Therapeutic Effects of the Genus Physalis L. (Solanaceae): A Review of the Literature
DOI:
https://doi.org/10.17533/udea.penh.v24n2a07Keywords:
Physalis L., Therapeutic Uses, Polyphenols, GoldenberryAbstract
Background: The Physalis L. genus is a berry type fruit, known as golden berry, aguaymanto, capulí, uvilla, cape gooseberry and has been used to treat some diseases. Objective: To review the scientific literature on the therapeutic effects of Physalis species: Physalis peruviana L., Physalis angulata L., Physalis ixocarpa L., and Physalis alkekengi var. franchetii L. Materials and Methods: A search was carried out in the bases of data Web of Science, Medline/PubMed, Scopus, ScienceDirect, with the keywords Physalis peruviana L, Physalis angulata L., Physalis alkekengi var. franchetii L., Physalis ixocarpa L. and clinical trials. Results: Were found 49 articles in the Web of Science database, 14 in Medline/PubMed, 968 in Scopus, and 129 in ScienceDirect. Of 1160 studies identified, only 32 were accepted studies for the research data. The articles demonstrate therapeutic effects of Physalis in in vivo studies. Conclusion: This review provides a comprehensive understanding of the therapeutic effects of the genus Physalis L, supported by a large body of scientific experiments. The therapeutic properties found were antihepatotoxic, antinephrotoxic, anticancer, antidiabetic, antineurotoxic, antioxidant, antineurodegenerative, antibacterial, analgesic, renoprotective, antiasthmatic, anticholesterolemic, diuretic, antihistamine, antiinflammatory, and antiulcer effects
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References
Organización Mundial de la Salud. OMS | Medicina tradicional. WHO [Internet]. 2010; Disponible en: https://www.who.int/ topics/traditional_medicine/definitions/es/
Newman DJ, Cragg, Gordon M. Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007;70(3):461‑77.https://doi.org/10.1021/np068054v
Jaberian H, Piri K, Nazari J. Phytochemical composition and in vitro antimicrobial and antioxidant activities of some medicinal plants. Food Chem. 2013;136(1):237-44. https://doi.org/10.1016/j.foodchem.2012.07.084
Akhtar N, Ihsan-ul-Haq, Mirza, Bushra. Phytochemical analysis and comprehensive evaluation of antimicrobial and antioxidant properties of 61 medicinal plant species. Arab J Chem. 2015;11(8):1223-35. https://doi.org/10.1016/j.arabjc.2015.01.013
Singh A, Duggal S, Singh H, Singh J, Katekhaye, Shankar. Withanolides: Phytoconstituents with significant pharmacological activities. Int J Green Pharm. 2010;4(4):229. https://doi.org/10.4103/0973-8258.74130
Zhang WN, Tong, Wang-Yu. Chemical constituents and biological activities of plants from the genus Physalis. Chem Biodivers. 2016;13(1):48-65. https://doi.org/10.1002/cbdv.201400435
Puente LA, Pinto-Muñoz CA, Castro ES, Cortés M. Physalis peruviana Linnaeus, the multiple properties of a highly functional fruit: A review. Food Res Int. 2011;44(7):1733-40. https://doi.org/10.1016/j.foodres.2010.09.034
Frida Susanti R, Kurnia K, Vania A, Jeremy Reynaldo I. Total Phenol, Flavanoid and Antioxidant Activity of Physalis angulata Leaves Extract by Subcritical Water Extraction. Mod Appl Sci. 2015;9(7):190. https://doi.org/10.5539/mas.v9n7p190
González-Mendoza D, Ascencio-Martinez D, Hau Poox A, Mendez-Trujillo V, Grimaldo-Juarez O, Santiaguillo Hernández JF, Cervantes Diaz L, Aviles Marin SM. Phenolic compounds and physiochemical analysis of Physalis ixocarpa genotypes. SciRes Essays. 2016;6(17):3808-14. https://doi.org/10.5897/SRE11.370
