Aproximación histórica al sistema de Neuronas Espejo

Autores/as

DOI:

https://doi.org/10.17533/udea.iatreia.291

Palabras clave:

Empatía, Historia, Neurociencias, Neuronas Espejo

Resumen

Introducción: tres décadas después del descubrimiento de las neuronas espejo (NE) se mantiene el interés por comprender su funcionamiento como sistema y se consolida su impacto en la neurociencia, la biología, la medicina y la psicología. Los avances en la investigación del mecanismo del espejo han permitido nuevas formas de pensar en cómo se generan acciones propias y se interpretan las de otras personas.
Objetivos: revisar los antecedentes históricos del sistema de NE desde su descubrimiento hasta la actualidad.
Métodos: se realizó una revisión de literatura científica publicada en bases de datos, a partir del descubrimiento de las NE en 1992 hasta 2023.
Resultados: los hallazgos de las funciones de las NE han permitido comprender tanto aspectos positivos de las relaciones humanas y no humanas como algunas alteraciones de salud mental.
Conclusiones: investigaciones en este campo podrían ser prometedoras para el desarrollo de conductas prosociales que promuevan la convivencia saludable en diferentes escenarios. El entusiasmo inicial que se manifestó con el hallazgo de las NE se ha venido matizando progresivamente dando lugar a una perspectiva funcional, neurocientífica, que requiere de mayor evidencia sobre su utilidad terapéutica y su aplicabilidad en áreas del conocimiento diferentes a las ciencias de la salud.

|Resumen
= 129 veces | PDF
= 18 veces|

Descargas

Los datos de descargas todavía no están disponibles.

Biografía del autor/a

Leonardo Palacios-Sánchez, Universidad del Rosario, Bogotá, Colombia

Profesor titular de Neurología, integrante del Centro de Investigación Neurovitae y del Grupo de Investigación en Neurociencias (NeURos), Universidad del Rosario, Bogotá, Colombia.

Inés Botía, Universidad del Rosario, Bogotá, Colombia

Psicóloga, Universidad del Rosario, Bogotá, Colombia.

Ximena Palacios-Espinosa, Universidad del Rosario, Bogotá, Colombia

Profesora titular programa de Psicología, Grupo de investigación Individuo, Familia y Sociedad (IFS), Universidad del Rosario, Bogotá, Colombia.

Citas

(1) di Pellegrino G, Fadiga L, Fogassi L, Gallese V, Rizzolatti G. Understanding motor events: a neurophysiological study. Exp Brain Res [Internet]. 1992;91(1):176-80. https://doi.org/10.1007/BF00230027

(2) Gallese V, Fadiga L, Fogassi L, Rizzolatti G. Action recognition in the premotor cortex. Brain J Neurol [Internet]. 1996;119(2):593-609. https://doi.org/10.1093/brain/119.2.593

(3) Prather JF, Peters S, Nowicki S, Mooney R. Precise auditory-vocal mirroring in neurons for learned vocal communication. Nat Lond [Internet]. 2008;451(7176):305-10. https://doi.org/10.1038/nature06492

(4) Bonini L, Rotunno C, Arcuri E, Gallese V. Mirror neurons 30 years later: implications and applications. Trends Cogn Sci [Internet]. 2022;26(9):767-81. https://doi.org/10.1016/j.tics.2022.06.003

(5) Rizzolatti G, Sinigaglia C. The mirror mechanism: a basic principle of brain function. Nat Rev Neurosci [Internet]. 2016;17(12):757-65. https://doi.org/10.1038/nrn.2016.135

(6) Ramachandran V. Mirror Neurons and Imitation Learning as the Driving Force Behind the Great Leap Forward in Human Evolution [Internet]. 2000 [cited 2023 Mar 5]. Available from: https://www.edge.org/conversation/vilayanur_ramachandran-mirror-neurons-and-imitation-learning-as-the-driving-force

(7) Rizzolatti G, Fabbri-Destro M, Cattaneo L. Mirror neurons and their clinical relevance. Nat Clin Pract Neurol [Internet]. 2009;5(1):24-34. https://doi.org/10.1038/ncpneuro0990

(8) Kilner JM, Lemon RN. What We Know Currently about Mirror Neurons. Curr Biol [Internet]. 2013;23(23):R1057-62. https://doi.org/10.1016/j.cub.2013.10.051

