Dyslipidemia in children with acute malnutrition. Turbo, Colombia
DOI:
https://doi.org/10.17533/udea.penh.16486Keywords:
dyslipidemias, nutritional marasmus, malnutrition, kwashiorkor, lipoproteins, children, ColombiaAbstract
Objective: to compare the lipid profile between preschools with and without acute malnutrition. Methods: a crosssectional study was developed in 43 preschools; 26 with and 17 without acute malnutrition. Malnutrition was assessedby weight for height ratio (P/T). Among the study groups, serum levels of TC, c-LDL, c-HDL and TG were compared. Results: the malnourished group showed a significantly higher frequency of c-HDL levels classified as lower comparedwith controls (19 vs 7%, respectively, p = 0.036) and a 1.8 times higher risk of c-HDL levels classified as lower(OR = 1,8; CI 0,96-3,28). TG levels were higher in malnourished children, but no significantly different from controls.TC, c-LDL, and c-HDL concentrations decreased significantly when acute malnutrition increased, while TG increasedbut not significantly. Arterial index TG/cHDL in children with severe acute malnutrition was significantly higher than inthe control group and the moderated malnourish children. Children with kwashiorkor had the lowest concentrationsof TC, cLDL, and cHDL and the highest TG and arterial index levels. Conclusions: preschool children affected bysevere acute malnutrition, especially kwashiorkor, have lower HDL-C concentrations, higher TG, and a high indexwhich exposed them to develop atherosclerosis.
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References
Unicef. Estado mundial de la infancia 2008: supervivencia infantil. New York: Unicef; 2007.
WHO Multicentre Growth Reference Study Group. WHO child growth standards: length/height-for-age, weight-for-age, weight-for-length, weight-for-height and body mass index-for-age: methods and development. Geneva: WHO; 2006.
Kerac M, Egan R, Mayer S, Walsh A, Seal A. New WHO growth standards: roll-out needs more resources. Lancet. 2009;374:100-2.
Dale NM, Grais RF, Minetti A, Miettola J, Barengo NC. Comparison of the new World Health Organization growth standards and the National Center for Health Statistics growth reference regarding mortality of malnourished children treated in a 2006 nutrition program in Niger. Arch Pediatr Adolesc Med. 2009;163:126-30.
OPS/OMS. Estrategia y plan de acción regionales sobre nutrición y desarrollo, 2006-2015. Washington; 2006. Reporte Nº CD47/18.
Unicef. Estadísticas de los indicadores nutricionales en Colombia. [citado marzo 2010]. Disponible en: http://www.unicef.org/spanish/infobycountry/colombia_statistics.html #64.
ICBF, Profamilia, Instituto Nacional de Salud, Universidad de Antioquia, OPS. Valoración del estado nutricional por indicadores antropométricos. En: Encuesta nacional de la situación nutricional en Colombia. Bogotá; 2011. p.88-9.
Alcaraz G, Bernal C. Estado nutricional y condiciones de vida de los niños y niñas menores de 5 años del área urbana del municipio de Turbo, Antioquia-Colombia, 2004. Biomédica. 2004;28:2-27.
Naciones Unidas. Objetivos de desarrollo del milenio. Informe de 2011. Nueva York; 2011. [citado abril 2012]. Disponible en: http://www.un.org/es/millenniumgoals/pdf/11-31342(S)MDG_Report_2011_Book_LR.pdf
Barker DJP. Fetal nutrition and cardiovascular disease in adult life. Lancet. 1993;341:938-41.
Eriksson JG, Forsen T, Toumilehto J, Winter PD, Osmond C, Barker DJP, et al. Catch-up growth in childhood and death from coronary heart disease: longitudinal study. BMJ. 1999;318:427-31.
Jiang Y, Zhang H, Sun T, Wang J, Sun W, Gong H, et al. The comprehensive effects of hyperlipidemia and hyperhomocysteinemia on pathogenesis of atherosclerosis and DNA hypomethylation in ApoE mice. Acta Biochim Biophys Sin. 2012;44:866-75.
Expert Panel on Detection, Evaluation and Treatment of High Blood Cholesterol in Adults. Executive summary of the third report of the National Cholesterol Education Program (NCEP) expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (Adult Treatment Panel III). JAMA. 2001;285:2486-97.
Carvajal I, Malavé I, Correa C, Castillo C, Pérez M, Hammar S, et al. Alteraciones de las fracciones lipídicas en el suero de niños desnutridos con y sin infección clínica: hipertrigliceridemia paradójica en desnutrición. Arch Latinoam Nutr. 1992;42:250-7.
