Proteínas relacionadas con el metabolismo del hierro corporal

  • Vanessa Corrales Agudelo Vidarium, Centro de Investigación en Nutrición, Salud y Bienestar, Grupo Empresarial Nutresa
  • Beatriz Elena Parra Sosa Universidad de Antioquia
  • Luis Carlos Burgos Herrera Universidad de Antioquia
Palabras clave: hierro, proteínas de unión al hierro, expresión génica, oxidación-reducción, homeostasis, deficiencia de hierro

Resumen

Antecedentes: el hierro es uno de los minerales más estudiados; existe amplia información en cuanto a su metabolismo, función, interacciones y regulación; sin embargo, los estudios y análisis realizados se basan en proteínas específicas y pocos integran, en un solo texto, las características de estas moléculas relacionadas con el metabolismo del hierro corporal. Objetivo: profundizar en los aspectos moleculares, metabólicos y de modulación de las proteínas que participan en la homeostasis del hierro y en sus interacciones. Materiales y métodos: se hizo una búsqueda sistemática de información en bases de datos científicas de artículos sobre el tema, publicados entre 2006 y 2016. Resultados: la homeostasis del hierro corporal, es un proceso complejo y altamente regulado por diferentes moléculas que participan de manera integrada en su metabolismo; en los últimos años han surgido nuevas proteínas, algunas de ellas participan en el transporte de otros nutrientes y se les ha encontrado relación con el control humoral y celular del hierro; además, involucran la participación de varios órganos, tejidos y sistemas. Esta revisión incluye proteínas encargadas de facilitar el aprovechamiento biológico del nutriente, así como aquellas que protegen a las células de toxicidad por exceso de este mineral.

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Biografía del autor/a

Vanessa Corrales Agudelo, Vidarium, Centro de Investigación en Nutrición, Salud y Bienestar, Grupo Empresarial Nutresa

Máster en Nutrición y Metabolismo. Magister en Ciencias Básicas Biomédicas, énfasis en Bioquímica Nutricional. Nutricionista Dietista

 

Beatriz Elena Parra Sosa, Universidad de Antioquia

Maestría en Ciencias Básicas Biomédicas. Línea Bioquímica Nutricional. Nutricionista Dietista. Profesora Escuela de Nutrición y Dietética, Universidad de Antioquia; investigadora Línea Materno Infantil.

Luis Carlos Burgos Herrera, Universidad de Antioquia

Magíster en Bioquímica. Universidad de Antioquia. Médico

Citas

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Publicado
2017-05-10
Cómo citar
Corrales Agudelo V., Parra Sosa B. E., & Burgos Herrera L. C. (2017). Proteínas relacionadas con el metabolismo del hierro corporal. Perspectivas En Nutrición Humana, 18(1), 95-116. https://doi.org/10.17533/udea.penh.v18n1a08
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