Modulación de la expresión génica por vitaminas liposolubles

  • Claudia María Velásquez Rodríguez Universidad de Antioquia
Palabras clave: vitaminas liposolubles, modulación génica, vitamina A, vitamina D, vitamina E, vitamina K, genética

Resumen

La mayoría de las células especializadas de los organismos multicelulares son capaces de alterar el patrón de su expresión génica en respuesta a señales extracelulares. Los nutrientes no solo sirven como componentes estructurales del cuerpo y como sustratos metabólicos, también actúan como reguladores de la expresión de genes, cuyos productos son componentes celulares. Muchos macro y micronutrientes pueden modular la trascripción y entre ellos las vitaminas liposolubles son las más estudiadas, especialmente los mecanismos moduladores por medio de los cuales ejercen esta acción. El enfoque de este artículo es sobre el papel delas vitaminas liposolubles: A, D, E y K en la modulación de la expresión génica.
|Resumen
= 3269 veces | PDF
= 232 veces|

Descargas

La descarga de datos todavía no está disponible.

Biografía del autor/a

Claudia María Velásquez Rodríguez, Universidad de Antioquia
Nutricionista Dietista. Mg Ciencias Básicas Biomédicas. Integrante Grupo de Investigación en Alimentación y Nutrición Humana, categoría A en Colciencias. Docente Escuela de Nutrición y Dietética Universidad de Antioquia.

Citas

Berdanier, C. Nutrient-gene interactions. Nutr Today. 2000;35:8-17.

Vernon Y. Good nutrition for all: challenge for the nutritional sciences in the new millennium. Nutr Today. 2001;6:6-16.

Luong KV, Nguyen LT. Vitamin D and cardiovascular disease. Curr Med Chem. 2006;13:2443-7.

Krause W. Skin diseases in consequence of endocrine alterations. Aging Male. 2006;9:81-95.

Eelen G, Verlinden L, De Clercq P, Vandewalle M, Bouillon R, Verstuyf A. Vitamin D analogs and coactivators. Anticancer Res. 2006;26:2717-21.

Taketani Y, Yamamoto H, Takeda E, Miyamoto K. Vitamin D and phosphate metabolism;relationship with aging-regulating gene. Clin Calcium. 2006;16:53-8.

Campbell SE, Stone WL, Lee S, Whaley S, Yang H, Qui M, et al. Comparative effects of RRR-alpha and RRR gamma-tocopherol on proliferation and apoptosis in human colon cancer cell lines. BMC Cancer. 2006;17:6-13.

Doraiswamy PM, Xiong GL. Pharmacological strategies for the prevention of Alzheimer’s disease. Expert Opin Pharmacother.2006;7:1-10.

Kamali F, Pirmohamed M. The future prospects of pharmacogenetics in oral anticoagulation therapy. Br J Clin Pharmacol. 2006;61:746-51.

Norman HA, Go VL, Butrum RR. Review of the International Research Conference on Food, Nutrition, and Cancer. J Nutr.2004;134):3391S-3S.

Gohil K. Functional genomics identifies novel and diverse molecular targets of nutrients in vivo. Biol Chem. 2004;385:691-6.

Ross, C. Vitamin A and carotenoids. In: modern nutrition in health and disease. Shils M, Shike M. 10 ed. Philadelphia: Lippincott Williams & Wilkins; 2006;p.351-75.

Li G, Yin W, Chamberlain R, Hewett-Emmett D, Roberts JN, Yang X, et al. Identification and characterization of the human retinoid X receptor alpha gene promoter. Gene. 2006;372:118-27.

Calleja C, Messaddeq N, Chapellier B, Yang H, Krezel W, Li M, et al. Genetic and pharmacological evidence that a retinoic acid cannot be the RXR-activating ligand in mouse epidermis keratinocytes. Genes Dev. 2006;20:1525-38.

Blomhoff R, Blomhoff HK. Overview of retinoid metabolism and function. J Neurobiol. 2006;66:606-30.

