Función de las vitaminas D, E y K en condiciones especiales

salud y enfermedad

Autores/as

  • Juan Pablo Giraldo Gallego Universidad CES
  • María Camila Arbeláez Marulanda Universidad CES
  • Faiber Alexis Jaramillo Yepes Universidad CES
  • Caterine Henao Roldán Universidad CES
  • Angélica María Muñoz Contreras Universidad CES

DOI:

https://doi.org/10.17533/udea.penh.v24n1a07

Palabras clave:

vitamina D, vitamina E, vitamina K, enfermedad, dosis, ingesta, huesos, cáncer, enfermedades cardiovasculares, sistema musculoesquelético

Resumen

Antecedentes: se cuenta con recomendaciones de energía y nutrientes para población sana, sin embargo, nutrientes como la vitamina D, E, K se les atribuyen funciones importantes en diferentes situaciones de salud. Objetivo: explorar la efectividad de dosis dietarias y de suplementos de las vitaminas D, E y K en condiciones especiales de salud y enfermedad. Materiales y métodos: se realizó una búsqueda de documentos en las bases de datos Pubmed, Scopus, Sciencedirect, Lilacs, Scielo, Ebsco, y en textos especializados utilizando palabras claves: “vitamin D”, “vitamin E”, “vitamin K”, “health”, “disease”, “nutritional recommendations” Resultados: hay un importante número de estudios y revisiones sistemáticas que contribuyen con la evidencia y la discusión en cuanto efecto, dosis y tiempo las cuales arrojaron tanto desenlaces positivos como nulos Conclusión:  los efectos de la vitamina D dietaria en la salud ósea están bien documentados y los suplementos de la misma acompañados de calcio están indicados en grupos poblaciones con riesgo de osteoporosis, pero no en otras condiciones clínicas. No hay suficiente evidencia sobre los beneficios de la vitamina E en el manejo o prevención de enfermedad hepática, cardiovascular o cáncer. La vitamina K podría ser importante en la salud ósea, sobre otras condiciones clínicas.

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Biografía del autor/a

Juan Pablo Giraldo Gallego, Universidad CES

Estudiante del último semestre de pregrado Nutrición y Dietética.

María Camila Arbeláez Marulanda, Universidad CES

Estudiante del último semestre de pregrado Nutrición y Dietética.

Faiber Alexis Jaramillo Yepes, Universidad CES

Phd. Ciencias Farmacéuticas y Alimentarias. Docente de la Facultad Ciencias de la Nutrición y los Alimentos.

Caterine Henao Roldán, Universidad CES

Mg. Nutrición infantil. Docente de la Facultad Ciencias de la Nutrición y los Alimentos.

Angélica María Muñoz Contreras, Universidad CES

Phd. Ciencias Básicas Biomédicas. Docente de la Facultad Ciencias de la Nutrición y los Alimentos.

Citas

Olveira G. Gonzalo M. Actualización en requerimientos nutricionales. Endocrinol Nutr. 2007;54(2):17-29. https://doi.org/10.1016/S1575-0922(07)71523-1

Colombia. Ministerio de salud. Resolución 3803 de 2016, agosto 22, por el cual se expide las recomendaciones de Ingesta de Energía y Nutrientes- RIEN para la población colombiana y se dictan otras disposiciones. Bogotá: El Ministerio;2016. Disponible en: en: https://www.minsalud.gov.co/Normatividad_Nuevo/Resoluci%C3%B3n%203803%20de%202016.pdf

Bhattarai HK, Shrestha S, Rokka K, Shakya R. Vitamin D, Calcium, Parathyroid Hormone, and Sex Steroids in Bone Health and Effects of Aging. J Osteoporos.2020;2020:1-10. https://doi.org/10.1155/2020/9324505

Rai V, Agrawal DK. Role of Vitamin D in Cardiovascular Diseases. Endocrinol Metab Clin North Am. 2017;46(4):1039-59. https://doi.org/10.1016/j.ecl.2017.07.009

