Antimicrobial Resistance in the 21st CENTURY: Towards a Post-antibiotic Era?

Authors

  • Johanna Marcela Vanegas Múnera University of Antioquia
  • Judy Natalia Jiménez Quiceno University of Antioquia

DOI:

https://doi.org/10.17533/udea.rfnsp.v38n1e337759

Keywords:

post-antibiotic era, antibiotics, antibiotic resistance, epidemiology

Abstract

Alexander Fleming’s discovery of penicillin in 1928 marked the beginning of an era characterized by the development of different groups of antibiotics that allowed the proper treatment of serious infections caused by bacteria that affected the world population. However, the development of each class of antibiotics almost simultaneously triggered the emergence of resistant bacteria, due in part to the widespread and inappropriate use of these medicines. As a result, managing bacterial infections has become increasingly complicated and currently there are few treatment options, added to the fact that the development of new antimicrobials is no longer attractive to the pharmaceutical industry. This situation has led the World Health Organization to warn of the arrival of a post-antibiotic era, where common or previously easily treated infections could cause deaths as a result of bacterial resistance to several groups of antibiotics. Therefore, questions arise about how this situation could have come to be and what solutions are needed to avoid the dreaded post-antibiotic era, questions that we attempt to answer in this paper by addressing aspects related
not only to microorganisms, but also to social, economic and even political contexts, which influence the increase of antimicrobial resistance and hinder its control.
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Author Biographies

Johanna Marcela Vanegas Múnera, University of Antioquia

Microbiologist, MSc, PhD (candidate). Bacterial Molecular Epidemiology Line, Basic and Applied Microbiology Group, University of Antioquia. Medellin Colombia.

Judy Natalia Jiménez Quiceno, University of Antioquia

Bacteriologist, MSc, PhD. Bacterial Molecular Epidemiology Line, Basic and Applied Microbiology Group, University of Antioquia. Medellin, Colombia.

References

(1). Tang SS, Apisarnthanarak A, Hsu LY. Mechanisms of β-lactam antimicrobial resistance and epidemiology of major community-and healthcare-associated multidrug-resistant bacteria. Adv Drug Deliv Rev. 2014;78:3-13. doi: https://doi.org/10.1016/j. addr.2014.08.003.

(2). Laxminarayan R, Duse A, Wattal C, et al. Antibiotic resistance-the need for global solutions. Lancet Infect Dis. 2013;13(12):1057- 98. doi: https://doi.org/10.1016/S1473-3099(13)70318-9

(3). Zaffiri L, Gardner J, Toledo-Pereyra LH. History of antibiotics. From salvarsan to cephalosporins. J Invest Surg. 2012;25(2):67- 77. doi: https://doi.org/10.3109/08941939.2012.664099

(4). World Health Organization. Antibiotic resistance [internet]; 2019 [citado 2019 dic. 2]. Disponible en: https://www.who.int/ en/news-room/fact-sheets/detail/antibiotic-resistance

(5). Fair RJ, Tor Y. Antibiotics and bacterial resistance in the 21st century. Perspect Medicin Chem. 2014;6:25-64. doi: https://doi. org/10.4137/PMC.S14459

(6). Maldonado NA, Múnera MI, López JA, et al. Tendencias de la resistencia a antibióticos en Medellín y en los municipios del área metropolitana entre 2007 y 2012: resultados de seis años de vigilancia. Biomedica. 2014;34(3):433-46. doi: https://doi. org/10.7705/biomedica.v34i3.1658

(7). Vasoo S, Barreto JN, Tosh PK. Emerging issues in gram-negative bacterial resistance: An update for the practicing clinician. Mayo Clin Proc. 2015;90(3):395-403. doi: https://doi.org/10.1016/j. mayocp.2014.12.002

(8). Logan LK. Carbapenem-resistant enterobacteriaceae: An emerging problem in children. Clin Infect Dis. 2012;55(6):852- 9. doi: https://doi.org/10.1093/cid/cis543.

(9). Loho T, Dharmayanti A. Colistin: An antibiotic and its role in multiresistant Gram-negative infections. Acta Med Indones. 2015;47(2):157-68.

(10). Brandt C, Makarewicz O, Fischer T, et al. The bigger picture: The history of antibiotics and antimicrobial resistance displayed by scientometric data. Int J Antimicrob Agents. 2014;44(5):424- 30. doi: https://doi.org/10.1016/j.ijantimicag.2014.08.001

(11). Centers for Disease Control and Prevention. Biggest Threats and Data [internet]. 2019. [citado 2019 nov. 26]. Disponible en: https://www.cdc.gov/drugresistance/biggest-threats. html?CDC_AA_refVal=https%3A%2F%2Fwww.cdc. gov%2Fdrugresistance%2Fbiggest_threats.htmlhttp://www.cdc. gov/drugresistance/threat-report-2013/.

(12). O’Neill J. Antimicrobial resistance: Tackling a crisis for the health and wealth of nations. The Review on Antimicrobial Resistance. 2014.