Qiu L, Zhao F, Liu H, Chen L, Jiang Z, Liu H, et al. Two new megastigmane glycosides, physanosides A and B, from Physalis alkekengi L. var. franchetii, and their effect on NO release in macrophages. Chem Biodivers. 2008;5(5):758-63. https://doi.org/10.1002/cbdv.200890072
Lima CSM, Severo J, de Andrade SB, Affonso LB, Rombaldi CV, Rufato ADR. Qualidade pós-colheita de Physalis sob temperatura ambiente e refrigeração. Rev Ceres. 2013;60(3):311-7. https://doi.org/10.1590/S0034-737X2013000300002
Dkhil MA, Al-Quraishy S, Diab MMS, Othman MS, Aref AM, Moneim AEA. The potential protective role of Physalis peruviana L. fruit in cadmium-induced hepatotoxicity and nephrotoxicity. Food Chem Toxicol. 2014;74:98-106. https://doi.org/10.1016/j.fct.2014.09.013
Ahmed LA. Renoprotective effect of Egyptian cape gooseberry fruit (Physalis peruviana L.) against acute renal injury in rats. SciWorld J. 2014. https://doi.org/10.1155/2014/273870
Usos Terapéuticos-MeSH-NCBI [Internet]. [cited 2019 Apr 12]. Available from: https://www.ncbi.nlm.nih.gov/mesh/term=therapeutic+uses
Da Silva BJM, Pereira SWG, Rodrigues APD, Do Nascimento JLM, Silva EO. In vitro antileishmanial effects of Physalis angulata root extract on Leishmania infantum. J Integr Med. 2018;16(6):404-10. https://doi.org/10.1016/j.joim.2018.08.004
Wang Y, Wang S lou, Zhang J yi, Song X ning, Zhang Z yong, Li J feng, et al. Anti-ulcer and anti-Helicobacter pylori potentials of the ethyl acetate fraction of Physalis alkekengi L. var. franchetii (Solanaceae) in rodent. J Ethnopharmacol. 2018;211:197-206. https://doi.org/10.1016/j.jep.2017.09.004
Medina JR, Aviña GN. Revisión de flavonoides identificados en el género Physalis (Solanaceae), su capacidad antioxidante e importancia como marcadores químicos . Flavonoids identified from Physalis gender (Solanaceae), its antioxidant capacity and importance as chemical m. Nat y Desarro. 2014;12(June):16-27.
Liang L, Li C, Wang Y, Yue Y, Zhang H, Yang M, Cao X, Zhao M, Du J, Pemg M, Chen Y, Li W, Xia T, Zhong R, Shu Z. Physalis alkekengi L var. franchhetti Makino: A review of the pharmacognosy, chemical constituents, pharmacological effects, quality control, and applications. Phytomedicine. 2022;105:154328. https://doi.org/10.1016/j.phymed.2022.154328
Whitson M, Manos PS. Untangling Physalis (Solanaceae) from the Physaloids: A Two-Gene Phylogeny of the Physalinae. Syst Bot. 2005;30(1):216-30. https://doi.org/10.1600/0363644053661841
Feng S, Jiang M, Shi Y, Jiao K, Shen C, Lu J, et al. Application of the Ribosomal DNA ITS2 Region of Physalis (Solanaceae): DNA Barcoding and Phylogenetic Study. Front Plant Sci. 2016;7. https://doi.org/10.3389/fpls.2016.01047
Wu J, Zhao J, Zhang T, Gu Y, Khan IA, Zou Z. Naturally occurring physalins from the genusv Physalis: A review. Phytochemistry. 2021;191:112925. https://doi.org/10.1016/j.phytochem.2021.112925
Zhao X, Chen Z, Yin Y, Li X. Effects of polysaccharide from physalis alkekengi var. Franchetii on liver injury and intestinal microflora in type-2 diabetic mice. Pharm Biol. 2017;55(1):2020–5. https://doi.org/10.1080/13880209.2017.1345953
Taj D, Khan H, Sultana V, Ara J, Ehteshamul-Haque S. Antihepatotoxic effect of golden berry (Physalis peruviana Linn.) in carbon tetrachloride (CCl4) intoxicated rats. Pak J Pharm Sci. 2014;27(3):491-4.
