Cytogenetic and morphologic study of spontaneous abortions products in Medellín, Colombia

Abstract

Eighty tour spontaneous abortion products, with gestational age under 20 weeks, were collected in ditterent obstetric and gynecologic services trom Medellin-Colombia between September 1996 and October 1997; they were studied both morphologically and cytogenetically. Sixteen of those products were discarded because of contamination or absence of suitable tissues for the study In 60 of the remaining 68 products (88°/~) cultures for cytogenetic studies were establishedJ and they were succesful in 34 cases (56J7%). Seventeen of. these (50%) showed an abnormal karyotype with the following chromosomal anomalies: X monosomies 10 (58J8%), mosaicisms 5 (29,4%)J trisomies 1 (5,9%), and tetráploidy 1 (5J9%). From the 68 products, a morphologic study was performed in 21 cases (3 embryos and 18 fetuses). Twelve products (2 embryos and 10 fetuses; 57 J 1 %) had external and/or jnternal anomalies This study of spontaneous abortions with gestational age under 20 weeks is the first in our country, and its results are similar to those published from other centers.