Smith S, Lee M, Thomas WD, Kavallaris M, Norris M, Haber M, et al. The estrogen-responsive B box protein is a novel regulator of the retinoid signal. J Biol Chem. 2006;281:18246-56.

Soprano DR, Soprano K. Role of RARs and RXRs in mediating the molecular mechanism of action of vitamin A. In: Zempleni J, Daniel H. Molecular nutrition. London: CABI Publishing; 2003;p.135-50.

Bourel M, Ardaillou R. Pharmacogenetics and pharmacogenomics. Bull Acad Natl Med. 2006;190:9-22.

McCaffery P, Andreola F, Giandomenico V, De Luca L. Vitamin A and gene expresión. In: Moustaid-Moussa N, Berdanier C. Nutrient-Gene interactions in health and disease. Washington: CRC Press; 2001;p. 286-319.

Tighe AP, Talmage DA. Retinoids arrest breast cancer cell proliferation: retinoic acid selectively reduces the duration of receptor tyrosine kinase signaling. Exp Cell Res. 2004;301:147-57.

Mrass P, Rendl M, Mildner M, Gruber F, Lengauer B, Ballaun C, et al. Retinoic acid increases the expression of p53 and proapoptotic caspases and sensitizes keratinocytes to apoptosis: a possible explanation for tumor preventive action of retinoids.Cancer Res. 2004;64:6542-8.

Crowe DL, Chandraratna RA. A retinoid X receptor (RXR)-selective retinoid reveals that RXR-alpha is potentially a therapeutic target in breast cancer cell lines, and that it potentiates antiproliferative and apoptotic responses to peroxisome proliferator-activated receptor ligands. Breast Cancer Res. 2004;6:R546-55.

Holick M. Vitamin D. In: modern nutrition in health and disease. Shils M, Shike M. 10 ed. Philadelphia: Lippincott Williams & Wilkins; 2006;p. 376-95.

Vupputuri MR, Goswami R, Gupta N, Ray D, Tandon N, Kumar N. Prevalence and functional significance of 25-hydroxyvitamin D deficiency and vitamin D receptor gene polymorphisms in Asian Indians. Am J Clin Nutr. 2006;83:1411-9.

Terpstra L, Knol DL, Van Coeverden SC, Delemarre-van de Waal HA. Bone metabolism markers predict increase in bone mass, height and sitting height during puberty depending on the VDR Fok1 genotype. Clin Endocrinol. 2006;64:625-31.

Jones G, Strugnell SA, DeLuca H. Current understanding of the molecular actions of vitamin D. Physiol Rev. 1998;78:1193-1231.

DeLuca HF. Overview of general physiologic features and functions of vitamin D. Am J Clin Nutr. 2004;80:1689S-96S.

Thijssen JH. Gene polymorphisms involved in the regulation of bone quality. Gynecol Endocrinol. 2006;22:131-9.

Cusack S, Molgaard C, Michaelsen KF, Jakobsen J, Lamberg-Allardt CJ, Cashman KD. Vitamin D and estrogen receptor-alpha genotype and indices of bone mass and bone turnover in Danish girls. J Bone Miner Metab. 2006;24:329-36.

Leathers VL, Linse S, Forsen S, Norman AW. Calbindin D28K, a 1α,25-dihydroxyvitamin D3-induced calcium-binding protein, binds five or six Ca2+ ions with high affinity. J Biol Chem. 1990;265:2784-7.

Cantorna MT, Zhu Y, Froicu M, Wittke A. Vitamin D status, 1,25-ihydroxyvitamin D3, and the immune system. Am J Clin Nutr. 2004;80:1717S-20S.

Harnett MM, Goodridge HS. Crecimiento celular, diferenciación y cáncer. En: Baynes JW, Dominiczac MH. Bioquímica médica. 2 ed. Madrid: Elsevier; 2006;p. 593-602.

Welsh J. Vitamin D and breast cancer: insights from animal models. Am J Clin Nutr. 2004;80:1721S-4S.

Bikle DD. Vitamin D and skin cancer. J Nutr. 2004;134:3472S-8S.

