Hepatitis A virus infection: Epidemiology and genetic diversity
DOI:
https://doi.org/10.17533/udea.iatreia.v28n2a06Keywords:
epidemiology, hepatitis, hepatitis A virus, public healthAbstract
Hepatitis A virus infection is a global public health problem. The virus has a wide range of distribution and it is the main cause of acute hepatitis transmitted by the enteric route in Latin America. The viral particle is stable under environmental conditions and conserves its infectivity for several weeks, enabling its transmission by contaminated water and food. Worldwide, different epidemiological patterns have been identified, which may change over time by modification of social and economic variables in the population such as vaccination and the improvement of hygiene and primary health conditions. This leaves new populations susceptible to infection. In Latin America the circulation of genotype I and subgenotypes A and B has been described, but more research is needed to provide the knowledge needed to manage the prevention and control plans for the worldwide reduction of the prevalence of infection. For this paper, a literature review was performed on the SciELO, PubMed and ScienceDirect databases under the search terms "Hepatitis A", "Epidemiology," "Seroprevalence" and "Infection." From the results obtained, only papers published in English and Spanish to describe epidemiological and molecular studies of interest in Latin America were included.
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References
(1.) Tapia-Conyer R, Santos JI, Cavalcanti AM, Urdaneta E, Rivera L, Manterola A, et al. Hepatitis A in Latin America: a changing epidemiologic pattern. Am J Trop Med Hyg. 1999 Nov;61(5):825–9.
(2.) Arguedas MR, Fallon MB. Hepatitis A. Curr Treat Options Gastroenterol. 2004 Jan;7(6):443–50.
(3.) Lavanchy D. Public health measures in the control of viral hepatitis: a World Health Organization perspective for the next millennium. J Gastroenterol Hepatol. 2002 Dec;17 Suppl:S452–9.
(4.) Cockayne EA. Catarrhal jaundice, sporadic and epidemic, and its relation to acute yellow atrophy of the liver. QJM. 1912 Oct;os6(1):1-29.
(5.) Cuthbert JA. Hepatitis A: old and new. Clin Microbiol Rev. 2001 Jan;14(1):38–58.
(6.) Nainan O V, Xia G, Vaughan G, Margolis HS. Diagnosis of hepatitis a virus infection: a molecular approach. Clin Microbiol Rev. 2006 Jan;19(1):63–79.
(7.) Jacobsen KH. The Global Prevalence of Hepatitis A Virus Infection and Susceptibility: A Systematic Review [Internet]. Geneva: World Health Organization; 2010. Available from: http://whqlibdoc.who.int/hq/2010/WHO_IVB_10.01_eng.pdf
(8.) Hollinger F, Emerson S. Hepatitis A Virus. In: Fields BN, Knipe DM, Howley PM, editors. Fields virology. 5th ed. Philadelphia: Williams & Wilkins; 2007.
(9.) Llorente-Molina D, Cedeño- Llorente S, Guzmán García J, Fuentes Príncipe PM. Actualidad en infecciones de transmisión sexual de etiología viral. Arch Med. 2009;5(2).
(10.) Deinhardt F, Holmes AW, Capps RB, Popper H. Studies on the transmission of human viral hepatitis to marmoset monkeys. I. Transmission of disease, serial passages, and description of liver lesions. J Exp Med. 1967 Apr;125(4):673–88.
(11.) OMS. Prevención y control de las hepatitis virales: marco para la acción mundial. Ginebra: Organización Mundial de la Salud; 2012.
(12.) Arauz-Ruiz P, Sundqvist L, García Z, Taylor L, Visoná K, Norder H, et al. Presumed common source out-breaks of hepatitis A in an endemic area confirmed by limited sequencing within the VP1 region. J Med Virol. 2001 Nov;65(3):449–56.
(13). OMS. Hepatitis A. World Health Organization; [cited 2014 Nov 21]; Available from: http://www.who.int/me-diacentre/factsheets/fs328/es/
(14.) Tanaka J. Hepatitis A shifting epidemiology in Latin America. Vaccine. 2000 Feb;18 Suppl 1:S57–60.
(15.) Instituto Nacional de Salud. Lineamiento Estratégico para la Introducción de la Vacuna contra la Hepatitis A en el Esquema del Programa Ampliado de Inmunizaciones –PAI.Colombia 2013 [Internet]. Bo-gotá; 2013 p. 29. Disponible en: http://www.minsalud.gov.co/Documentos%20y%20Publicaciones/Linea-mientos%20estrat%C3%A9gicos%20para%20la%20Introducci%C3%B3n%20de%20la%20vacuna%20con-tra%20la%20Hepatitis%20A.pdf
(16.) Feinstone SM, Kapikian AZ, Purceli RH. Hepatitis A: detection by immune electron microscopy of a vi-ruslike antigen associated with acute illness. Science. 1973 Dec;182(4116):1026–8.
