Antiparasitic activity of methanol extracts and isolated fractions from caribbean sponges
DOI:
https://doi.org/10.17533/udea.vitae.395Keywords:
marine sponges, antiparasitic substances, Ircinia, Epidioxysterols, esponjas marinas, sustancias antiparasitarias, EpidioxiesterolesAbstract
Se evaluaron contra varios parásitos seleccionados los extractos metanólicos de ocho esponjas caribeñas (Clase Demospongía, Filo Porifera). Las esponjas estudiadas fueron Ircinia strobilina, Ircinia felix, Ircinia campana, Xestospongia proxima, Xestospongia muta, Agelas conifera, Agelas clathrodes y Niphates erecta. Los parásitos utilizados como bioindicadores fueron Trypanosoma brucei, Trypanosoma cruzi, Leishmania infantum, Leishmania panamensis Plasmodium falciparum Itg2 y Plasmodium falciparum Ghana. Los extractos más activos fueron los obtenidos de las esponjas Ircinia felix, Ircinia campana y Xestospongia proxima. Los fraccionamientos cromatográficos de los extractos metanólicos de las esponjas Ircinia felix e Ircinia campana, permitieron aislar varias fracciones, de las cuales las que mostraron mayor actividad contra amastigotes de Leishmania panamensis, contienen mezclas complejas de 5&8&-epidioxiesteroles, de acuerdo con los análisis por RMN-1H y HPLC. Por otro lado, la fracción más activa contra Plasmodium falciparum Itg2 fue una fracción obtenida del extracto del I. felix, la cual no mostró evidencia de la presencia de 5&8&-epidioxiesteroles ni de ácidos tetrónicos seterterpénicos.Downloads
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