Effect of Lepidium meyenii (maca) on spatial memory and brain oxidative damage of ovariectomized-rats exposed to mobile phone





Ovariectomy, Estrogens, Nutrition, Cognition, Malondialdehyde, Lepidium meyenii (maca), Spatial memory, Brain oxidative damage


Background: Oxidative stress, genetic expression changes, and decomposition of the blood-brain barrier have been shown to be caused by exposure to radiofrequency radiation (RFR); therefore, the search for drugs or food products that offer some protection from these effects has attracted interest. Lepidium meyenii (maca) is a native Andean plant known for its effects on the female reproductive system as well as its immunomodulating, energizing, antioxidant, and nutritive properties due to its high concentration of alkaloids, amino acids, glucosinolates, fatty acids, and macamides. Objectives: We aim to determine the effect of dietary maca supplementation on spatial memory and cerebral oxidative damage in rats with induced menopause and/or with exposure to mobile phone radiation. Method: Female rats divided into 6 groups (six rats in each group): control or not ovariectomized (O-), ovariectomized (O+), ovariectomized + estrogen (O+E+), ovariectomized + estrogen + irradiated (O+E+I+), ovariectomized + maca (O+M+), and ovariectomized + maca + irradiated (O+M+I). Rat spatial memory was tested using the Morris water navigation task. Rats were sacrificed, and cerebral malondialdehyde was measured. Results: After exposure to mobile phone radiation, the group supplemented with maca showed improved spatial memory and lower levels of malondialdehyde than the estrogenized group. Conclusions: Our results suggest that consumption of maca has a positive effect on the maintenance of memory and decreases oxidative stress caused by mobile phone radiation. However, it is necessary to extend this work using a larger sample size.

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Author Biographies

Carmen Marín-Tello, Universidad Privada Antenor Orrego

Professor of Veterinary Pharmacology and Therapeutics at the School of Veterinary Medicine and Zootechnics.

Haydée Villafana-Medina, Universidad Nacional de Trujillo

Professor of the Chair of Healthcare Pharmacy. Faculty of Pharmacy and Biochemistry

José Aliaga-Arauco, Universidad Peruana Cayetano Heredia

Professor in the Department of Cellular and Molecular Sciences. Pharmaceutical Sciences Section.

Violeta Malpartida-Tello, Universidad Santo Toribio de Mogrovejo

Professor of Sociology and Social Reality. Humanities DepartmentSocial Researcher of the Laboratory for Research in Physiology and Physiopathology of Food Metabolism in the Route of Nutritional Research. Faculty of Pharmacy and Biochemistry of the National University of Trujillo.



Elio Castañeda-Marín, Universidad Privada Antenor Orrego

Past President Scientific Society of Medical Students UPAO

César Sánchez-Marín, Universidad Nacional de Trujillo.

Medical researcher. Research Laboratory in Physiology and Physiopathology of Food Metabolism in the Route of Nutritional Research. Department of Pharmacology. Faculty of Pharmacy and Biochemistry.

Jorge Vásquez-Kool, Meredith College: Raleigh, NC, US

Associate Professor (Biological Sciences)
Genetics, Molecular Biology, Microbiology, Biotechnology


Signorelli SS, Neri S, Sciacchitano S, Di Pino L, Costa MP, Marchese G, et al. Behaviour of some indicators of oxidative stress in postmenopausal and fertile women. Maturitas. 2006;53(1):77–82. https://doi.org/10.1016/j.maturitas.2005.03.001

Sliwinski JR, Johnson AK, Elkins GR. Memory decline in peri- and post-menopausal women: The potential of mind-body medicine to improve cognitive performance. Integr Med Insights. 2014;(9):17–23. https://doi.org/10.4137/IMI.S15682}

Frick KM. Molecular mechanisms underlying the memory-enhancing effects of estradiol. Horm Behav [Internet]. 2015;74:4–18. Available from: http://dx.doi.org/10.1016/j.yhbeh.2015.05.001

Weiss G, Skurnick JH, Goldsmith LT, Santoro NF, Park SJ. Menopause and hypothalamic-pituitary sensitivity to estrogen. J Am Med Assoc. 2004;292(24):2991–6. https://doi.org/10.1001/jama.292.24.2991

Atwood CS, Bowen RL. The endocrine dyscrasia that accompanies menopause and andropause induces aberrant cell cycle signaling that triggers re-entry of post-mitotic neurons into the cell cycle, neurodysfunction , neurodegeneration and cognitive disease. Horm Behav. 2015;76:63–80. http://dx.doi.org/10.1016/j.yhbeh.2015.06.021