(17.) Provost PJ, Hilleman MR. Propagation of human hepatitis A virus in cell culture in vitro. Proc Soc Exp Biol Med. 1979 Feb;160(2):213–21.
(18.) Robertson BH, Jansen RW, Khanna B, Totsuka A, Nai-nan O V, Siegl G, et al. Genetic relatedness of hepatitis A virus strains recovered from different geographical regions. J Gen Virol. 1992 Jun;73 ( Pt 6):1365–77.
(19.) Cohen JI, Ticehurst JR, Purcell RH, Buckler-White A, Baroudy BM. Complete nucleotide sequence of wild-type hepatitis A virus: comparison with different strains of hepatitis A virus and other picornaviruses. J Virol. 1987 Jan;61(1):50–9.
(20.) Jameel S, Aggarwal R. Tropical Infectious Diseases: Principles, Pathogens and Practice. In: Guerrant RL, Walker DH, Weller PF, editors. Tropical Infectious Diseases: Principles, Pathogens and Practice. 13th ed. Elsevier; 2011. p. 420–6.
(21.) Weitz M, Baroudy BM, Maloy WL, Ticehurst JR, Purcell RH. Detection of a genome-linked protein (VPg) of hepatitis A virus and its comparison with other picor-naviral VPgs. J Virol. 1986 Oct;60(1):124–30.
(22.) Aguirre S, Malirat V, Scodeller E, Mattion N. First full-length genomic sequence of a hepatitis A virus isolated in Argentina shows recombination between subgenotypes IA and IB. Virus Res. 2011 Jan;155(1):316–24.
(23.) Cristina J, Costa-Mattioli M. Genetic variability and molecular evolution of hepatitis A virus. Virus Res. 2007 Aug;127(2):151–7.
(24.) Debing Y, Neyts J, Thibaut HJ. Molecular biology and inhibitors of hepatitis A virus. Med Res Rev. 2014 Sep;34(5):895–917.
(25.) Feigelstock D, Thompson P, Mattoo P, Zhang Y, Kaplan GG. The human homolog of HAVcr-1 codes for a hepatitis A virus cellular receptor. J Virol. 1998 Aug;72(8):6621–8.
(26.) Chigor VN, Okoh AI. Quantitative RT-PCR detection of hepatitis A virus, rotaviruses and enteroviruses in the Buffalo River and source water dams in the Eastern Cape Province of South Africa. Int J Environ Res Public Health. 2012 Nov;9(11):4017–32.
(27.) Abad FX, Pintó RM, Bosch A. Survival of enteric viruses on environmental fomites. Appl Environ Microbiol. 1994 Oct;60(10):3704–10.
(28.) Mbithi JN, Springthorpe VS, Sattar SA. Comparative in vivo efficiencies of hand-washing agents against hepatitis A virus (HM-175) and poliovirus type 1 (Sa-bin). Appl Environ Microbiol. 1993 Oct;59(10):3463–9.
(29.) Prado T, Fumian TM, Miagostovich MP, Gaspar AMC. Monitoring the hepatitis A virus in urban wastewater from Rio de Janeiro, Brazil. Trans R Soc Trop Med Hyg. 2012 Feb;106(2):104–9.
(30.) Yanez LA, Lucero NS, Barril PA, Díaz MDP, Tenaglia MM, Spinsanti LI, et al. Evidence of hepatitis A virus circulation in central Argentina: seroprevalence and environmental surveillance. J Clin Virol. 2014 Jan;59(1):38–43.
(31.) Appleton H, Banks M, Dentinger C, Chong GT. Food-borne viral hepatitis. In: Simjee S, editor. Foodborne diseases. New Jersey: Humana Press; 2007. p. 175–214.
(32.) Peterson DA, Hurley TR, Hoff JC, Wolfe LG. Effect of chlorine treatment on infectivity of hepatitis A virus. Appl Environ Microbiol. 1983 Jan;45(1):223–7.
(33.) Li JW, Xin ZT, Wang XW, Zheng JL, Chao FH. Mechanisms of inactivation of hepatitis A virus in water by chlorine dioxide. Water Res. 2004 Mar;38(6):1514–9.
