang Y, Tang L, Chen J, Cheng M, et al. Highly sensitive electrochemical sensor using a MWCNTs/GNPs-modified electrode for lead (II) detection based on Pb 2+ -induced G-rich DNA conformation. Analyst 2014;139:5014. https://doi.org/10.1039/C4AN00874J.
Chen J, Huang Z, Luo Z, Yu Q, Xu Y, Wang X, et al. Multichannel-Structured Three-Dimensional Chip for Highly Sensitive Pathogenic Bacteria Detection Based on Fast DNA-Programmed Signal Polymerization. Anal Chem 2018;90:12019–26. https://doi.org/10.1021/acs.analchem.8b02650.
Wu P, Li S, Ye X, Ning B, Bai J, Peng Y, et al. Cu/Au/Pt trimetallic nanoparticles coated with DNA hydrogel as target-responsive and signal-amplification material for sensitive detection of microcystin-LR. Anal Chim Acta 2020;1134:96–105. https://doi.org/10.1016/j.aca.2020.08.004.
Liu Y, Ji J, Cui F, Sun J, Wu H, Pi F, et al. Development of a two-step immunochromatographic assay for microcystin-LR based on fluorescent microspheres. Food Control 2019;95:34–40. https://doi.org/10.1016/j.foodcont.2018.07.036.
Zhang W, Han C, Jia B, Saint C, Nadagouda M, Falaras P, et al. A 3D graphene-based biosensor as an early microcystin-LR screening tool in sources of drinking water supply. Electrochim Acta 2017;236:319–27. https://doi.org/10.1016/j.electacta.2017.03.161.
Arora P, Sindhu A, Dilbaghi N, Chaudhury A. Biosensors as innovative tools for the detection of food borne pathogens. Biosens Bioelectron 2011;28:1–12. https://doi.org/10.1016/j.bios.2011.06.002.
Ercole C, Del Gallo M, Mosiello L, Baccella S, Lepidi A. Escherichia coli detection in vegetable food by a potentiometric biosensor. Sensors Actuators, B Chem 2003;91:163–8. https://doi.org/10.1016/S0925-4005(03)00083-2.
Torun Ö, Hakki Boyaci I, Temür E, Tamer U. Comparison of sensing strategies in SPR biosensor for rapid and sensitive enumeration of bacteria. Biosens Bioelectron 2012;37:53–60. https://doi.org/10.1016/j.bios.2012.04.034.
Yan C, Dong F, Chun-yuan B, Si-rong Z, Jian-guo S. Recent Progress of Commercially Available Biosensors in China and Their Applications in Fermentation Processes. J Northeast Agric Univ (English Ed 2014;21:73–85. https://doi.org/10.1016/s1006-8104(15)30023-4.
Chen QH, Yang Y, He HL, Xie JF, Cai SX, Liu AR, et al. The effect of glutamine therapy on outcomes in critically ill patients: A meta-analysis of randomized controlled trials. Crit Care 2014;18:R8. https://doi.org/10.1186/cc13185.
Bäcker M, Rakowski D, Poghossian A, Biselli M, Wagner P, Schöning MJ. Chip-based amperometric enzyme sensor system for monitoring of bioprocesses by flow-injection analysis. J Biotechnol 2013;163:371–6. https://doi.org/10.1016/j.jbiotec.2012.03.014.
Ghasemi-Varnamkhasti M, Rodríguez-Méndez ML, Mohtasebi SS, Apetrei C, Lozano J, Ahmadi H, et al. Monitoring the aging of beers using a bioelectronic tongue. Food Control 2012;25:216–24. https://doi.org/10.1016/j.foodcont.2011.10.020.
Mishra RK, Dominguez RB, Bhand S, Muñoz R, Marty JL. A novel automated flow-based biosensor for the determination of organophosphate pesticides in milk. Biosens Bioelectron 2012;32:56–61. https://doi.org/10.1016/j.bios.2011.11.028.
Arduini F, Ricci F, Tuta CS, Moscone D, Amine A, Palleschi G. Detection of carbamic and organophosphorous pesticides in water samples using a cholinesterase biosensor based on Prussian Blue-modified screen-printed electrode. Anal Chim Acta 2006;580:155–62. https://doi.org/10.1016/j.aca.2006.07.052.
Suprun E, Evtugyn G, Budnikov H, Ricci F, Moscone D, Palleschi G. Acetylcholinesterase sensor based on screen-printed carbon electrode modified with prussian blue. Anal Bioanal Chem 2005;383:597–604. https://doi.org/10.1007/s00216-005-0002-0.
Ivanov A, Evtugyn G, Budnikov H, Ricci F, Moscone D, Palleschi G. Cholinesterase sensors based on screen-printed electrodes for detection of organophosphorus and carbamic pesticides. Anal Bioanal Chem 2003;377:624–31. https://doi.org/10.1007/s00216-003-2174-9.
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