Arun M, Asha V V. Preliminary studies on antihepatotoxic effect of Physalis peruviana Linn. (Solanaceae) against carbon tetrachloride induced acute liver injury in rats. J Ethnopharmacol. 2007;111(1):110-4. https://doi.org/10.1016/j.jep.2006.10.038
Esmailpoor A, Ghasemian A, Dehnavi E, Peidayesh H, Teimouri M. Physalis alkekengi hydroalcoholic extract enhances the apoptosis in mouse model of breast cancer cells. Gene Reports. 2019;15:100366. https://doi.org/10.1016/j.genrep.2019.100366
El-Kenawy AEM, Elshama SS, Osman HEH. Effects of Physalis peruviana L on toxicity and lung cancer induction by nicotine derived nitrosamine ketone in rats. Asian Pacific J Cancer Prev. 2015;16(14):5863-8. https://doi.org/10.7314/APJCP.2015.16.14.5863
Erman F, Kirecci OA, Ozsahin AD, Erman O, Kaya T, Yilmaz O. Effects of Physalis peruviana and Lupinus albus on malondialdehyde, glutathione, cholesterol, vitamins and fatty acid levels in kidney and liver tissues of diabetic rats. Prog Nutr.2018;20:218-30. https://doi.org/10.23751/pn.v20i1-S.5669
Guo Y, Li S, Li J, Ren Z, Chen F, Wang X. Anti-hyperglycemic activity of polysaccharides from calyx of Physalis alkekengi var. franchetii Makino on alloxan-induced mice. Int J Biol Macromol. 2017;99:249-57. https://doi.org/10.1016/j.ijbiomac.2017.02.086
Kasali FM, Kadima JN, Mpiana PT, Ngbolua K te N, Tshibangu DST. Assessment of antidiabetic activity and acute toxicity of leaf extracts from Physalis peruviana L. in guinea-pig. Asian Pac J Trop Biomed. 2013;3(11):841-6. https://doi.org/10.1016/S2221-1691(13)60166-5
Javdan N. The effects of hydroalcoholic extract of Physalis alkekegi in alloxan -induced diabetic rats. Pharmacologyonline. 2011;878:874-8. https://pharmacologyonline.silae.it/files/archives/2011/vol2/088.jasem.pdf
Tong H, Liang Z, Wang G. Structural characterization and hypoglycemic activity of a polysaccharide isolated from the fruit of Physalis alkekengi L. Carbohydr Polym. 2008;71(2):316-23. https://doi.org/10.1016/j.carbpol.2007.06.001
Abdel-Moneim AE, Bauomy AA, Diab MMS, Shata MTM, Al-Olayan EM, El-Khadragy MF. The protective effect of Physalis peruviana L. against cadmium-induced neurotoxicity in rats. Biol Trace Elem Res. 2014;160(3):392-9. https://doi.org/10.1016/j.fct.2014.09.013
Wu S-J, Ng L-T, Huang Y-M, Lin D-L, Wang S-S, Huang S-N, et al. Antioxidant Activities of Physalis peruviana. Biol Pharm Bull. 2005;28(6):963-6. https://doi.org/10.1248/bpb.28.963
Moniruzzaman M, Chin YW, Cho J. HO-1 dependent antioxidant effects of ethyl acetate fraction from Physalis alkekengi fruit ameliorates scopolamine-induced cognitive impairments. Cell Stress Chaperones. 2018;23(4):763-72. https://doi.org/10.1007/s12192-018-0887-0
Shu Z, Xing N, Wang Q, Li X, Xu B, Li Z, et al. Antibacterial and Anti-Inflammatory Activities of Physalis Alkekengi var. franchetii and Its Main Constituents . Evidence-Based Complement Altern Med. 2016;2016:1-10. https://doi.org/10.1155/2016/4359394
Da Silva Lima M, Evangelista A, Dos Santos G, Ribeiro M, Tomassini T, Pereira Soares M, et al. Antinociceptive properties of physalins from physalis angulata. J Nat Prod. 2014;77(11):2397-403. https://doi.org/10.1021/np5003093
