ANTIPLASMODIAL ACTIVITY OF APORPHINE ALKALOIDS FROM Rollinia pittieri AND Pseudomalmea boyacana (ANNONACEAE)

  • Edison J. OSORIO D.
  • Guillermo L. MONTOYA P.
  • Katalina MUÑOZ D.
  • Gabriel J. ARANGO A.
Keywords: antiplasmodial activity, Annonaceae, colombian plants and aporphine alkaloids.

Abstract

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In the course of from ethnobotanical or chemotaxonomical studies on biologically active substances with

antiparasitic effects from Anonaceae colombian plants, substantial antiplasmodial activity was observed

from the ethyl acetate extract of the stem of Rollinia pittieri and Pseudomalmea boyacana (Annonaceae),

the alkaloids isolated from these were studied. Of the alkaloids, liriodenine exhibited the highest activity

against chloroquine sensitive and chloroquine resistant strains of Plasmodium falciparum (CI50 = 8.0-10.0 μg/ml). In addition, inhibition of β-hematin formation (If????-h) by isolated compounds was evaluated

(Ifs-h). O-methylmoschatoline and melosmine showed inhibition percentage >96% at 2 mg/ml. Some

degree of cytotoxic to U-937 cells activity was observed by oxoporphine alkaloids.

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Published
2009-02-03
How to Cite
OSORIO D. E. J., MONTOYA P. G. L., MUÑOZ D. K., & ARANGO A. G. J. (2009). ANTIPLASMODIAL ACTIVITY OF APORPHINE ALKALOIDS FROM <I>Rollinia pittieri</I> AND <I>Pseudomalmea boyacana</I&gt; (ANNONACEAE). Vitae, 13(1). Retrieved from https://revistas.udea.edu.co/index.php/vitae/article/view/525
Section
Natural Products