Rao AK, Dietrich AK, Ziegler YS, Nardulli AM. 17 β-Estradiol-mediated increase in Cu / Zn superoxide dismutase expression in the brain: A mechanism to protect neurons from ischemia. J Steroid Biochem Mol Biol [Internet]. 2011;127(3–5):382–9. http://dx.doi.org/10.1016/j.jsbmb.2011.06.008

Kim H-G, Jang S-S, Lee J-S, Kim H-S, Son C-G. Panax ginseng Meyer prevents radiation-induced liver injury via modulation of oxidative stress and apoptosis. J Ginseng Res. 2017;41(2):159–68. https://doi.org/10.1016/j.jgr.2016.02.006

Kahya MC. Oxidative stress of brain and liver is increased by Wi-Fi ( 2 . 45 GHz) exposure of rats during pregnancy and the development of newborns. 2016;75:134–9. https://doi.org/10.1016/j.jchemneu.2015.10.005

Mora H ÁC, Aragón N DM, Ospina G LF. Caracterización del estrés oxidativo en ratas Wistar diabéticas por estreptozotocina. Vitae. 2009;16(3):311–9 http://www.scielo.org.co/scielo.php?script=sci_arttext&pid=S0121-40042009000300005&lng=en

Gonzales GF, Villaorduña L, Gasco M, Rubio J, Gonzales C. [Maca (Lepidium meyenii Walp), a review of its biological properties]. Rev Peru Med Exp Salud Publica. 2014;31(1):100–10. http://www.ncbi.nlm.nih.gov/pubmed/24718534

Zha S, Zhao Q, Chen J, Wang L, Zhang G, Zhang H, et al. Extraction, purification and antioxidant activities of the polysaccharides from maca (Lepidium meyenii). Carbohydr Polym. 2014;111:584–587. http://dx.doi.org/10.1016/j.carbpol.2014.05.017

McCollom MM, Villinski JR, McPhail KL, Craker LE, Gafner S. Analysis of macamides in samples of Maca (Lepidium meyenii) by HPLC-UV-MS/MS. Phytochem Anal. 2005;16(6):463–469. http://www.ncbi.nlm.nih.gov/pubmed/16315492

Cruz VM. Riesgo para la salud por radiaciones no ionizantes de las redes de energía eléctrica en el Perú. Rev Peru Med Exp Salud Publica . 2009;26(1):104–112. http://www.scielo.org.pe/pdf/rins/v26n1/a18v26n1.pdf

Prins J-B, Smith D, Degryse A-D. Chapter 5 – The European Framework on Research Animal Welfare Regulations and Guidelines. In: Laboratory Animals. 2014. p. 117–88. Available from: http://www.sciencedirect.com.scopeesprx.elsevier.com/science/article/pii/B9780123978561000052

Khajuria DK, Razdan R, Mahapatra DR. Description of a new method of ovariectomy in female rats. Rev Bras Reumatol. 2012;52(3):462–470. http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0482-50042012000300016&lng=en. https://doi.org/10.1590/S0482-50042012000300016

Nunez J. Morris water maze experiment. J Vis Exp. 2008;(19):12–13. https://doi.org/10.3791/897

Morote Guzmán JI, Yaro Marcelo RD. Efecto de lepidium meyenii walp (maca) ecotipo roja en la lipoperoxidación inducida en membranas neuronales de rattus rattus variedad albinus ooforectomizadas. Universidad Nacional de Trujillo. 2012. http://dspace.unitru.edu.pe/handle/UNITRU/3975

Vorhees C V, Williams MT. Assessing spatial learning and memory in rodents. ILAR J. 2014;55(2):310–332. http://www.ncbi.nlm.nih.gov/pubmed/25225309

Pretel OS. Efecto protector y antioxidante de Psidium guajaba “guayaba” sobre la ulcera gastrica inducida por Acido acetil salicilico “aspirina” en Rattus rattus var. albinus. Universidad Nacional de Trujillo; 2012. http://dspace.unitru.edu.pe/bitstream/handle/UNITRU/2299/Periche

Enriquez Cruzalegui V, Gerónimo Yengle D. Efecto del extracto crudo de physalis peruviana sobre memoria espacial y niveles de malondialdehido en membranas neuronales de rattus norvegicus var. albinus ooforectomizadas.”. Univ Nac Trujillo. 2014; http://dspace.unitru.edu.pe/handle/UNITRU/3708

Stojanovska L, Law C, Lai B, Chung T, Nelson K, Day S, et al. Maca reduces blood pressure and depression, in a pilot study in postmenopausal women. Climacteric. 2015;18(1):69–78. http://www.tandfonline.com/doi/full/10.3109/13697137.2014.929649

