MICROBIAL TRANSFORMATION OF ARYLPROPANOID CINNAMALDEHYDE BY THE PHYTOPATHOGEN FUNGUS Colletotrichum acutatum
DOI:
https://doi.org/10.17533/udea.vitae.1429Keywords:
Antifungal activity, enzymatic hydroxylation, bioreduction, chemoslectivity, regioselectivity,Abstract
Phytopathogenic fungi have the capacity to modify chemically a wide array of organic compounds turning
them into structurally related products. In this study, biotransformation of the substrate arylpropanoid
trans-cinnamaldehyde A achieved by the phylamentous phytopatogenic fungus Colletotrichum acutatum,
is evaluated; the process is carried out in liquid media culture Czapeck-Dox. The biotransformation
of the substrate A produces the metabolites cinnamyl alcohol B, 3-phenyl-1-propanol C, 3-phenyloxiranemethanol
D and 1-phenyl-1,3-propanediol E. The structures of metabolic products are determined
by gas chromatography coupled with mass spectrometry (GC-MS) and nuclear magnetic resonance of
proton and carbon (1H and 13C NMR). The process is marked by the tendency of the pathogen to produce
hydroxylations on the substituent of the aromatic ring. Additionally, it has the capability to reduce the
carbonyl group and the double bond. In the process, several metabolic products used like raw materials for different industries are generated. A possible metabolic pathway of the biotransformation of transcinnamaldehyde
by C. acutatum is also discussed.
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