Grant WB. Review of Recent Advances in Understanding the Role of Vitamin D in Reducing Cancer Risk: Breast, Colorectal, Prostate, and Overall Cancer. Anticancer Res. 2020;40(1):491-9. https://doi.org/10.21873/anticanres.13977

Bersani FS, Ghezzi F, Maraone A, Vicinanza R, Cavaggioni G, Biondi M, et al. The relationship between Vitamin D and depressive disorders. Riv Psichiatr. 2019;54(6):229-34. https://doi.org/10.1708/3281.32541

Pekmezci D. Chapter eight - Vitamin E and Immunity. En: Litwack G, editor. Vitamins & Hormones [Internet]. Academic Press; 2011 [citado 13 de abril de 2021]. p. 179-215. (Vitamins and the Immune System; vol. 86). https://doi.org/10.1016/B978-0-12-386960-9.00008-3

Halder M, Petsophonsakul P, Akbulut AC, Pavlic A, Bohan F, Anderson E, et al. Vitamin K: Double Bonds beyond Coagulation Insights into Differences between Vitamin K1 and K2 in Health and Disease. Int J Mol Sci. 2019;20(4). https://doi.org/10.3390/ijms20040896

Tsugawa N, Shiraki M. Vitamin K Nutrition and Bone Health. Nutrients. 2020;12(7). https://doi.org/10.3390/nu12071909

Palmer CR, Blekkenhorst LC, Lewis JR, Ward NC, Schultz CJ, Hodgson JM, et al. Quantifying dietary vitamin K and its link to cardiovascular health: a narrative review. Food Funct. 2020;11(4):2826-37. https://doi.org/10.1039/C9FO02321F

Karamzad N, Maleki V, Carson-Chahhoud K, Azizi S, Sahebkar A, Gargari BP. A systematic review on the mechanisms of vitamin K effects on the complications of diabetes and pre-diabetes. Biofactors. 2020;46(1):21-37. https://doi.org/10.1002/biof.1569

Ziegler EE. Conocimientos actuales sobre nutrición. Pan American Health Org; 1997. 756 p.

Charoenngam N, Shirvani A, Holick MF. Vitamin D for skeletal and non-skeletal health: What we should know. J Clin Orthop Trauma. 2019;10(6):1082-93. https://doi.org/10.1016/j.jcot.2019.07.004

Chang S-W, Lee H-C. Vitamin D and health - The missing vitamin in humans. Pediatr Neonatol. 2019;60(3):237-44. https://doi.org/10.1016/j.pedneo.2019.04.007

Santoro D, Sebekova K, Teta D, De Nicola L. Extraskeletal Functions of Vitamin D. Biomed Res Int. 2015:294719:1-2. https://doi.org/10.1155/2015/294719

Cummings SR, Melton LJ. Epidemiology and outcomes of osteoporotic fractures. Lancet. 2002;359(9319):1761-7. https://doi.org/10.1016/S0140-6736(02)08657-9

Bischoff-Ferrari HA, Kiel DP, Dawson-Hughes B, Orav JE, Li R, Spiegelman D, et al. Dietary Calcium and Serum 25-Hydroxyvitamin D Status in Relation to BMD Among U.S. Adults. J Bone Miner Res. 2009;24(5):935-42. https://doi.org/10.1359/jbmr.081242

Cranney A, Horsley T, O’Donnell S, Weiler H, Puil L, Ooi D, et al. Effectiveness and safety of vitamin D in relation to bone health. Evid Rep Technol Assess (Full Rep). 2007;(158):1-235. Disponible en: https://pubmed.ncbi.nlm.nih.gov/18088161/

Bischoff-Ferrari HA, Willett WC, Orav EJ, Lips P, Meunier PJ, Lyons RA, et al. A Pooled Analysis of Vitamin D Dose Requirements for Fracture Prevention. New England Journal of Medicine. 2012;367(1):40-9. https://doi.org/10.1056/NEJMoa1109617