Peehl DM, Shinghal R, Nonn L, Seto E, Krishnan AV, Brooks JD, et al. Molecular activity of 1,25 dihydroxyvitamin D3 in primary cultures of human prostatic epithelial cells revealed by cADN microarray analysis. J Steroid Biochem Mol Biol. 2004;92:131-41.

Jiang F, Bao J, Li P, Nicosia SV, Bai W. Induction of ovarian cancer cell apoptosis by 1,25-dihydroxyvitamin D3 through the downregulation of telomerase. J Biol Chem. 2004;279:53213-21.

Norman AW, Collins ED. Vitamin D and gene expression. In: Moustaid-Moussa N, Berdanier C. Nutrient-Gene interactions in health and disease. Washington: CRC Press; 2001;p. 349-92.

Traber M. Vitamin E. En: modern nutrition in health and disease. Shils M, Shike M. 10 ed. Philadelphia: Lippincott Williams & Wilkins; 2006;p.396-411.

Gropper S, Smith J, Groff J. The fat-soluble vitamins. In: advanced nutrition and human metabolism. 4 ed. New York: Thompson Wadsworth, 2005;p. 325-68.

Halliwell B, Rafter J, Jenner A. Health promotion by flavonoids, tocopherols, tocotrienols, and other phenols: direct or indirect effects? Antioxidant or not?

Am J Clin Nutr. 2005;81:268S-76S.

Azzi A, Gysin R, Kempna P, Munteanu A, Villacorta L, Visarius T, et al. Regulation of gene expression by alpha-tocopherol. Biol Chem. 2004;385:585-91.

Meydani SN, Claycombe KJ. Vitamin E and gene expression. In: Moustaid-Moussa N, Berdanier C. Nutrient-Gene interactions in health and disease. Washington: CRC Press; 2001; p. 393-424.

Gimeno A, Zaragoza R, Vina JR, Miralles VJ. Vitamin E activates CRABP-II gene expression in cultured human fibroblasts, role of protein kinase C. FEBS Lett. 2004;569:240-4.

Baynes JW. Oxigeno y vida. En: Bioquímica médica. Baynes JW, Dominiczac MH. 2 ed. Madrid: Elsevier; 2006; p. 504-10.46. Mardla V, Kobzar G, Samel N. Potentiation of antiaggregating effect of prostaglandins by alpha-tocopherol and quercetin. Platelets.2004;15:319-24.

Suttie J. Vitamin K. In: modern nutrition in health and disease. Shils M, Shike M. 10 ed. Philadelphia: Lippincott Williams & Wilkins; 2006;p. 412-25.

Ryan-Harshman M, Aldoori W. Bone health. New role for vitamin K? Can Fam Physician. 2004;50:993-7.

Booth SL, Broe KE, Peterson JW, Cheng DM, Dawson-Hughes B, Gundberg CM, et al. Associations between vitamin K biochemical measures and bone mineral density in men and women. J Clin Endocrinol Metab. 2004;89:4904-9.

Kalkwarf HJ, Khoury JC, Bean J, Elliot JG. Vitamin K, bone turnover, and bone mass in girls. Am J Clin Nutr. 2004;80:1075-80.

Ishida Y, Kawai S. Comparative efficacy of hormone replacement therapy, etidronate, calcitonin, alfacalcidol, and vitamin K in postmenopausal women with osteoporosis: the Yamaguchi Osteoporosis Prevention Study. Am J Med. 2004;117:549-55.

Iwamoto J, Takeda T, Sato Y. Effects of vitamin K2 on osteoporosis. Curr Pharm Des. 2004;10:2557-76.

Publicado
2013-12-08
Cómo citar
Velásquez Rodríguez, C. M. (2013). Modulación de la expresión génica por vitaminas liposolubles. Perspectivas En Nutrición Humana, (16), 43-52. Recuperado a partir de https://revistas.udea.edu.co/index.php/nutricion/article/view/17867
Sección
Artículos de Revisión