EFFECTS OF THE FUNDAMENTAL PROPERTIES OF AMPICILLIN RAW MATERIAL IN THE DERIVATIVE PROPERTIES
DOI:
https://doi.org/10.17533/udea.vitae.566Keywords:
Ampicillin, fundamental properties, derivative properties, dissolution profiles, similarity factor, inhibiting minimum concentration.Abstract
Antimicrobial agents often generate doubts concerning their therapeutic effects; it is not infrequent
to find differences in the clinical effectiveness among products of the same active principle made by
different laboratories. It is, therefore, necessary to carry out studies as to the reasons of such variations
in order to reduce or eliminate differences in the therapeutic products. We evaluated the fundamental
characteristics (external form, internal structure, and physical and chemical identification) of ampicillin
powder using a trade name product (powder in capsules), a generic one (powder in capsules), as well as
different crystalline forms of the raw material (also in powder), obtained by recrystallization in different
solvents at room temperature. After determining the fundamental properties of the aforementioned
solids, they were compared on the basis of the results obtained in their derivative properties such as the
dissolution profiles analyzed by means of the difference and similarity factors (f1, f2), and the antimicrobial effectiveness indexes by means of the minimal inhibitory concentration (MIC).
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