Weaver CM, Alexander DD, Boushey CJ, Dawson-Hughes B, Lappe JM, LeBoff MS, et al. Calcium plus vitamin D supplementation and risk of fractures: an updated meta-analysis from the National Osteoporosis Foundation. Osteoporos Int. 2016;27(1):367-76. https://doi.org/10.1007/s00198-015-3386-5

Reid IR, Bolland MJ, Grey A. Effects of vitamin D supplements on bone mineral density: a systematic review and meta-analysis. Lancet. 2014;383(9912):146-55. https://doi.org/10.1016/S0140-6736(13)61647-5

Moyer VA, U.S. Preventive Services Task Force*. Vitamin D and calcium supplementation to prevent fractures in adults: U.S. Preventive Services Task Force recommendation statement. Ann Intern Med. 2013;158(9):691-6. https://doi.org/10.7326/0003-4819-158-9-201305070-00603

US Preventive Services Task Force, Grossman DC, Curry SJ, Owens DK, Barry MJ, Caughey AB, et al. Interventions to Prevent Falls in Community-Dwelling Older Adults: US Preventive Services Task Force Recommendation Statement. JAMA. 2018;319(16):1696-704. https://doi.org/10.1001/jama.2018.3097

Bolland MJ, Grey A, Avenell A. Effects of vitamin D supplementation on musculoskeletal health: a systematic review, meta-analysis, and trial sequential analysis. The lancet Diabetes & endocrinology. 2018;6(11):847-58. https://doi.org/10.1016/S2213-8587(18)30265-1

Yao P, Bennett D, Mafham M, et al. Vitamin D and Calcium for the Prevention of Fracture: A Systematic Review and Meta-analysis. JAMA Netw Open. 2019;2(12):e1917789. https://doi.org/10.1001/jamanetworkopen.2019.17789

Thanapluetiwong S, Chewcharat A, Takkavatakarn K, Praditpornsilpa K, Eiam-Ong S, Susantitaphong P. Vitamin D supplement on prevention of fall and fracture. Medicine (Baltimore). 2020;99(34):1-12. https://doi.org/10.1097/MD.0000000000021506

Li S, Xi C, Li L, Long Z, Zhang N, Yin H, et al. Comparisons of different vitamin D supplementation for prevention of osteoporotic fractures: a Bayesian network meta-analysis and meta-regression of randomised controlled trials. Int J Food Sci Nutr. 2021;72(4):518-28. https://doi.org/10.1080/09637486.2020.1830264.

Pilz S, Verheyen N, Grübler MR, Tomaschitz A, März W. Vitamin D and cardiovascular disease prevention. Nature Reviews Cardiology. 2016;13(7):404-17. https://doi.org/10.1038/nrcardio.2016.73

Nudy M, Krakowski G, Ghahramani M, Ruzieh M, Foy AJ. Vitamin D supplementation, cardiac events and stroke: A systematic review and meta-regression analysis. Int J Cardiol Heart Vasc . 2020;28(2020):1-8. https://doi.org/10.1016/j.ijcha.2020.100537

Beveridge LA, Struthers AD, Khan F, Jorde R, Scragg R, Macdonald HM, et al. Effect of Vitamin D Supplementation on Blood Pressure: A Systematic Review and Meta-analysis Incorporating Individual Patient Data. JAMA Intern Med. 2015;175(5):745-54. https://doi.org/10.1001/jamainternmed.2015.0237

Zhang R, Li B, Gao X, Tian R, Pan Y, Jiang Y, et al. Serum 25-hydroxyvitamin D and the risk of cardiovascular disease: dose-response meta-analysis of prospective studies. Am J Clin Nutr. 2017;105(4):810-9. https://doi.org/10.3945/ajcn.116.140392

Brøndum-Jacobsen P, Benn M, Jensen GB, Nordestgaard BG. 25-hydroxyvitamin d levels and risk of ischemic heart disease, myocardial infarction, and early death: population-based study and meta-analyses of 18 and 17 studies. Arterioscler Thromb Vasc Biol. 2012;32(11):2794-802. https://doi.org/10.1161/ATVBAHA.112.248039

