THE EFFECT OF THE SOLVENT RECRYSTALLIZATION AND PARTICLE SIZE ON WETTABILITY OF IBUPROFEN
DOI:
https://doi.org/10.17533/udea.vitae.1425Keywords:
wettability, ibuprofen, recristalization, crystal habit, particle size, contact angle.Abstract
The present work evaluates ibuprofen wettability recrystallized by the evaporation solvent method in
ethanol, methanol and hexane. Previously, an operational qualification of the gonyometer is realized by
means of the determination of the PTFE-water system wettability, finding good precision represented by
a variation coefficient of 2.49% (Total variability). It obtains crystalline prismatic habits for the ibuprofen
recrystallized in ethanol and methanol, and needle-shaped on having used hexane as solvent; moreover, in
the X-ray diffraction analysis to establish the internal structure the three products prove isomorphs. The
contact angle is determinated for the three forms recrystallized in three ranges of particle size, finding
that the minor value of contact angle or the best wettability is presented by ibuprofen recrystallized in
ethanol, with an average size of 120 µm, giving information of the most adequate shape type and size
particle in the formulation of the tablets of this substance.
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