PERFORMANCE OF THE JOUYBAN-ACREE MODEL FOR CORRELATING THE SOLUBILITY OF INDOMETHACIN AND ETHYLHEXYL TRIAZONE IN ETHYL ACETATE + ETHANOL MIXTURES

Authors

  • Miller A. RUIDIAZ M. Grupo de Investigaciones Farmacéutico-Fisicoquímicas. Departamento de Farmacia. Facultad de Ciencias. Universidad Nacional de Colombia.
  • Sylvia J. RODRÍGUEZ D. Grupo de Investigaciones Farmacéutico-Fisicoquímicas. Departamento de Farmacia. Facultad de Ciencias.
  • Paula C. NEITA R. Grupo de Investigaciones Farmacéutico-Fisicoquímicas. Departamento de Farmacia. Facultad de Ciencias. Universidad Nacional de Colombia.
  • Diana M. CRISTANCHO B. Grupo de Investigaciones Farmacéutico-Fisicoquímicas. Departamento de Farmacia. Facultad de Ciencias. Universidad Nacional de Colombia.
  • Fleming MARTÍNEZ R. Grupo de Investigaciones Farmacéutico-Fisicoquímicas. Departamento de Farmacia. Facultad de Ciencias. Universidad Nacional de Colombia.

Keywords:

Indomethacin, ethylhexyl triazone, solubility, ethanol, ethyl acetate, solvent mixtures, Jouyban-Acree equation.

Abstract


This work reports the experimental volumetric properties and also the saturated solubility of indomethacin and ethylhexyl triazine in ethyl acetate + ethanol mixtures at 293.15 to 313.15 K and evaluates the validity of the Jouyban-Acree (J & A) model to correlate the solubility of these compounds in ethyl acetate + ethanol solvent mixtures. The solubility correlation is studied as a function of temperature and cosolvent composition. The J & A model requires only the experimental solubility values in the pure solvents at all the temperatures under study. The calculated values by using both compounds deviate as mean in 30% from experimental solubility values.
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Published

2010-11-09

How to Cite

RUIDIAZ M., M. A., RODRÍGUEZ D., S. J., NEITA R., P. C., CRISTANCHO B., D. M., & MARTÍNEZ R., F. (2010). PERFORMANCE OF THE JOUYBAN-ACREE MODEL FOR CORRELATING THE SOLUBILITY OF INDOMETHACIN AND ETHYLHEXYL TRIAZONE IN ETHYL ACETATE + ETHANOL MIXTURES. Vitae, 17(3), 309–316. Retrieved from https://revistas.udea.edu.co/index.php/vitae/article/view/7438

Issue

Section

Pharmaceutical Industry

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