Zhou R, Wang M, Huang H, Li W, Hu Y, Wu T. Lower Vitamin D Status Is Associated with an Increased Risk of Ischemic Stroke: A Systematic Review and Meta-Analysis. Nutrients. 2018;10(3):1-12. https://doi.org/10.3390/nu10030277

Manson JE, Cook NR, Lee I-M, Christen W, Bassuk SS, Mora S, et al. Vitamin D Supplements and Prevention of Cancer and Cardiovascular Disease. N Engl J Med. 2019;380(1):33-44. https://doi.org/10.1056/NEJMoa1809944

Scragg R, Stewart AW, Waayer D, Lawes CMM, Toop L, Sluyter J, et al. Effect of Monthly High-Dose Vitamin D Supplementation on Cardiovascular Disease in the Vitamin D Assessment Study: A Randomized Clinical Trial. JAMA Cardiol. 2017;2(6):608-16. https://doi.org/10.1001/jamacardio.2017.0175

Golzarand M, Shab-Bidar S, Koochakpoor G, Speakman J R, Djafarian K. Effect of vitamin D3 supplementation on blood pressure in adults: An updated meta-analysis - Nutrition, Metabolism and Cardiovascular Diseases. 2016;26(8) 663-673. https://doi.org/10.1016/j.numecd.2016.04.011

Garland CF, Garland FC. Do sunlight and vitamin D reduce the likelihood of colon cancer? Int J Epidemiol. 1980;9(3):227-31. https://doi.org/10.1093/ije/9.3.227

Feldman D, Krishnan AV, Swami S, Giovannucci E, Feldman BJ. The role of vitamin D in reducing cancer risk and progression. Nat Rev Cancer. 2014;14(5):342-57. https://doi.org/10.1038/nrc3691

Lee JE, Li H, Chan AT, Hollis BW, Lee I-M, Stampfer MJ, et al. Circulating levels of vitamin D and colon and rectal cancer: the Physicians’ Health Study and a meta-analysis of prospective studies. Cancer Prev Res (Phila). 2011;4(5):735-43. https://doi.org/10.1158/1940-6207.CAPR-10-0289

Gandini S, Boniol M, Haukka J, Byrnes G, Cox B, Sneyd MJ, et al. Meta-analysis of observational studies of serum 25-hydroxyvitamin D levels and colorectal, breast and prostate cancer and colorectal adenoma. Int J Cancer. 2011;128(6):1414-24. https://doi.org/10.1002/ijc.25439

Han J, Guo X, Yu X, Liu S, Cui X, Zhang B, et al. 25-Hydroxyvitamin D and Total Cancer Incidence and Mortality: A Meta-Analysis of Prospective Cohort Studies. Nutrients. 2019;11(10). https://doi.org/10.3390/nu11102295

Goulão B, Stewart F, Ford JA, MacLennan G, Avenell A. Cancer and vitamin D supplementation: a systematic review and meta-analysis. The American Journal of Clinical Nutrition. 2018;107(4):652-63. https://doi.org/10.1093/ajcn/nqx047

Keum N, Giovannucci E. Vitamin D supplements and cancer incidence and mortality: a meta-analysis. Br J Cancer. 2014;111(5):976-80. https://doi.org/10.1038/bjc.2014.294

Wk M, Jl P, Aj R. Vitamin D supplementation in bipolar depression: A double blind placebo controlled trial. Journal of psychiatric research. 2017; 95: 48-53. https://doi.org/10.1016/j.jpsychires.2017.07.021

Menon V, Kar SK, Suthar N, Nebhinani N. Vitamin D and Depression: A Critical Appraisal of the Evidence and Future Directions. Indian journal of psychological medicine. 2020;42(1):11-21. https://doi.org/10.4103/IJPSYM.IJPSYM_160_19

