Los índices de masa magra total y apendicular se relacionan negativamente con la mioesteatosis y el síndrome metabólico
DOI:
https://doi.org/10.17533/udea.iatreia.350283Keywords:
Composición Corporal, Síndrome Metabólico, LípidosAbstract
La masa magra (MM) se asocia de forma inversa con la presencia de síndrome metabólico (SM) 1-3; asimismo, se ha observado que la acumulación de lípidos intramusculares (LIM), evaluados por espectroscopía por resonancia magnética nuclear (1 H-MRS), está incrementada en las personas con obesidad, resistencia a la insulina (RI) y disfunción mitocondrial muscular 4-6. Estos resultados sugieren que tener una mayor MM podría proteger contra la infiltración grasa en el músculo (mioesteatosis) y el SM. Para evaluar esto, exploramos la relación entre la MM (total y apendicular) y los LIM, medidos por 1 H-MRS, en una cohorte de adultos colombianos con factores de riesgo metabólicos.
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(1) Nomura K, Eto M, Ogawa S, et al. Association between low muscle mass and metabolic syndrome in elderly Japanese women. PloS one. 2020;15(12):e0243242. doi:10.1371/journal.pone.0243242
(2) Park BS, Yoon JS. Relative skeletal muscle mass is associated with development of metabolic syndrome. Diabetes Metab J. 2013;37(6):458-464. doi:10.4093/ dmj.2013.37.6.458
(3) Londoño FJ, Calderón JC, Gallo J. Association between thigh muscle development and the metabolic syndrome in adults. Ann Nutr Metab. 2012;61(1):41-6. doi:10.1159/000339267
(4) Savage DB, Watson L, Carr K, et al. Accumulation of saturated intramyocellular lipid is associated with insulin resistance. J Lipid Res. 2019;60(7):1323-1332. doi:10.1194/jlr.M091942
(5) Perseghin G, Scifo P, De Cobelli F, et al. Intramyocellular triglyceride content is a determinant of in vivo insulin resistance in humans: a 1H-13C nuclear magnetic resonance spectroscopy assessment in offspring of type 2 diabetic parents. Diabetes. 1999;48(8):1600- 6. doi:10.2337/diabetes.48.8.1600
(6) Petersen KF, Dufour S, Befroy D, Garcia R, Shulman GI. Impaired mitochondrial activity in the insulin-resistant offspring of patients with type 2 diabetes. N Engl J Med. 2004;350(7):664-71. doi:10.1056/NEJMoa031314.
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