Actividad antioxidante y contenido fenólico de los extractos provenientes de las bayas de dos especies del género vismia (Guttiferae)
Keywords:Guttiferae, fenoles totales, antranoides prenilados, vismiaquinona A, actividad antioxidante, radicales libres, total phenolics, prenylated anthranoids, vismiaquinone A, antioxidant activity, free radicals
AbstractEl material vegetal resultante del secado y molienda de las bayas de Vismia baccifera ssp. ferruginea y V. guianensis colectado en el Parque Regional Arví (Antioquia, Col.), se extrajo mediante percolación sucesiva con éter de petróleo, acetato de etilo y metanol. A los extractos se les determinó el rendimiento, contenido de fenoles totales y la capacidad captadora de radicales mediante los métodos de decoloración del DPPH• y ABTS•+. La mayor actividad captadora de radicales y el más alto contenido de compuestos fenólicos correspondieron al extracto en acetato de etilo, seguido por el de éter de petróleo. Mediante sucesivos fraccionamientos cromatográficos de los extractos activos se aislaron, los antranoides prenilados ferruginina A (1) y γ-hidroxiferruginina (2), y la antraquinona vismiaquinona A (3), cuya elucidación estructural fue llevada a cabo por métodos espectroscópicos y por comparación con los datos reportados en la literatura. Los datos obtenidos en los modelos in vitro establecen claramente el potencial antioxidante de los extractos de Vismia baccifera ssp. ferruginea y V. guianensis; esta actividad posiblemente está asociada con las características químicas de los metabolitos aislados.
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