Bastos GNT, Santos ARS, Ferreira VMM, Costa AMR, Bispo CI, Silveira AJA, et al. Antinociceptive effect of the aqueous extract obtained from roots of Physalis angulata L. on mice. J Ethnopharmacol. 2006;103(2):241-5. https://doi.org/10.1016/j.jep.2005.08.008
Park HA, Kwon OK, Ryu HW, Min JH, Park MW, Park MH, et al. Physalis peruviana L. Inhibits ovalbumin-induced airway inflammation by attenuating the activation of NF-?B and inflammatory molecules. Int J Mol Med. 2019;43(4):1830-8. https://doi.org/10.3892/ijmm.2019.4110
Hong JM, Kwon OK, Shin IS, Song HH, Shin NR, Jeon CM, et al. Anti-inflammatory activities of Physalis alkekengi var. franchetii extract through the inhibition of MMP-9 and AP-1 activation. Immunobiology. 2015;220:1-9. https://doi.org/10.1016/j.imbio.2014.10.004
Othman MS, Nada A, Zaki HS, Abdel Moneim AE. Effect of Physalis peruviana L. on cadmium-induced testicular toxicity in rats. Biol Trace Elem Res. 2014;159(1-3):278-87. https://doi.org/10.1007/s12011-014-9955-1
Ramadan MF, Hassan NA, Elsanhoty RM, Sitohy MZ. Goldenberry (Physalis peruviana) juice rich in health-beneficial compounds suppresses high-cholesterol diet-induced hypercholesterolemia in Rats. J Food Biochem. 2013;37(6):708-22. https:// doi.org/10.1007/s12011-014-9955-1
Nanumala SK, Gunda K, Runja C, Sriram Chandra M. Evaluations of diuretic activity of methanolic extract of Physalis angulata L. leaves. Int J Pharm Sci Rev Res. 2012;16(2):40-2.
Rathore C, Dutt KR, Sahu S, Deb L. Antiasthmatic activity of the methanolic extract of. J Med Plants Res. 2011;5(22):5351-5.
Beiraghdar F, Einollahi B, Ghadyani A, Panahi Y, Hadjiakhoondi A, Vazirian M, et al. A two-week, double-blind, placebo-controlled trial of Viola odorata, Echium amoenum and Physalis alkekengi mixture in symptomatic benign prostate hyperplasia (BPH) men. Pharm Biol. 2017;55(1):1800-5. https://doi.org/10.1080/13880209.2017.1328445
Almeida LD, Quaglio AEV, De Almeida Costa CAR, Di Stasi LC. Intestinal anti-inflammatory activity of Ground Cherry (Physalis angulata L.) standardized CO2 phytopharmaceutical preparation. World J Gastroenterol. 2017;23(24):4369-80. https://doi.org/10.3748/wjg.v23.i24.4369
Yang YJ, Yi L, Wang Q, Xie BB, Dong Y, Sha CW. Anti-inflammatory effects of physalin E from Physalis angulata on lipopolysaccharide-stimulated RAW 264.7 cells through inhibition of NF-κB pathway. Immunopharmacol Immunotoxicol. 2017;39(2):74-9. https://doi.org/10.1080/08923973.2017.1282514
Castro J, Ocampo Y, Franco L. Cape Gooseberry [Physalis peruviana L.] Los cálices mejoran la colitis inducida por ácido TNBS en ratas. 2015.
Bastos GNT, Silveira AJA, Salgado CG, Picanço-Diniz DLW, do Nascimento JLM. Physalis angulata extract exerts anti-inflammatory effects in rats by inhibiting different pathways. J Ethnopharmacol. 2008;118(2):246-51. https://doi.org/10.1016/j.jep.2008.04.005
Franco LA, Matiz GE, Calle J, Pinzón R, Ospina LF. Actividad antinflamatoria de extractos y fracciones obtenidas de cálices de Physalis peruviana L. Biomédica. 2014;27(1):110. https://doi.org/10.7705/biomedica.v27i1.237
Nanumala SK, Kannadhasan R, Gunda K, Sivakumar G, Somasekhar P. Anti ulcer activity of the ethanolic extract of leaves Physalis angulata.l. Int J Pharm Pharm Sci. 2012;4(SUPPL. 4):226-8.
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