Evaluación de los cambios morfológicos y funcionales de células del trofoblasto y mediadores fisiológicos asociados con la infección por Plasmodium falciparum
DOI:
https://doi.org/10.17533/udea.iatreia.350277Keywords:
Malaria in pregnancy, Placenta, P. falciparum, Trophoblast, Diagnostic markers, Dysfunction markersAbstract
La infección por Plasmodium falciparum en el embarazo genera alrededor de 150.000 muertes fetales y 10.000 muertes maternas anuales en zonas endémicas para malaria. El secuestro de parásitos es la principal causa de daño en la placenta; la unión del receptor de sulfato de Condroitina A (CSA) expresado por el sincitiotrofoblasto (STB) (porción externa del trofoblasto) y el antígeno parasitario VAR2CSA expresado por los eritrocitos parasitados median la citohaderencia en este tejido.
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