Effects of two intravenouse dose levels of omeprazole on the gastric juice pH of healthy horses

  • Jhon D Ruiz Universidad CES
  • Juan E Ramírez Universidad CES
  • Ángel Lezcano Universidad CES
Keywords: equine, stomach, ulcer

Abstract

omeprazole suppresses gastric acid secretion and increases gastric juice pH by blocking the H+, K+ ATPase in the secretory membrane of parietal cells. Gastric juice pH below 4, long periods of no feed intake and stress are factors predisposing to gastric ulcers in horses. Objective: to determine the effect of 1 and 2 mg/Kg intravenous (IV) omeprazole on the gastric juice pH of Colombian Creole horses. Methods: seven horses were treated with two IV levels of omeprazole (1, and 2 mg/Kg body weight (BW)) in a crossover design. The omeprazole dose for each animal was reconstituted with 100 ml 0.9% NaCl. Gastric pH was measured using a portable pH-meter in stomach samples collected at time 0 (just before treatment), and 1, 2, 3, 5, 7, 9, 11, and 24 hours post-treatment. Results: the gastric pH at time 0 fluctuated from 1.6 to 3.2 in all horses. Both omeprazole doses (1 and 2 mg/Kg) significantly increased the gastric pH (pH > 4.6) from 1 to 11 hours after the treatment. At 24 hours post-treatment, pH of the group treated with 1.0 mg/Kg significantly decreased to 2.8 ± 0.3, but remained elevated at 5.7 ± 0.87 for the group treated with 2 mg/Kg. Conclusion: the study demonstrated that a single IV omeprazole dose of 2 mg/Kg, but not 1 mg/Kg, maintained gastric pH above 4 during 24 hours.

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Author Biography

Jhon D Ruiz, Universidad CES

Science Research Group (INCA-CES). Faculty of Veterinary Medicine and Animal Production.28 Universidad CES. Medellin, Colombia.

References

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Published
2016-10-14
How to Cite
Ruiz J. D., Ramírez J. E., & Lezcano Ángel. (2016). Effects of two intravenouse dose levels of omeprazole on the gastric juice pH of healthy horses. Revista Colombiana De Ciencias Pecuarias, 29(4), 283-287. Retrieved from https://revistas.udea.edu.co/index.php/rccp/article/view/325035
Section
Original research articles