(9) Meltzoff AN, Murray L, Simpson E, Heimann M, Nagy E, Nadel J, et al. Re-examination of Oostenbroek et al. (2016): evidence for neonatal imitation of tongue protrusion. Dev Sci [Internet]. 2018 [cited 2023 Mar 5];21(4):e12609. https://doi.org/10.1111/desc.12609

(10) Craighero L, Ghirardi V, Lunghi M, Panin F, Simion F. Two-day-old newborns learn to discriminate accelerated-decelerated biological kinematics from constant velocity motion. Cognition [Internet]. 2020;195:104126. https://doi.org/10.1016/j.cognition.2019.104126

(11) Ferrari GA, Nicolini Y, Demuru E, Tosato C, Hussain M, Scesa E, et al. Ultrasonographic Investigation of Human Fetus Responses to Maternal Communicative and Non-communicative Stimuli. Front Psychol [Internet]. 2016;7:354. https://doi.org/10.3389/fpsyg.2016.00354

(12) Yoshida K, Go Y, Kushima I, Toyoda A, Fujiyama A, Imai H, et al. Single-neuron and genetic correlates of autistic behavior in macaque. Sci Adv [Internet]. 2016;2(9):e1600558. https://doi.org/10.1126/sciadv.1600558

(13) Mazurek KA, Rouse AG, Schieber MH. Mirror Neuron Populations Represent Sequences of Behavioral Epochs During Both Execution and Observation. J Neurosci Off J Soc Neurosci [Internet]. 2018;38(18):4441-55. https://doi.org/10.1523/JNEUROSCI.3481-17.2018

(14) Papadourakis V, Raos V. Neurons in the Macaque Dorsal Premotor Cortex Respond to Execution and Observation of Actions. Cereb Cortex [Internet]. 2019;29(10):4223-37. https://doi.org/10.1093/cercor/bhy304

(15) Lanzilotto M, Ferroni CG, Livi A, Gerbella M, Maranesi M, Borra E, et al. Anterior Intraparietal Area: A Hub in the Observed Manipulative Action Network. Cereb Cortex [Internet]. 2019;29(4):1816-33. https://doi.org/10.1093/cercor/bhz011

(16) Livneh U, Resnik J, Shohat Y, Paz R. Self-monitoring of social facial expressions in the primate amygdala and cingulate cortex. Proc Natl Acad Sci [Internet]. 2012;109(46):18956-61. https://doi.org/10.1073/pnas.1207662109

(17) Bonini L. The Extended Mirror Neuron Network: Anatomy, Origin, and Functions. Neuroscientist [Internet]. 2017;23(1):56-67. https://doi.org/10.1177/1073858415626400

(18) Albertini D, Gerbella M, Lanzilotto M, Livi A, Maranesi M, Ferroni CG, et al. Connectional gradients underlie functional transitions in monkey pre-supplementary motor area. Prog Neurobiol [Internet]. 2020 [cited 2023 Mar 5];184(101699). https://doi.org/10.1016/j.pneurobio.2019.101699

(19) Peyron R, Laurent B, García-Larrea L. Functional imaging of brain responses to pain. A review and meta-analysis (2000). Neurophysiol Clin Neurophysiol [Internet]. 2000;30(5):263-88. https://doi.org/10.1016/S0987-7053(00)00227-6

(20) Kraskov A, Dancause N, Quallo MM, Shepherd S, Lemon RN. Corticospinal neurons in macaque ventral premotor cortex with mirror properties: a potential mechanism for action suppression? Neuron [Internet]. 2009;64(6):922-30. https://doi.org/10.1016/j.neuron.2009.12.010

(21) Caggiano V, Fogassi L, Rizzolatti G, Casile A, Giese MA, Thier P. Mirror neurons encode the subjective value of an observed action. Proc Natl Acad Sci [Internet]. 2012;109(29):11848-53. https://doi.org/10.1073/pnas.1205553109

(22) Carrillo M, Han Y, Migliorati F, Liu M, Gazzola V, Keysers C. Emotional Mirror Neurons in the Rat's Anterior Cingulate Cortex. Curr Biol [Internet]. 2019;29(8):1301-1312.e6. https://doi.org/10.1016/j.cub.2019.03.024

(23) Viaro R, Maggiolini E, Farina E, Canto R, Iriki A, D'Ausilio A, et al. Neurons of rat motor cortex become active during both grasping execution and grasping observation. Curr Biol [Internet]. 2021;31(19):4405-4412.e4. https://doi.org/10.1016/j.cub.2021.07.054

