Pregabalin as a perioperative strategy for pain management in patients undergoing cosmetic surgery. A randomized, double-blind, and placebo-controlled study

  • Luis Enrique Chaparro Gómez Toronto Western Hospital
  • Paola Valdés Cuartas Universidad de Antioquia
  • Mauricio Mira Correa Universidad de Antioquia
  • Fernando Montoya Maya Universidad de Antioquia
  • Lorena Duque Universidad de Antioquia

Resumen

BACKGROUND: Preoperative Gabapentin has demonstrated to be as analgesic strategy in the control of perioperative pain. Pregabalin -an analogue of Gabapentin- has only a few trials demonstrating its effectiveness on this clinical setting. We wanted to assess the effectiveness of pregabalin given not only as a single dose in the preoperative period, but also continuing its administration 75 mg bid up to the fourth day after surgery. METHODS: Previous consent by the Ethical Committee of the University, we enrolled 110 patients undergoing ambulatory liposuction. They were randomized and blindedallocated to receive Pregabalin (75 mg bid) versus placebo, starting 12 hours before surgery up to the fourth day after surgery. We use the postoperative pain intensity by numerical rating scale, pain intensity by categorical pain scale and tramadol-ibuprofen request as primary outcomes. RESULTS: We had 9 dropouts during the recruitment and follow up. 24 hours after surgery we had 18/51 (35.3%) versus 16/50 (32%) (p=0.7). We also found no difference in opioid request at the same time point, being 6.3 mg morphine equivalents in the pregabalin versus 6.7 mg in the Placebo Group. Subsequent evaluations at 48, 72 and 96 hours demonstrated no difference between groups for analgesic request and pain intensity. CONCLUSION: Perioperative use of Pregabalin (75 mg bid) does not offer benefit as analgesic strategy in terms of pain intensity and opioid requirement in patients undergoing cosmetic liposuction.
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Biografía del autor/a

Luis Enrique Chaparro Gómez, Toronto Western Hospital
MD, Professor of Anesthesia, Universidad de Antioquia, Medellín, Colombia. Clinical Fellow. Comprehensive Pain Program. Toronto Western Hospital. Toronto, Ontario
Paola Valdés Cuartas, Universidad de Antioquia
MD, Resident of Anesthesia, School of Medicine, University of Antioquia, Medellín, Colombia.
Mauricio Mira Correa, Universidad de Antioquia
MD, Resident of Anesthesia, School of Medicine, University of Antioquia, Medellín, Colombia.
Fernando Montoya Maya, Universidad de Antioquia
MD, Epidemiologist, School of Medicine, University of Antioquia, Medellín Colombia.
Lorena Duque, Universidad de Antioquia
RN, Epidemiologist, School of Nursing, University of Antioquia, Medellín Colombia.
Publicado
2008-11-11
Cómo citar
Chaparro Gómez, L. E., Valdés Cuartas, P., Mira Correa, M., Montoya Maya, F., & Duque, L. (2008). Pregabalin as a perioperative strategy for pain management in patients undergoing cosmetic surgery. A randomized, double-blind, and placebo-controlled study. Iatreia, 21(4-S), S32-. Recuperado a partir de https://revistas.udea.edu.co/index.php/iatreia/article/view/4522
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