Hansen JP, Pareek M, Hvolby A, Schmedes A, Toft T, Dahl E, et al. Vitamin D3 supplementation and treatment outcomes in patients with depression (D3-vit-dep). BMC Res Notes. 2019;12(1):1-6. https://doi.org/10.1186/s13104-019-4218-z

de Koning EJ, Lips P, Penninx BWJH, Elders PJM, Heijboer AC, den Heijer M, et al. Vitamin D supplementation for the prevention of depression and poor physical function in older persons: the D-Vitaal study, a randomized clinical trial. Am J Clin Nutr. 2019;110(5):1119-30. https://doi.org/10.1093/ajcn/nqz141

Spedding S. Vitamin D and depression: a systematic review and meta-analysis comparing studies with and without biological flaws. Nutrients. 2014;6(4):1501-18. https://doi.org/10.3390/nu6041501

Gowda U, Mutowo MP, Smith BJ, Wluka AE, Renzaho AMN. Vitamin D supplementation to reduce depression in adults: meta-analysis of randomized controlled trials. Nutrition. 2015;31(3):421-9. https://doi.org/10.1016/j.nut.2014.06.017

Vellekkatt F, Menon V. Efficacy of vitamin D supplementation in major depression: A meta-analysis of randomized controlled trials. J Postgrad Med. 2019;65(2):74-80.

Ziegler M, Wallert M, Lorkowski S, Peter K. Cardiovascular and Metabolic Protection by Vitamin E: A Matter of Treatment Strategy? Antioxidants (Basel). 2020;9(10). https://doi.org/10.3390/antiox9100935

Peh HY, Tan WSD, Liao W, Wong WSF. Vitamin E therapy beyond cancer: Tocopherol versus tocotrienol. Pharmacol Ther. 2016;162:152-69. https://doi.org/10.1016/j.pharmthera.2015.12.003

Wallert M, Börmel L, Lorkowski S. Inflammatory Diseases and Vitamin E-What Do We Know and Where Do We Go? Mol Nutr Food Res. 2021;65(1):e2000097. https://doi.org/10.1002/mnfr.202000097

Jafari T, Fallah AA, Reyhanian A, Sarmast E. Effects of pomegranate peel extract and vitamin E on the inflammatory status and endothelial function in hemodialysis patients: a randomized controlled clinical trial. Food Funct. 2020;11(9):7987-93. https://doi.org/10.1039/D0FO01012J

Okebukola PO, Kansra S, Barrett J. Vitamin E supplementation in people with cystic fibrosis. Cochrane Database Syst Rev. 2020;9:CD009422. https://doi.org/10.1002/14651858.CD009422.pub4

Anushiravani A, Haddadi N, Pourfarmanbar M, Mohammadkarimi V. Treatment options for nonalcoholic fatty liver disease: a double-blinded randomized placebo-controlled trial. Eur J Gastroenterol Hepatol. 2019;31(5):613-7. https://doi.org/10.1097/MEG.0000000000001369

Amanullah I, Khan YH, Anwar I, Gulzar A, Mallhi TH, Raja AA. Effect of vitamin E in non-alcoholic fatty liver disease: a systematic review and meta-analysis of randomised controlled trials. Postgrad Med J. 2019;95(1129):601-11. https://doi.org/10.1136/postgradmedj-2018-136364

Sozen E, Demirel T, Ozer NK. Vitamin E: Regulatory role in the cardiovascular system. IUBMB Life. 2019;71(4):507-15. https://doi.org/10.1002/iub.2020

Barzegar-Amini M, Ghazizadeh H, Seyedi SM reza, Sadeghnia HR, Mohammadi A, Hassanzade-Daloee M, et al. Serum vitamin E as a significant prognostic factor in patients with dyslipidemia disorders. Diabetes Metab Syndr Clin Res Rev. 2019;13(1):666-71. https://doi.org/10.1016/j.dsx.2018.11.034

Emami MR, Safabakhsh M, Alizadeh S, Asbaghi O, Khosroshahi MZ. Effect of vitamin E supplementation on blood pressure: a systematic review and meta-analysis. J Hum Hypertens. 2019;33(7):499-507. https://doi.org/10.1038/s41371-019-0192-0

