EFFECT OF EXTRACTION TECHNIQUE OF RUTA GRAVEOLENS ON ANTITYROSINASE ACTIVITY AND CORRELATION AMONGST INHIBITORY ACTIVITY, PHENOLIC COMPOUNDS CONTENT AND CYTOTOXICITY

  • Katalina MUÑOZ D.
  • Julián A. LONDOÑO L.
  • Gabriel J. ARANGO A.
  • Jelver A. SIERRA R.
  • Karent E. BRAVO M.
Keywords: Cytotoxicity, tyrosinase inhibition, Ruta graveolens, skin lightening agents

Abstract

Skin pigmentation is the consequence of melanin production and dispersion, this pigment is formed

by a successive oxidation of L-Tyrosine into L-Dihydroxyphenylalanine (L-DOPA) and dopaquinone

by Tyrosinase enzyme. Skin pigmentation irregularities become an aesthetic problem for many people.

Therefore there is a big interest in research on products with skin lightening properties. In order to find

inhibitors of Tyrosinase enzyme from natural product, extracts of Ruta graveolens (R. graveolens) were

studied by using different extraction methods. The inhibition of the oxidation of L-Tyrosine catalyzed

by mushroom tyrosinase is determined and correlated with cytotoxicity and the content of phenolic

compounds, because inhibitory activity on the enzyme has been reported of these kind of compounds. It was found that the extraction method affects strongly the content of phenolic compounds of the extract

and the cytotoxicity as well, in contrast with the inhibition of tyrosinase activity which remains almost

unaffected.

|Abstract
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Published
2009-02-05
How to Cite
MUÑOZ D. K., LONDOÑO L. J. A., ARANGO A. G. J., SIERRA R. J. A., & BRAVO M. K. E. (2009). EFFECT OF EXTRACTION TECHNIQUE OF RUTA <I>GRAVEOLENS</I&gt; ON ANTITYROSINASE ACTIVITY AND CORRELATION AMONGST INHIBITORY ACTIVITY, PHENOLIC COMPOUNDS CONTENT AND CYTOTOXICITY. Vitae, 14(2). Retrieved from https://revistas.udea.edu.co/index.php/vitae/article/view/616
Section
Natural Products