Acute oral toxicity from afFraction rich in phenolic compounds from the leaf extract of Swietenia macrophylla king in a murine model
Background: The mahogany tree (Swietenia macrophylla King) is widely used in traditional medicine, especially its seeds, which are used in Malaysia, Indonesia and some countries of South America. Recently an active fraction of the leaf ethanolic extract (labelled “Sm13-16,23”), showed promising results against some toxins of South American pit vipers. Objective: In this study the aim was to evaluate the acute oral toxicity of fraction Sm13-16,23 from the leaf ethanolic extract, using Swiss Webster mice. Materials and Methods: Fraction Sm13-16,23 was administered orally in a single dose to 2000 mg/kg and 300 mg/kg, clinical follow-up for 14 days was performed and then euthanasia, necropsy and histopathology of organs were performed. Results: Overall, there were not deaths recorded during the study period. Further not signs of toxicity in doses of 300mg/Kg were observed, but at doses of 2000 mg/kg, histopathological lesions in the liver, as karyomegaly and the binucleation were observed. Conclusion: Fraction Sm13-16,23 does not produce toxicity lesion at doses of 300mg/kg, indicating that the acute oral toxicity risk is low.
Brown N, Jennings S, Clements T. The ecology, silviculture and biogeography of mahogany (Swietenia macrophylla): a review of the evidence. Perspect. Plant Ecol. Evol. Syst. 2003; 6(1-2): 37 - 49.
Moghadamtousi SZ, Goh BH, Chan CK, Shabab T, Kadir HA. Biological activities and phytochemicals of Swietenia macrophylla King. Molecules. 2013; 18(9): 10465 - 10483.
Maiti A, Dewanjee S, Kundu M, Mandal SC. Protective effect of methanol extract of Swietenia macrophylla seeds on oxidative states associated with streptozotosin induced diabetic rats. Nat. Prod. Sci. 2007; 13(4): 295 - 299.
Maiti A, Dewanjee S, Mandal SC. In vivo evaluation of antidiarrhoeal activity of the seeds of Swietenia macrophylla King (Meliaceae). Trop. J Pharm. Res. 2007; 6: 711-716.
Maiti A, Dewanjee S, Subhash CM, Annadurai S. Exploration of antimicrobial potential of methanol and water extract of seeds of Swietenia macrophylla (Family: Meliaceae). Iranian J Pharmacol. Ther. 2007; 6(2): 99-102.
Balijepalli MK, Suppaiah V, Chin A, Buru AS, Sagineedu SR, Pichika MR. Acute oral toxicity studies of Swietenia macrophylla seeds in Sprague Dawley rats. Pharmacognosy Res. 2015; 7(1): 38-44. doi:10.4103/0974-8490.147197.
Cheng YB, Chien YT, Lee JC, Tseng CK, Wang HC, Lo IW, et al. Limonoids from the Seeds of Swietenia macrophylla with Inhibitory Activity against Dengue Virus 2. J Nat. Prod. 2014; 77(11): 2367-2374.
Mootoo BS, Ali A, Motilal R, Pingal R, Ramlal A, Khan A, et al. Limonoids from Swietenia macrophylla and S. aubrevilleana. J Nat. Prod. 1999; 62(11): 1514-1517.
Falah S, Suzuki T, Katayama T. Chemical constituents from Swietenia macrophylla and their antioxidant activity. Pak. J Biol. Sci. 2008; 11(16): 2007-2012.
Tan SK, Osman H, Wong KC, Boey PL. New phragmalin-type limonoids from Swietenia macrophylla King. Food Chem. 2009; 115(4): 1279-1285.
El Zalabani SM, El-Askary HI, Mousa OM, Issa MY, Zaitoun AA, Abdel-Sattar E. Acaricidal activity of Swietenia mahogani and Swietenia macrophylla ethanolic extracts against Varroa destructorin honeybee colonies. Exp. Parasitol. 2012; 130(2): 166-170.
Pereañez A, Núñez V, Patiño AC, Londoño M, Quintana JC. Inhibitory effects of plant phenolic compounds on enzymatic and cytotoxic activities induced by a snake venom phospholipase A2. Vitae. 2011; 18(3): 295-304.
Pereañez A, Lobo-Echeverri T, Rojano B, Vargas L, Fernández M, Gaviria CA, et al. Correlation of the inhibitory activity of phospholipase A2 snake venom and the antioxidant activity of Colombian plant extracts. Braz. J. Pharmacog. 2010; 20(6): 910-916.
Bhattacherjee P, Bhattacherjee D. Characterization of the aqueous extract of the root of Aristolochia indica: evaluation of its traditional use as an antidote for snake bites. J Ethnopharmacology .2013; 145(1): 220-6.
Patiño AC, López J, Aristizábal M, Quintana JC, Benjumea D. Evaluation of the inhibitory effect of extracts from leaves of Renealmia alpinia Rottb. Maas (Zingiberaceae) on the venom of Bothrops asper (mapana). Biomedica. 2012; 32(3): 365-74.
Phaopongthai J, Noiphrom J, Phaopongthai S, Pakmanee N, Sichaem J. Biological activities of Peristrophe bivalvis extracts: promising potential for anti-snake venoms against Naja Kaoutiaand Trimeresurus albovenoms. Nat Prod Res. 2016; 30(6): 697-9.
Naveen YP, Divya Rupini G, Ahmed F, Urooj A. Pharmacological effects and active phytoconstituents of Swietenia mahagoni: a review. J Integr. Med. 2014; 12(2): 86-93.
Percy DH, Barthold SW. Pathology of laboratory rodents and rabbits 3th ed. Iowa, USA: Blackwell Publishing; 2007. 325 p.
Maxie MG, Jubb KVF, Kennedy PC, Palmer N. Jubb, Kennedy and Palmer´s Pathology of Domestic Animals 5th ed Vol 2. St Louis, USA: Elsevier Saunders; 2016. 654 p.
Preciado L, Lobo-Echeverri T, Pereañez JA, Zapata K and Rojano B. Antioxidants from three Swietenia Species (Meliaceae). Journal of Medicinal Plants Research. 2016; 10(2): 8-17.
Pamplona S, Sá P, Lopes D, Costa E, Yamada, Silva C. In Vitro Cytoprotective Effects and Antioxidant Capacity of Phenolic Compounds from the Leaves of Swietenia macrophylla. Molecules 2015; 20(10): 18777-88.
Takami S, Imai T, Hasumura M, Cho YM, Onose J, Hirose M. Evaluation of toxicity of green tea catechins with 90-day dietary administration to F344 rats. Food and Chemical Toxicology. 2008; 46(6): 2222-24.
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