EXTENDED HILDEBRAND SOLUBILITY APPROACH FOR NAPROXEN SOLUBILITY ESTIMATION IN ETHANOL + WATER COSOLVENT MIXTURES

Authors

  • Diana M. ARAGON N.
  • Diana P. PACHECO A.
  • Millar A. RUIDIAZ M.
  • Alejandro D. SOSNIK
  • Fleming MARTÍNEZ R.

DOI:

https://doi.org/10.17533/udea.vitae.773

Keywords:

naproxen, solubility estimation, Extended Hildebrand Solubility Approach, cosolvent mixtures

Abstract

Naproxen (NAP) is a widely used non-steroidal anti-inflammatory drug; however their physicochemical

properties have not been thoroughly studied. In this work, Extended Hildebrand Solubility Approach

(EHSA) developed by Martin et al was applied to evaluate the solubility of NAP in ethanol + water

cosolvent mixtures at 298.15 K ± 0.05 K. Molar volume and solubility parameter values of NAP, were

calculated according to Fedors and van Krevelen methods. A good predictive capacity of EHSA was found

using regular polynomial models in fifth order for NAP, when the W interaction parameter is related

to the solubility parameter of the cosolvent mixtures. Nevertheless, deviations on estimated solubility

obtained respect to experimental solubility values had shown the same order compared with those

obtained directly by logarithm empirical regression means of experimental solubilities as a function of

cosolvent solubility parameters

|Abstract
= 136 veces | PDF (ESPAÑOL (ESPAÑA))
= 110 veces|

Downloads

Download data is not yet available.

Published

16-02-2009

How to Cite

ARAGON N., D. M., PACHECO A., D. P., RUIDIAZ M., M. A., SOSNIK, A. D., & MARTÍNEZ R., F. (2009). EXTENDED HILDEBRAND SOLUBILITY APPROACH FOR NAPROXEN SOLUBILITY ESTIMATION IN ETHANOL + WATER COSOLVENT MIXTURES. Vitae, 15(1). https://doi.org/10.17533/udea.vitae.773

Issue

Section

New Section Title Here

Most read articles by the same author(s)