SCREENING OF MARINE BACTERIAL STRAINS AS SOURCE OF QUORUM SENSING INHIBITORS (QSI): FIRST CHEMICAL STUDY OF Oceanobacillus profundus (RKHC-62B)

Authors

  • Diana Martínez-Matamoros Universidad Nacional de Colombia
  • Melissa Laiton-Fonseca Universidad Nacional de Colombia
  • Carmenza Duque Universidad Nacional de Colombia
  • Freddy A. Ramos Universidad Nacional de Colombia https://orcid.org/0000-0002-9271-7193
  • Leonardo Castellanos Universidad Nacional de Colombia

DOI:

https://doi.org/10.17533/udea.vitae.v23n1a04

Keywords:

Marine natural products, Marine microorganisms, Jeotgalicoccus halophilus, Oceanobacillus profundus, Quorum sensing inhibitor compounds.

Abstract

Background: Natural products isolated from marine microorganisms have demonstrated a wide range of biological activities included quorum sensing inhibitors. Objectives: We study fifteen marine Firmicutes bacterial strains isolated from the Caribbean soft coral Antillogorgia elisabethae that were evaluated as a novel and sustainable source of quorum sensing inhibitor compounds. Methods: Cultures were made in four different culture media and further extracted using a non-ionic resin. All these extracts were tested in order to establish its quorum sensing inhibition (QSI) activity using Chromobacterium violaceum ATCC 31532. The active extracts were fractionated by RP-18 cartridge. Each fraction was tested and evaluated for its composition by HPLC-PDA. Results: Methanol fractions of Jeotgalicoccus halophilus and Oceanobacillus profundus were the most active ones, suggesting that non-polar compounds could be the responsible for the QSI activity of the bacterial extracts here tested. Conclusions: The chemical study of the organic extract of Oceanobacillus profundus cultured in LBS, yielded the compounds tyrosol (1) and tyrosol acetate (2) as responsible of QSI activity showed by the organic extract.
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Author Biographies

Diana Martínez-Matamoros, Universidad Nacional de Colombia

Facultad de Ciencias, Departamento de Química, Laboratorio de Productos Naturales Marinos, MSc

Melissa Laiton-Fonseca, Universidad Nacional de Colombia

Facultad de Ciencias, Departamento de Química, Laboratorio de Productos Naturales Marinos, PhD

Carmenza Duque, Universidad Nacional de Colombia

Facultad de Ciencias, Departamento de Química, Laboratorio de Productos Naturales Marinos, PhD

Freddy A. Ramos, Universidad Nacional de Colombia

Facultad de Ciencias, Departamento de Química, Laboratorio de Productos Naturales Marinos, PhD

Leonardo Castellanos, Universidad Nacional de Colombia

Facultad de Ciencias, Departamento de Química, Laboratorio de Productos Naturales Marinos, PhD

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Published

02-07-2016

How to Cite

Martínez-Matamoros, D., Laiton-Fonseca, M., Duque, C., Ramos, F. A., & Castellanos, L. (2016). SCREENING OF MARINE BACTERIAL STRAINS AS SOURCE OF QUORUM SENSING INHIBITORS (QSI): FIRST CHEMICAL STUDY OF Oceanobacillus profundus (RKHC-62B). Vitae, 23(1), 30–47. https://doi.org/10.17533/udea.vitae.v23n1a04

Issue

Section

Natural Products