Wong SK, Kamisah Y, Mohamed N, Muhammad N, Masbah N, Fahami NAM, et al. Potential Role of Tocotrienols on Non-Communicable Diseases: A Review of Current Evidence. Nutrients. 2020;12(1). https://doi.org/10.3390/nu12010259

Loffredo L, Perri L, Di Castelnuovo A, Iacoviello L, De Gaetano G, Violi F. Supplementation with vitamin E alone is associated with reduced myocardial infarction: A meta-analysis. Nutrition, Metabolism and Cardiovascular Diseases. 2015;25(4):354-63. https://doi.org/10.1016/j.numecd.2015.01.008

Bessell E, Jose MD, McKercher C. Associations of fish oil and vitamin B and E supplementation with cardiovascular outcomes and mortality in people receiving haemodialysis: a review. BMC Nephrol. 2015;16(1):1-8. https://doi.org/10.1186/s12882-015-0142-1

Ghosh N, Das A, Khanna S. Chapter 19 - Vitamin E: Tocopherols and tocotrienol and their role in health and disease. En: Prasad AS, Brewer GJ, editores. Essential and Toxic Trace Elements and Vitamins in Human Health [Internet]. Academic Press; 2020 [citado 15 de abril de 2021]. p. 283-93.

https://doi.org/10.1016/B978-0-12-805378-2.00020-6

Dysken MW, Sano M, Asthana S, Vertrees JE, Pallaki M, Llorente M, et al. Effect of vitamin E and memantine on functional decline in Alzheimer disease: the TEAM-AD VA cooperative randomized trial. JAMA. 2014;311(1):33-44. https://doi.org/10.1001/jama.2013.282834

Wang W, Li J, Zhang H, Wang X, Zhang X. Effects of vitamin E supplementation on the risk and progression of AD: a systematic review and meta-analysis. Nutr Neurosci. 2021;24(1):13-22. https://doi.org/10.1080/1028415X.2019.1585506

Zhu Y-J, Bo Y-C, Liu X-X, Qiu C-G. Association of dietary vitamin E intake with risk of lung cancer: a dose-response meta-analysis. Asia Pac J Clin Nutr.2017;26(2):271-7. https://doi.org/10.6133/apjcn.032016.04.

Yang CS, Luo P, Zeng Z, Wang H, Malafa M, Suh N. Vitamin E and cancer prevention: Studies with different forms of tocopherols and tocotrienols. Mol Carcinog. 2020;59(4):365-89. https://doi.org/10.1002/mc.23160

Leng Y, Zhou H, Meng F, Tian T, Xu J, Yan F. Association of vitamin E on the risk of ovarian cancer: a meta-analysis. Biosci Rep. 2019;39(12). https://doi.org/10.1042/BSR20193311

Constantinou C, Charalambous C, Kanakis D. Vitamin E and cancer: an update on the emerging role of γ and δ tocotrienols. Eur J Nutr. 2020;59(3):845-57. https://doi.org/10.1007/s00394-019-01962-1

Vitamina K | Sociedad Española de Dietética y Ciencias de la Alimentación (S.E.D.C.A.) [Internet]. [citado 16 de abril de 2021]. Disponible en: https://nutricion.org/portfolio-item/vitamina-k/

Melo V, Cuamatzi O. Bioquímica de los procesos metabólicos. Reverte; 2020. 480 p.

Wen L, Chen J, Duan L, Li S. Vitamin K‑dependent proteins involved in bone and cardiovascular health (Review). Mol Med Rep. 2018;18(1):3-15. https://doi.org/10.3892/mmr.2018.8940

Vlasschaert C, Goss CJ, Pilkey NG, McKeown S, Holden RM. Vitamin K Supplementation for the Prevention of Cardiovascular Disease: Where Is the Evidence? A Systematic Review of Controlled Trials. Nutrients. 2020;12(10):1-25. https://doi.org/10.3390/nu1210290975. Hartley L, Clar C, Ghannam O, Flowers N, Stranges S, Rees K. Vitamin K for the primary prevention of cardiovascular disease. Cochrane Database Syst Rev 2015;(9):1-25. https://doi.org/10.1002/14651858.CD011148.pub2

