EFFECTS OF THE FUNDAMENTAL PROPERTIES OF AMPICILLIN RAW MATERIAL IN THE DERIVATIVE PROPERTIES

Authors

  • Julie F. BENAVIDES A.
  • Esther J. IBARRA J.
  • Érica J. OBANDO M.
  • Juliana PÉREZ L.
  • Gloria E. TOBÓN Z.
  • Óscar A. FLÓREZ A.

DOI:

https://doi.org/10.17533/udea.vitae.566

Keywords:

Ampicillin, fundamental properties, derivative properties, dissolution profiles, similarity factor, inhibiting minimum concentration.

Abstract

Antimicrobial agents often generate doubts concerning their therapeutic effects; it is not infrequent

to find differences in the clinical effectiveness among products of the same active principle made by

different laboratories. It is, therefore, necessary to carry out studies as to the reasons of such variations

in order to reduce or eliminate differences in the therapeutic products. We evaluated the fundamental

characteristics (external form, internal structure, and physical and chemical identification) of ampicillin

powder using a trade name product (powder in capsules), a generic one (powder in capsules), as well as

different crystalline forms of the raw material (also in powder), obtained by recrystallization in different

solvents at room temperature. After determining the fundamental properties of the aforementioned

solids, they were compared on the basis of the results obtained in their derivative properties such as the

dissolution profiles analyzed by means of the difference and similarity factors (f1, f2), and the antimicrobial effectiveness indexes by means of the minimal inhibitory concentration (MIC).

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Published

04-02-2009

How to Cite

BENAVIDES A., J. F., IBARRA J., E. J., OBANDO M., Érica J., PÉREZ L., J., TOBÓN Z., G. E., & FLÓREZ A., Óscar A. (2009). EFFECTS OF THE FUNDAMENTAL PROPERTIES OF AMPICILLIN RAW MATERIAL IN THE DERIVATIVE PROPERTIES. Vitae, 14(1). https://doi.org/10.17533/udea.vitae.566

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