(34.) Vaughan G, Xia G, Forbi JC, Purdy MA, Rossi LMG, Spradling PR, et al. Genetic relatedness among hepatitis A virus strains associated with food-borne out-breaks. PLoS One. 2013 Jan;8(11):e74546.
(35.) Rincón CJ, Rodríguez-Malagón N, Mariño C, Mojica JA, de la Hoz-Restrepo F. [Assessing the force of hepati-tis A virus infection in Colombia by applying catalytic models]. Rev Salud Publica (Bogota). 14(2):282–95.
(36.) Franco E, Meleleo C, Serino L, Sorbara D, Zaratti L. Hepatitis A: Epidemiology and prevention in developing countries. World J Hepatol. 2012 Mar;4(3):68–73.
(37.) Gust ID. Epidemiological patterns of hepatitis A in di-fferent parts of the world. Vaccine. 1992 Jan;10 Suppl 1:S56–8.
(38.) Jacobsen KH, Wiersma ST. Hepatitis A virus seropre-valence by age and world region, 1990 and 2005. Vaccine. 2010 Sep;28(41):6653–7.
(39.) Organización Mundial de la Salud. Vacunas contra la hepatitis A. Documento de posición de la OMS – Junio de 2012. Boletín epidemiológico Semanal [Internet]. 2012 Jul;87(28-29):261–76. Disponible en: http://www.who.int/immunization/position_papers/WER_Po-sition_Paper_HepatitisA_Spanish_Aug.2012.pdf
(40.) David AM. Hepatitis A outbreaks-methods of intervention in South-East Asian countries. Int J Infect Dis. 2004 Jul;8(4):201–9.
(41.) Ciocca M, Moreira-Silva SF, Alegría S, Galoppo MC, Ruttiman R, Porta G, et al. Hepatitis A as an etiologic agent of acute liver failure in Latin America. Pediatr Infect Dis J. 2007 Aug;26(8):711–5.
(42.) Vitral CL, Ospina FLN, Artimos S, Melgaço JG, Cruz OG, de Paula VS, et al. Declining prevalence of hepatitis A virus antibodies among children from low socioeconomic groups reinforces the need for the implementation of hepatitis A vaccination in Brazil. Mem Inst Oswaldo Cruz. 2012 Aug;107(5):652–8.
(43.) Ljunggren KE, Patarroyo ME, Engle R, Purcell RH, Gerin JL. Viral hepatitis in Colombia: a study of the “hepatitis of the Sierra Nevada de Santa Marta”. He-patology. 1985 Apr;5(2):299–304.
(44.) Vega M, Alvarez C, Arango AE, Yepes N, Sepúlveda E, Restrepo JC, et al. Frecuencia y distribución de anticuerpos positivos contra la hepatitis A. Acta Med Colomb. 2003;28(2):71-75.
(45.) Moreno S, Alvarado MV, Bermúdez A, Gutiérrez MF. Análisis filogenético de las cepas de rotavirus y vi-rus de la hepatitis A encontradas en agua de consumo en el municipio de Quibdó, Chocó. Biomédica. 2009;(29):209–17.
(46.) Peláez D, Rodríguez JA, Rocha EL, Rey GJ. Estandarización de un método de concentración y detección de virus entéricos en aguas de consumo. Biomédica. 2010;30(2):276-86.
(47.) Instituto Nacional de Salud. Protocolo de Vigilancia en Salud Pública. Hepatitis A [Internet]. Bogotá; 2014 p. 32. Disponible en: http://www.ins.gov.co/lineas-de-accion/Subdireccion-Vigilancia/sivigila/Protocolos SIVIGILA/PRO Hepatitis A.pdf
(48.) Ott JJ, Irving G, Wiersma ST. Long-term protective effects of hepatitis A vaccines. A systematic review. Vaccine. 2012;31(1):3-11.
(49.) Rico-Hesse R, Pallansch MA, Nottay BK, Kew OM. Geographic distribution of wild poliovirus type 1 ge-notypes. Virology. 1987 Oct;160(2):311–22.
(50.) Joshi MS, Walimbe AM, Chitambar SD. Evaluation of genomic regions of hepatitis A virus for phylogenetic analysis: Suitability of the 2C region for genotyping. J Virol Methods. 2008 Oct;153(1):36–42.
(51.) Desbois D, Couturier E, Mackiewicz V, Graube A, Le-tort M-J, Dussaix E, et al. Epidemiology and genetic characterization of hepatitis A virus genotype IIA. J Clin Microbiol. 2010 Sep;48(9):3306–15.