(24) Basile BM, Schafroth JL, Karaskiewicz CL, Chang SWC, Murray EA. The anterior cingulate cortex is necessary for forming prosocial preferences from vicarious reinforcement in monkeys. PLoS Biol [Internet]. 2020;18(6):e3000677. https://doi.org/10.1371/journal.pbio.3000677

(25) American Psychiatric Association. DSM-5. Manual diagnóstico y estadístico de los trastornos mentales [Internet]. 5a ed. Editorial Médica Panamericana; 2014. Available from: https://bit.ly/3V2CNjE

(26) Avikainen S, Wohlschläger A, Liuhanen S, Hänninen R, Hari R. Impaired mirror-image imitation in Asperger and high-functioning autistic subjects. Curr Biol [Internet]. 2003;13(4):339-41. https://doi.org/10.1016/S0960-9822(03)00087-3

(27) Nishitani N, Avikainen S, Hari R. Abnormal imitation-related cortical activation sequences in Asperger's syndrome. Ann Neurol [Internet]. 2004;55(4):558-62. https://doi.org/10.1002/ana.20031

(28) Dapretto M, Davies MS, Pfeifer JH, Scott AA, Sigman M, Bookheimer SY, et al. Understanding emotions in others: mirror neuron dysfunction in children with autism spectrum disorders. Nat Neurosci [Internet]. 2006;9(1):28-30. https://doi.org/10.1038/nn1611

(29) Ozonoff S, Pennington BF, Rogers SJ. Executive Function Deficits in High-Functioning Autistic Individuals: Relationship to Theory of Mind. J Child Psychol Psychiatry [Internet]. 1991;32(7):1081-105. https://doi.org/10.1111/j.1469-7610.1991.tb00351.x

(30) Pennington BF, Ozonoff S. Executive Functions and Developmental Psychopathology. J Child Psychol Psychiatry [Internet]. 1996;37(1):51-87. https://doi.org/10.1111/j.1469-7610.1996.tb01380.x

(31) Williams JHG, Whiten A, Suddendorf T, Perrett DI. Imitation, mirror neurons and autism. Neurosci Biobehav Rev [Internet]. 2001;25(4):287-95. https://doi.org/10.1016/S0149-7634(01)00014-8

(32) Heyes C, Catmur C. What Happened to Mirror Neurons? Perspect Psychol Sci [Internet]. 2022;17(1):153-68. https://doi.org/10.1177/1745691621990638

(33) Lanzoni S. Empathic Brains. En: Empathy: A history. Yale University Press; 2018. p. 251-76. https://doi.org/10.12987/9780300240924-012

(34) Iacoboni M. Imitation, empathy, and mirror neurons. Annu Rev Psychol [Internet]. 2009;60:653-70. https://doi.org/10.1146/annurev.psych.60.110707.163604

(35) Gallese V. The 'shared manifold' hypothesis: From mirror neurons to empathy. J Conscious Stud [Internet]. 2001;8(5-7):33-50. Available from: https://philpapers.org/rec/GALTSM

(36) Braten S. On Being Moved. From mirror neurons to empathy [Internet]. John Benjamins Publishing Company; [cited 2023 Mar 5]. Disponible en: https://benjamins.com/catalog/aicr.68

(37) Wicker B, Keysers C, Plailly J, Royet JP, Gallese V, Rizzolatti G. Both of Us Disgusted in My Insula. Neuron [Internet]. 2003;40(3):655-64. https://doi.org/10.1016/S0896-6273(03)00679-2

(38) Cook R, Bird G, Catmur C, Press C, Heyes C. Mirror neurons: From origin to function. Behav Brain Sci [Internet]. 2014;37(2):177-92. https://doi.org/10.1017/S0140525X13000903

(39) Lieberman MD. Social Cognitive Neuroscience: A Review of Core Processes. Annu Rev Psychol [Internet]. 2007;58(1):259-89. https://doi.org/10.1146/annurev.psych.58.110405.085654

(40) Hasson U, Ghazanfar AA, Galantucci B, Garrod S, Keysers C. Brain-to-brain coupling: a mechanism for creating and sharing a social world. Trends Cogn Sci [Internet]. 2012;16(2):114-21. https://doi.org/10.1016/j.tics.2011.12.007

(41) Rizzolatti G, Fabbri-Destro M. The mirror system and its role in social cognition. Curr Opin Neurobiol [Internet]. 2008;18(2):179-84. https://doi.org/10.1016/j.conb.2008.08.001

