Vitamin B12 and lipid concentration in normoglycemic adults
an analytical study
Keywords:
Vitamin B12, Lipids, Correlation of data, lineal models, Healthy LifestyleAbstract
Background: Vitamin B12 has been associated with an adverse lipid profile through biochemical and epigenetic mechanisms. Objective: to analyze the relationship between vitamin B12 and lipids in normoglycemic adults. Methodology: observational, analytical and cross-sectional study, based on a database of 4000 adults. The variables were: high-density lipoproteins (HDL), low-density lipoproteins (LDL), total cholesterol and triglycerides. The Chi-square test, Spearman correlation, multiple linear regression and principal components analysis were used. Results: The average vitamin B12 was higher in groups with high lipids. The correlation between vitamin B12 and HDL was low and positive, with LDL low and negative, with triglycerides low and negative, and with total cholesterol there was no statistical significance. In the multiple linear regression model, it was found that the vitamin B12 level score decreased 1.66 points for each mg/dl of additional cholesterol, increased 5.42 per mg/dl of HDL, 0.29 points per mg/dl triglycerides, and decreased 1.29 per year of age. In the principal components analysis, the second component grouped the variables vitamin B12 and HDL. Conclusions: Cholesterol, triglyceride, HDL, and LDL levels are related to vitamin B12 concentrations in normoglycemic adults.
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