(52.) Holmes AW, Deinhardt F, Wolfe L, Froesner G, Paterson D, Casto B, et al. Specific neutralization of human hepatitis type A in marmoset monkeys. Nature. 1973 Jun;243(5407):419–20.
(53.) Theamboonlers A, Abe K, Thongmee C, Poovorawan Y. Complete coding sequence and molecular analysis of hepatitis A virus from a chimpanzee with fulminant hepatitis. J Med Primatol. 2012 Feb;41(1):11–7.
(54.) Nainan O V, Margolis HS, Robertson BH, Balayan M, Brinton MA. Sequence analysis of a new hepatitis A virus naturally infecting cynomolgus macaques (Macaca fascicularis). J Gen Virol. 1991 Jul;72 ( Pt 7): 1685–9.
(55.) Tsarev SA, Emerson SU, Balayan MS, Ticehurst J, Pur-cell RH. Simian hepatitis A virus (HAV) strain AGM-27: comparison of genome structure and growth in cell culture with other HAV strains. J Gen Virol. 1991 Jul;72 ( Pt 7):1677–83.
(56.) Endo K, Takahashi M, Masuko K, Inoue K, Akahane Y, Okamoto H. Full-length sequences of subgenotype IIIA and IIIB hepatitis A virus isolates: characterization of genotype III HAV genomes. Virus Res. 2007 Jun;126(1-2):116–27.
(57.) Jansen RW, Siegl G, Lemon SM. Molecular epidemiology of human hepatitis A virus defined by an antigen-capture polymerase chain reaction method. Proc Natl Acad Sci U S A. 1990 Apr;87(8):2867–71.
(58.) Hutin YJ, Pool V, Cramer EH, Nainan O V, Weth J, Wi-lliams IT, et al. A multistate, foodborne outbreak of hepatitis A. National Hepatitis A Investigation Team. N Engl J Med. 1999 Feb 25;340(8):595–602.
(59.) Costa-Mattioli M, Cristina J, Romero H, Perez-Bercof R, Casane D, Colina R, et al. Molecular evolution of hepatitis A virus: a new classification based on the complete VP1 protein. J Virol. 2002 Sep;76(18):9516–25.
(60). Bosch A, González-Dankaart JF, Haro I, Gajardo R, Pé-rez JA, Pintó RM. A new continuous epitope of hepa-titis A virus. J Med Virol. 1998 Feb;54(2):95–102.
(61.) Sulbaran Y, Gutierrez CR, Marquez B, Rojas D, San-chez D, Navas J, et al. Hepatitis A virus genetic diversi-ty in Venezuela: exclusive circulation of subgenotype IA and evidence of quasispecies distribution in the isolates. J Med Virol. 2010 Nov;82(11):1829–34.
(62.) Worobey M, Holmes EC. Evolutionary aspects of recombination in RNA viruses. J Gen Virol. 1999 Oct;80 ( Pt 10):2535–43.
(63.) Costa-Mattioli M, Ferré V, Casane D, Perez-Bercoff R, Coste-Burel M, Imbert-Marcille BM, et al. Evidence of recombination in natural populations of hepatitis A virus. Virology. 2003 Jun;311(1):51–9.
(64.) Lemon SM, Murphy PC, Shields PA, Ping LH, Feins-tone SM, Cromeans T, et al. Antigenic and genetic variation in cytopathic hepatitis A virus variants ari-sing during persistent infection: evidence for genetic recombination. J Virol. 1991 Apr;65(4):2056–65.
(65.) Betancourt WQ, Querales L, Sulbaran YF, Rodriguez-Diaz J, Caraballo L, Pujol FH. Molecular characteri-zation of sewage-borne pathogens and detection of sewage markers in an urban stream in Caracas, Venezuela. Appl Environ Microbiol. 2010 Mar;76(6): 2023–6.
(66.) Lu L, Ching KZ, de Paula VS, Nakano T, Siegl G, Weitz M, et al. Characterization of the complete genomic sequence of genotype II hepatitis A virus (CF53/Berne isolate). J Gen Virol. 2004 Oct;85(Pt 10):2943–52.
(67.) Chitambar S, Joshi M, Lole K, Walimbe A, Vaidya S. Cocirculation of and coinfections with hepatitis A virus subgenotypes IIIA and IB in patients from Pune, western India. Hepatol Res. 2007 Feb;37(2):85–93.
(68.) Costa-Mattioli M, Di Napoli A, Ferré V, Billaudel S, Pe-rez-Bercoff R, Cristina J. Genetic variability of hepati-tis A virus. J Gen Virol. 2003 Dec;84(Pt 12):3191–201.
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