(13). Hwang AY, Gums JG. The emergence and evolution of antimicrobial resistance: Impact on a global scale. Bioorg Med Chem. 2016;24(24):6440-5. doi: https://doi.org/10.1016/j. bmc.2016.04.027

(14). Essack SY, Sartorius B. Global antibiotic resistance: Of contagion, confounders, and the com-b model. Lancet Planet Health. 2018;2(9):e376-e7. doi: https://doi.org/10.1016/S2542- 5196(18)30187-6

(15). Quizhpe A, editor. Uso apropiado de antibióticos y resistencia bacteriana. Cuenca, Ecuador: ReAct Latinoamérica, Facultad de Ciencias Médicas, Asociación de Facultades Ecuatorianas de Ciencias Médicas y de la Salud (afeme); 2014.

(16). Walsh TR. A one-health approach to antimicrobial resistance. Nat Microbiol. 2018;3(8):854-5. doi: https://doi.org/10.1038/ s41564-018-0208-5

(17). López M, Tenorio C, Torres C. Study of vancomycin resistance in faecal enterococci from healthy humans and dogs in Spain a decade after the avoparcin ban in Europe. Zoonoses Public Health. 2013;60(2):160-7. doi: https://doi.org/10.1111/j.1863- 2378.2012.01502.x

(18). Palop Larrea V, Melchor Penella A, Martínez Mir I. Reflexiones sobre la utilización de antibióticos en atención primaria. Aten Primaria. 2003;32(1):42-47.

(19). Md Rezal RS, Hassali MA, Alrasheedy AA, et al. Physicians’ knowledge, perceptions and behaviour towards antibiotic prescribing: A systematic review of the literature. Expert Rev Anti Infect Ther. 2015;13(5):665-80. doi: https://doi.org/10.15 86/14787210.2015.1025057

(20). Churchill LR, Perry JE. The “medical-industrial complex”. J Law Med Ethics. 2014;42(4):408-11. doi: https://doi.org/10.1111/ jlme.12163

(21). Kunin CM. Evaluation of antibiotic usage: A comprehensive look at alternative approaches. Rev Infect Dis. 1981;3(4):745- 53. doi: https://doi.org/10.1093/clinids/3.4.745

(22). Neiderud CJ. How urbanization affects the epidemiology of emerging infectious diseases. Infect Ecol Epidemiol. 2015;5:27060. doi: https://doi.org/10.3402/iee.v5.27060

(23). Doi Y, Iovleva A, Bonomo RA. The ecology of extended-spectrum β-lactamases (esbls) in the developed world. J Travel Med. 2017;24(suppl_1):S44-S51. doi: https://doi.org/10.1093/ jtm/taw102

(24). Saliba V, Washer P, Pett P, et al. A comparative analysis of how the media in the United Kingdom and India represented the emergence of ndm-1. J Public Health Policy. 2016;37(1):1-19. doi: https://doi.org/10.1057/jphp.2015.30

(25). Ministerio de Salud y Protección Social. Programa de prevención, vigilancia y control de infecciones asociadas a la atención en salud-iaas y la resistencia antimicrobiana [internet]. 2018. [citado 2019 dic. 02]. Disponible en: https://www.minsalud.gov. co/sites/rid/Lists/BibliotecaDigital/RIDE/VS/PP/PAI/programa-iaas-ram.pdf

(26). Breilh J. Epidemiología: economía, política y salud. Santo Domingo: Universidad Autónoma de Santo Domingo; 2009.

(27). Comisión sobre Determinantes Sociales de la Salud, Organización Mundial de la Salud. Subsanar las desigualdades en una generación [internet]; 2009. [citado 2019 dic. 2]. Disponible en: https://www.who.int/social_determinants/thecommission/ finalreport/es/

(28). Krieger N. Proximal, distal, and the politics of causation: What’s level got to do with it? Am J Public Health. 2008;98(2):221-30. doi: https://doi.org/10.2105/AJPH.2007.111278

(29). Ramírez AI, Torres P, Fabro G, et al. Epidemias y salud pública. Buenos Aires: Ministerio de Educación de la Nación [internet]. 2013. [citado 2019 nov. 26]. Disponible en: https://www. academia.edu/31119391/Epidemias_y_salud_publica

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Published

2020-02-13

How to Cite

1.
Vanegas Múnera JM, Jiménez Quiceno JN. Antimicrobial Resistance in the 21st CENTURY: Towards a Post-antibiotic Era?. Rev. Fac. Nac. Salud Pública [Internet]. 2020 Feb. 13 [cited 2025 Dec. 6];38(1):1-6. Available from: https://revistas.udea.edu.co/index.php/fnsp/article/view/337759

Issue

Vol. 38 No. 1 (2020): Enero-Abril

Section

Servicios de salud

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Copyright (c) 2021 Johanna Marcela Vanegas Múnera, Judy Natalia Jiménez Quiceno

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