Solis-Gaspar C, Vazquez-Roque RA, De Jesús Gómez-Villalobos M, Flores G. Cerebrolysin improves memory and ameliorates neuronal atrophy in spontaneously hypertensive, aged rats. Synapse 2016;70(9):378–89. http://doi.wiley.com/10.1002/syn.21912

Liu J, Head E, Gharib AM, Yuan W, Ingersoll RT, Hagen TM, et al. Memory loss in old rats is associated with brain mitochondrial decay and RNA/DNA oxidation: partial reversal by feeding acetyl-L-carnitine and/or R-alpha -lipoic acid. Proc Natl Acad Sci U S A. 2002;99(4):2356–2361. http://www.ncbi.nlm.nih.gov/pubmed/11854529

Park M, Kim CH, Jo S, Kim E, Rhim H, Lee C et al. Chronic Stress Alters Spatial Representation and Bursting Patterns of Place Cells in Behaving Mice. Sci Rep. 2015:16235. https://doi.org/10.1038/srep16235

Willis T, Muessig L, Cacucci F. The development of spatial behaviour and the hippocampal neural representation of space. Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2013;369(1635),20130409. https://doi.org/10.1098/rstb.2013.0409

Palmos AB, Duarte RRR, Smeeth DM, Hedges E, Nixon D, Thuret S et al. Telomere length and human hippocampal neurogenesis. Neuropsychopharmacol. 2020;45, 2239–2247. https://doi.org/10.1038/s41386-020-00863-w

Ramírez-Rodríguez G, Vega-Rivera NM, Benítez-King G, Castro-García M, Ortíz-López L. Melatonin supplementation delays the decline of adult hippocampal neurogenesis during normal aging of mice. Neurosci Lett 2012;530(1):53–8. http://www.ncbi.nlm.nih.gov/pubmed/23043890

Gasco M, Villegas L, Yucra S, Rubio J, Gonzales GF. Dose–response effect of Red Maca (Lepidium meyenii) on benign prostatic hyperplasia induced by testosterone enanthate. Phytomedicine 2007;14(7–8):460–464. http://linkinghub.elsevier.com/retrieve/pii/S0944711306002182

Ko SH, Kim HS. Menopause-associated lipid metabolic disorders and foods beneficial for postmenopausal women. Nutrients. 2020;12(1). https://doi.org/10.3390/nu12010202

Dhanjal DS, , Sonali Bhardwaj, Ruchi Sharma KB 3, 2 DK, , Chirag Chopra 1, Eugenie Nepovimova 4, Reena Singh 1 and Kamil Kuca 4. Plant Fortification of the Diet for Anti-Ageing E ff ects : Nutr Rev. 2020;12(2008):1–23. https://doi.org/10.3390/nu12103008

Yábar Villanueva E. La maca (Lepidium meyenii Walp Pers) Alimento funcional andino: Bioaactivos, bioquímica y actividad biológica. Rev Investig Altoandinas - J High Andean Res. 2019;21(2):139–52. http://dx.doi.org/10.18271/ria.2019.457

Meral I, Mert H, Mert N, Deger Y, Yoruk I, Yetkin A, et al. Effects of 900-MHz electromagnetic field emitted from cellular phone on brain oxidative stress and some vitamin levels of guinea pigs. Brain Res 2007;1169:120–4. http://www.ncbi.nlm.nih.gov/pubmed/17674954

Piacente S, Carbone V, Plaza A, Zampelli A, Pizza C. Investigation of the tuber constituents of maca (Lepidium meyenii Walp.). J Agric Food Chem 2002;50(20):5621–5. http://www.ncbi.nlm.nih.gov/pubmed/12236688

Li J, Chen L, Li J, Duan Z, Zhu S, Fan L. The Composition Analysis of Maca (Lepidium meyenii Walp.) from Xinjiang and Its Antifatigue Activity. J Food Qual. 2017;2017. https://doi.org/10.1155/2017/2904951

Lee YK, Chang YH. Physicochemical and antioxidant properties of methanol extract from Maca (Lepidium meyenii walp.) leaves and roots. Food Sci Technol. 2019;39(June):278–286. http://dx.doi.org/10.1590/fst.03818




How to Cite

Marín-Tello, C., Villafana-Medina, H., Aliaga-Arauco, J., Malpartida-Tello, V., Castañeda-Marín, E., Sánchez-Marín, C., & Vásquez-Kool, J. (2021). Effect of Lepidium meyenii (maca) on spatial memory and brain oxidative damage of ovariectomized-rats exposed to mobile phone. Vitae, 28(01). https://doi.org/10.17533/udea.vitae.v28n1a342472



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