(42) Ferguson HJ, Wimmer L. A Psychological exploration of empathy. En: Mezzenzana F, Peluso D, editors. Conversations on Empathy: Interdisciplinary Perspectives on Empathy, Imagination and Othering [Internet]. Routledge; 2023. p. 60-77. Available from: https://bit.ly/3WPdfrc

(43) Corradini A, Antonietti A. Mirror neurons and their function in cognitively understood empathy. Conscious Cogn [Internet]. 2013;22(3):1152-61. https://doi.org/10.1016/j.concog.2013.03.003

(44) Hutchison WD, Davis KD, Lozano AM, Tasker RR, Dostrovsky JO. Pain-related neurons in the human cingulate cortex. Nat Neurosci [Internet]. 1999;2(5):403-5. https://doi.org/10.1038/8065

(45) Wu WY, Cheng Y, Liang KC, Lee RX, Yen CT. Affective mirror and anti-mirror neurons relate to prosocial help in rats. iScience [Internet]. 2023;26(1):105865. https://doi.org/10.1016/j.isci.2022.105865

(46) Hollan D. Emerging Issues in the Cross-Cultural Study of Empathy. Emot Rev [Internet]. 2012;4(1):70-8. https://doi.org/10.1177/1754073911421376

(47) Weisz E, Zaki J. Motivated empathy: a social neuroscience perspective. Curr Opin Psychol [Internet]. 2018;24:67-71. https://doi.org/10.1016/j.copsyc.2018.05.005

(48) Häusser LF. Empathie und Spiegelneurone. Ein Blick auf die gegenwärtige neuropsychologische Empathieforschung. Prax Kinderpsychol Kinderpsychiatr [Internet]. 2012;61(5):322-35. https://doi.org/10.13109/prkk.2012.61.5.322

(49) Stupiggia M. From Hopeless Solitude to the Sense of Being-With: Functions and Dysfunctions of Mirror Neurons in Post Traumatic Syndromes. Int Body Psychother J Art Sci Somat Prax [Internet]. 2012;11(1):25-40. Available from: https://www.ibpj.org/issues/articles/Stupiggia%20-%20From%20Hopeless%20Solitude.pdf

(50) Disner SG, Marquardt CA, Mueller BA, Burton PC, Sponheim SR. Spontaneous neural activity differences in posttraumatic stress disorder: A quantitative resting‐state meta‐analysis and fMRI validation. Hum Brain Mapp [Internet]. 2018;39(2):837-50. https://doi.org/10.1002/hbm.23886

(51) Lahuerta-Martín S, Llamas-Ramos R, Llamas-Ramos I. Effectiveness of Therapies Based on Mirror Neuron System to Treat Gait in Patients with Parkinson's Disease-A Systematic Review. J Clin Med [Internet]. 2022;11(14):4236. https://doi.org/10.3390/jcm11144236

(52) Tofani M, Santecchia L, Conte A, Berardi A, Galeoto G, Sogos C, et al. Effects of Mirror Neurons-Based Rehabilitation Techniques in Hand Injuries: A Systematic Review and Meta-Analysis. Int J Environ Res Public Health [Internet]. 2022;19(9):5526. https://doi.org/10.3390/ijerph19095526

(53) Abdullahi A, Wong TWL, Ng SSM. Rehabilitation of Severe Impairment in Motor Function after Stroke: Suggestions for Harnessing the Potentials of Mirror Neurons and the Mentalizing Systems to Stimulate Recovery. Brain Sci [Internet]. 2022;12(10):1311. https://doi.org/10.3390/brainsci12101311

(54) Mao H, Li Y, Tang L, Chen Y, Ni J, Liu L, et al. Effects of mirror neuron system‐based training on rehabilitation of stroke patients. Brain Behav [Internet]. 2020;10(8):e01729. https://doi.org/10.1002/brb3.1729

(55) Cammisuli DM, Castelnuovo G. Neuroscience-based psychotherapy: A position paper. Front Psychol [Internet]. 2023;14:1101044. https://doi.org/10.3389/fpsyg.2023.1101044

Descargas

Publicado

08-08-2024

Cómo citar

1.
Palacios-Sánchez L, Botía I, Palacios-Espinosa X. Aproximación histórica al sistema de Neuronas Espejo. Iatreia [Internet]. 8 de agosto de 2024 [citado 22 de enero de 2025];38(1). Disponible en: https://revistas.udea.edu.co/index.php/iatreia/article/view/353405

Número

Sección

Historia de la medicina

Artículos más leídos del mismo autor/a