Vitamin D and Pain: A Critical Reflection of the Literature
DOI:
https://doi.org/10.17533/udea.penh.v23n1a08Keywords:
Vitamin D, Vitamin D Deficiency, Pain, Pain management, Quality of lifeAbstract
Background: More than half of the global population reports low serum levels of 25(OH)D. Vitamin D is associated with several biological functions, like regulation of serum phosphorus and calcium, and may have possible effects on pain. The objective of this review is to understand the validity and applicability of the results with respect to the efficacy of vitamin D as a protective factor for pain. Reflection: Limited dietary sources and low levels of vitamin D highlight the importance of its deficiency as a possible risk factor for pain. This makes it necessary to verify the consensus that confirms the association between optimal levels of vitamin D and the risk of pain. Conclusion: Some evidence exists on vitamin D deficiency and its relationship to different types of pain. Although the data remain inconclusive, vitamin D supplements have not always been associated with pain improvement.
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Fuentes-Barría H, Aguilera-Eguía R, González-Wong C. El rol de la vitamina D en la prevención de caídas en sujetos con sarcopenia. Rev Chil Nutr. 2018;45(3):279-84. https://dx.doi.org/10.4067/s0717-75182018000400279
Fuentes-Barría H, Aguilera-Eguía R, Urbano-Cerda S, Vera-Aguirre V, González-Wong C. El rol de la vitamina D en la prevención de caídas en sujetos con sarcopenia parte II: Requerimiento de Vitamina D del adulto mayor. Rev Chil Nutr. 2020;47(5):830-5. http://dx.doi.org/10.4067/s0717-75182020000500830
González-Wong C, Fuentes-Barría H, Aguilera-Eguía R, Urbano-Cerda S, Vera-Aguirre V. El rol de la vitamina D en el riesgo de preeclampsia: revisión narrativa. Rev Chil Nutr. 2021;48(1):118-25. http://dx.doi.org/10.4067/S0717-75182021000100118
Bizzaro G, Antico A, Fortunato A, Bizzaro N. Vitamin D and autoimmune diseases: ¿Is vitamin D Receptor (VDR) Polymorphism the Culprit? Isr Med Assoc J. 2017;19:438-43. Disponible en: https://www.ima.org.il/FilesUploadPublic/IMAJ/0/247/123628.pdf
Valero MA, Hawkins F. Metabolismo, fuentes endógenas y exógenas de vitamina D. REEMO. 2007;16(4):63-70. https://doi.org/10.1016/S1132-8460(07)73506-7
Liu J, Dong Y, Lu C, Wang Y, Peng L, Jiang M, et al. Meta-analysis of the correlation between vitamin D and lung cancer risk and outcomes. Oncotarget. 2017;6;8(46):81040-51. https://doi.org/10.18632/oncotarget.18766
Lucato P, Solmi M, Maggi S, Bertocco A, Bano G, Trevisan C, et al. Low vitamin D levels increase the risk of type 2 diabetes in older adults: A systematic review and metaanalysis. Maturitas. 2017;100:8-15. https://doi.org/10.1016/j.maturitas.2017.02.016
Wu Z, Malihi Z, Stewart AW, Lawes CM, Scragg R. The association between vitamin D concentration and pain: a systematic review and meta-analysis. Public Health Nutr. 2018;21(11):2022-2037. https://doi.org/10.1017/S1368980018000551
Alcántara A. Vitamina D y dolor crónico. Rev Soc Esp Dolor. 2016;23(4):211-4. https://doi.org/10.20986/resed.2016.3429/2016
Herrera E, Yomayusa N, Low E, Oliveros JD, Mendivelso F, Gómez OV, et al. Recomendaciones para el uso racional de la prueba 25-Hidroxivitamina D resumen de política. Rev Colom Nefrol. 2019;6(2):179-92. https://dx.doi.org/10.22265/acnef.6.2.346
Holick MF. The vitamin D deficiency pandemic: Approaches for diagnosis, treatment and prevention. Rev Endocr Metab Disord. 2017;18:153-65. https://doi.org/10.1007/s11154-017-9424-1
