Estudio comparativo de bioequivalencia de ocho preparados comerciales de Captropil
DOI:
https://doi.org/10.17533/udea.vitae.374Abstract
Se describe la evaluación biofarmacéutica de tabletas de 25 mg de captropil, midiendo la concentración plasmática con respecto al tiempo, de ocho de las marcas comerciales. Utilizamos un diseño factorial de bloques balanceados incompleto (DDBI), a doble ciego-cruzado. La variable independiente corresponde a los ocho medicamentos comerciales de captropil y la variable dependiente -el efecto medido- es la concentración plasmática de captropil. Los resultdos obtenidos mostraron que: 1.Hay equivalencia quimica entre los ocho productos ensayados. 2.Todos alcanzan los niveles de concentración plasmática en el tiempo y en la magnitud que se espera, en los esquemas de tratamiento. 3.Es posible utilizar con seguridad para tratamientos con captropil, medicamentos con nombre genérico, que sin lugar a duda, disminuye considerablemente el costo de la terapia.Downloads
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