Cheung C-L, Sahni S, Cheung BMY, Sing C-W, Wong ICK. Vitamin K intake and mortality in people with chronic kidney disease from NHANES III. Clin Nutr. 2015;34(2):235-40. https://doi.org/10.1016/j.clnu.2014.03.011

Van Ballegooijen AJ, Beulens JW. The Role of Vitamin K Status in Cardiovascular Health: Evidence from Observational and Clinical Studies. Curr Nutr Rep. 2017;6(3):197-205. https://doi.org/10.1007/s13668-017-0208-8

Vermeer C, Theuwissen E. Vitamin K, osteoporosis and degenerative diseases of ageing. Menopause Int. 2011;17(1):19-23. https://doi.org/10.1258/mi.2011.011006

Palermo A, Tuccinardi D, D’Onofrio L, Watanabe M, Maggi D, Maurizi AR, et al. Vitamin K and osteoporosis: Myth or reality? Metabolism. 2017;70:57-71. https://doi.org/10.1016/j.metabol.2017.01.032

Fusaro M, Mereu MC, Aghi A, Iervasi G, Gallieni M. Vitamin K and bone. Clin Cases Miner Bone Metab. 2017;14(2):200-6. https://doi.org/10.11138/ccmbm/2017.14.1.200

Mott A, Bradley T, Wright K, Cockayne ES, Shearer MJ, Adamson J, et al. Effect of vitamin K on bone mineral density and fractures in adults: an updated systematic review and meta-analysis of randomised controlled trials. Osteoporos Int. 2019;30(8):1543-59. https://doi.org/10.1007/s00198-019-04949-0

Sim M, Lewis JR, Prince RL, Levinger I, Brennan-Speranza TC, Palmer C, et al. The effects of vitamin K-rich green leafy vegetables on bone metabolism: A 4-week randomised controlled trial in middle-aged and older individuals. Bone Rep. 2020;12:100274. https://doi.org/10.1016/j.bonr.2020.100274

Hamidi MS, Gajic-Veljanoski O, Cheung AM. Vitamin K and bone health. J Clin Densitom. 2013;16(4):409-13. https://doi.org/10.1016/j.jocd.2013.08.017

Díaz CM. Acción de la vitamina K sobre la salud ósea. Revista de Osteoporosis y Metabolismo Mineral. 2015;7(1):33-8. https://doi.org/10.4321/S1889-836X2015000100008

Shahdadian F, Mohammadi H, Rouhani MH. Effect of Vitamin K Supplementation on Glycemic Control: A Systematic Review and Meta-Analysis of Clinical Trials. Horm Metab Res. 2018;50(3):227-35. https://doi.org/10.1055/s-0044-100616

Schwalfenberg GK. Vitamins K1 and K2: The Emerging Group of Vitamins Required for Human Health. J Nutr Metab. 2017;2017:1-6. https://doi.org/10.1155/2017/6254836

Ho H-J, Komai M, Shirakawa H. Beneficial Effects of Vitamin K Status on Glycemic Regulation and Diabetes Mellitus: A Mini-Review. Nutrients. 2020;12(8):1-16. https://doi.org/10.3390/nu12082485

Li Y, Chen JP, Duan L, Li S. Effect of vitamin K2 on type 2 diabetes mellitus: A review. Diabetes Res Clin Pract. 2018;136:39-51. https://doi.org/10.1016/j.diabres.2017.11.020

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2022-02-11

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Giraldo Gallego, J. P., Arbeláez Marulanda, M. C., Jaramillo Yepes, F. A., Henao Roldán, C., & Muñoz Contreras, A. M. (2022). Función de las vitaminas D, E y K en condiciones especiales: salud y enfermedad. Perspectivas En Nutrición Humana, 24(1), 103–124. https://doi.org/10.17533/udea.penh.v24n1a07

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