Thanangkul U, Damrongsak D, Vithagasai V, Olson R. Clinical aspects of protein deficiency with special reference to protein calorie malnutrition (PCM) in children. J Nutr Sci Vitaminol. 1980;26:189-208.
Etukudo MH, Agbedana EO. Plasma electrolytes, total cholesterol, liver enzymes, and selected antioxidant status in protein energy malnutrition. Afr J Med Sci. 1999;28:81-5.
Feillet F, Parra H. Lipoprotein metabolism in marasmic children of Northern Mauritania. Am J Clin Nutr. 1993;58:484-8.
Díaz S, Velasco R, Berganza E. Perfil lipídico en desnutrición infantil. Pediatr. 1999;2:58-61.
Uscategui R, Álvarez MC. Factores de riesgo cardiovascular en niños de 6 a 18 años de Medellín (Colombia). An Pediatr. 2003;58:411-7.
Dini E, Arenas O. Pruebas de laboratorio en niños con desnutrición aguda moderada. An Venez Nutr. 2002;15:67-75.
Sawaya A, Martins P, Hoffman D, Roberts S. The link between childhood undernutrition and risk of chronic diseases in adulthood: a case study of Brazil. Nutr Rev. 2003;61:168-75.
Akuyam S, Isah H, Ogala W. Serum lipid profile in malnourished Nigerian children in Zaria. Niger Postgrad Med J. 2008;15:192-6.
Veiga G, Ferreira H, Sawaya A, Calado J, Florencio T. Dyslipidaemia and undernutrition in children from impoverished areas of Maceió, state of Alagoas, Brazil. Int J Environ Res Public Health. 2010;7:4139-51.
Ashwort A, Khanum S, Jackson A, Schofield C. Guidelines for the inpatient treatment of severely malnourished children.Geneve: OMS; 2003.
National Cholesterol Education Program (NCEP). Rationale for attention to cholesterol levels in children and adolescents. Pediatrics. 1992;89 (Suppl 3):528-7.
Parra Gámez L, Téllez Girón J, Briones C. La desnutrición y sus consecuencias sobre el metabolismo intermedio. Rev Fac Med UNAM. 2003;46:32-6.
Akuyam S; Isah H, Ogala W. Relationship between age and serum lipids in malnourished and well-fed pre-school children in Zaria, Nigeria. Niger J Clin Pract. 2009;12:273-6.
Akuyam S, Isah H, Ogala W. Evaluation of serum lipid profile of under-five Nigerian children. Ann Afr Med. 2007;7:119-23.
Houssaini S. Lipids, lipoproteins, and fatty acids during infantile marasmus in the F&S area of Morocco. Biomed Pharmacother. 1999; 53:278-83.
Taiwo OO, Thomas KD. Plasma biochemical parameters in Nigerian children with protein energy malnutrition. East Afr Med J. 1992;69:428-32.
Badaloo A, Reid M. Relation between liver fat content and the rate of VLDL apolipoprotein B-100 synthesis in children with protein-energy malnutrition. Am J Clin Nutr. 2005;81:1126-32.
Eriksson JG, Forsén T, Tuomilehto J, Winter PD, Osmond C, Barker DJP. Catch-up growth in childhood and death from coronary heart disease: longitudinal study. BMJ. 1999;318:427-31.
Fernald L, Gertler P, Hou X. Cash component of conditional cash transfer program is associated with higher body mass index and blood pressure in adults. J Nutr. 2008;138:2250-57.
Duran P. Nutrición temprana y enfermedades en la edad adulta: acerca de la “hipótesis de Barker”. Arch Argent Pediatr. 2004;102:26-34.
American Academy of Pediatrics. Committee on Nutrition. Cholesterol in childhood. Pediatrics. 1998;101:141-7.
US. Preventive Services Task Force. Screening for lipid disorders in children: recommendation statement. Pediatrics. 2007;120:215-9.
Colombia. Ministerio de la Protección Social. Situación de salud en Colombia: indicadores básicos. Bogotá. [citado abril 2010]. Disponible en: http://www.minsalud.gov.co/salud/Paginas/INDICADORESBASICOSSP.aspx
Dirección Seccional de Salud de Antioquia. Mortalidad general por grupo edad según regiones y municipios: 2010. Medellín;2011. [citado marzo 2010]. Disponible en: http://www.dssa.gov.co/index.php/estadisticas/mortalidad
Muzzo S. Evolución de los problemas nutricionales en el mundo. El caso de Chile. Rev Chil Nutr. 2002;29:78-85.
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