Effect of Lepidium meyenii (maca) on spatial memory and brain oxidative damage of ovariectomized-rats exposed to mobile phone

Authors

DOI:

https://doi.org/10.17533/udea.vitae.v28n1a342472

Keywords:

Ovariectomy, Estrogens, Nutrition, Cognition, Malondialdehyde, Lepidium meyenii (maca), Spatial memory, Brain oxidative damage

Abstract

Background: Oxidative stress, genetic expression changes, and decomposition of the blood-brain barrier have been shown to be caused by exposure to radiofrequency radiation (RFR); therefore, the search for drugs or food products that offer some protection from these effects has attracted interest. Lepidium meyenii (maca) is a native Andean plant known for its effects on the female reproductive system as well as its immunomodulating, energizing, antioxidant, and nutritive properties due to its high concentration of alkaloids, amino acids, glucosinolates, fatty acids, and macamides. Objectives: We aim to determine the effect of dietary maca supplementation on spatial memory and cerebral oxidative damage in rats with induced menopause and/or with exposure to mobile phone radiation. Method: Female rats divided into 6 groups (six rats in each group): control or not ovariectomized (O-), ovariectomized (O+), ovariectomized + estrogen (O+E+), ovariectomized + estrogen + irradiated (O+E+I+), ovariectomized + maca (O+M+), and ovariectomized + maca + irradiated (O+M+I). Rat spatial memory was tested using the Morris water navigation task. Rats were sacrificed, and cerebral malondialdehyde was measured. Results: After exposure to mobile phone radiation, the group supplemented with maca showed improved spatial memory and lower levels of malondialdehyde than the estrogenized group. Conclusions: Our results suggest that consumption of maca has a positive effect on the maintenance of memory and decreases oxidative stress caused by mobile phone radiation. However, it is necessary to extend this work using a larger sample size.

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Author Biographies

Carmen Marín-Tello, Universidad Privada Antenor Orrego

Professor of Veterinary Pharmacology and Therapeutics at the School of Veterinary Medicine and Zootechnics.

Haydée Villafana-Medina, Universidad Nacional de Trujillo

Professor of the Chair of Healthcare Pharmacy. Faculty of Pharmacy and Biochemistry

José Aliaga-Arauco, Universidad Peruana Cayetano Heredia

Professor in the Department of Cellular and Molecular Sciences. Pharmaceutical Sciences Section.

Violeta Malpartida-Tello, Universidad Santo Toribio de Mogrovejo

Professor of Sociology and Social Reality. Humanities DepartmentSocial Researcher of the Laboratory for Research in Physiology and Physiopathology of Food Metabolism in the Route of Nutritional Research. Faculty of Pharmacy and Biochemistry of the National University of Trujillo.

 

 

Elio Castañeda-Marín, Universidad Privada Antenor Orrego

Past President Scientific Society of Medical Students UPAO

César Sánchez-Marín, Universidad Nacional de Trujillo.

Medical researcher. Research Laboratory in Physiology and Physiopathology of Food Metabolism in the Route of Nutritional Research. Department of Pharmacology. Faculty of Pharmacy and Biochemistry.

Jorge Vásquez-Kool, Meredith College: Raleigh, NC, US

Associate Professor (Biological Sciences)
Genetics, Molecular Biology, Microbiology, Biotechnology

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Published

25-01-2021

How to Cite

Marín-Tello, C., Villafana-Medina, H., Aliaga-Arauco, J., Malpartida-Tello, V., Castañeda-Marín, E., Sánchez-Marín, C., & Vásquez-Kool, J. (2021). Effect of Lepidium meyenii (maca) on spatial memory and brain oxidative damage of ovariectomized-rats exposed to mobile phone. Vitae, 28(01). https://doi.org/10.17533/udea.vitae.v28n1a342472

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Natural Products

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