Holick MF, Binkley NC, Bischoff-Ferrari HA, Gordon CM, Hanley DA, Heaney RP, et al. Evaluation, Treatment, and Prevention of Vitamin D Deficiency: An Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab. 2011;96(7):1911-30. https://doi.org/10.1210/jc.2011-0385
Matossian-Motley DL, Drake DA, Samimi JS, Camargo CA Jr, Quraishi SA. Association between serum 25(OH)D level and nonspecific musculoskeletal pain in acute rehabilitation unit patients. J Parenter Enteral Nutr. 2016;40(3):367-73. https://doi.org/10.1177/0148607114555909
Powanda MC. Is there a role for vitamin D in the treatment of chronic pain? Inflammopharmacology. 2014;22(6):327-32. https://doi.org/10.1007/s10787-014-0219-7
Hirani V, Blyth FM, Naganathan V, Cumming RG, Le Couteur DG, Handelsman DJ, et al. Active vitamin D (1,25 dihydroxyvitamin D) is associated with chronic pain in older Australian men: The Concord Health and Ageing in Men Project. J Gerontol A Biol Sci Med Sci. 2015;70(3):387-95. https://doi.org/10.1093/gerona/glu126
Hong Q, Xu J, Xu S, Lian L, Zhang M, Ding C. Associations between serum 25-hydroxyvitamin D and disease activity, inflammatory cytokines and bone loss in patients with rheumatoid arthritis. Rheumatology. 2014;53(11):1994-2001. https://doi.org/10.1093/rheumatology/keu173
Le Goaziou MF, Kellou N, Flori M, Perdrix C, Dupraz C, Bodier E, et al. Vitamin D supplementation for diffuse musculoskeletal pain: Results of a before-and-after study. Eur J Gen Pract. 2014;20(1):3-9. https://doi.org/10.3109/13814788.2013.825769
Rosen CJ, Abrams SA, Aloia JF, Brannon PM, Clinton SK, Durazo-Arvizu RA, et al. IOM committee members respond to Endocrine Society vitamin D guideline. J Clin Endocrinol Metab. 2012;97(4):1146-52. https://doi.org/10.1210/jc.2011-2218
Bouillon R, Van Schoor NM, Gielen E, Boonen S, Mathieu C, Vanderschueren D, et al. Optimal vitamin D status: a critical analysis on the basis of evidence-based medicine. J Clin Endocrinol Metab. 2013;98:E1283-304. https://doi.org/10.1210/jc.2013-1195
Yong, W.C., Sanguankeo, A. & Upala, S. Effect of vitamin D supplementation in chronic widespread pain: a systematic review and meta-analysis. Clin Rheumatol. 2017;36:2825-33. https://doi.org/10.1007/s10067-017-3754-y
Zadro J, Shirley D, Ferreira M, Carvalho-Silva AP, Lamb SE, Cooper C, et al. Mapping the Association between Vitamin D and Low Back Pain: A Systematic Review and Meta-Analysis of Observational Studies. Pain Physician. 2017;20(7):611-40. https://doi.org/10.36076/ppj/2017.7.611
Zadro JR, Shirley D, Ferreira M, Carvalho-Silva AP, Lamb SE, Cooper C, et al. Is Vitamin D Supplementation Effective for Low Back Pain? A Systematic Review and Meta-Analysis. Pain Physician. 2018;21(2):121-45. https://doi.org/10.36076/ppj.2018.2.121
Gómez de Tejada Romero MJ. Extraskeletal effects of vitamin D. Rev Osteoporos Metab Miner. 2014;6(Suppl 1):11-8. https://doi.org/10.4321/S1889-836X2014000500003
Ibarra E. Una nueva definición de “dolor”: un imperativo de nuestros días. Rev Soc Esp Dolor. 2006;13(2):65-72. Disponible en: http://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S1134-80462006000200001&lng=es
Puebla F. Tipos de dolor y escala terapéutica de la OMS: dolor iatrogénico. Oncología. 2005;28(3):33-7. https://doi.org/10.4321/S0378-48352005000300006
Wu Z, Malihi Z, Stewart AW, Lawes CM, Scragg R. Effect of Vitamin D Supplementation on Pain: A Systematic Review and Metaanalysis. Pain Physician. 2016;19(7):415-27. https://doi.org/10.36076/ppj/2016.19.415
Makrani AH, Afshari M, Ghajar M, Forooghi Z, Moosazadeh M. Vitamin D and fibromyalgia: a meta-analysis. Korean J Pain. 2017;30(4):250-7. https://doi.org/10.3344/kjp.2017.30.4.250.
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