Relationship between C - reactive protein and blood lipids assessed in children participating in a Food Complement Program, alliance MANA-ICBF. Antioquia-Colombia
DOI:
https://doi.org/10.17533/udea.penh.9364Keywords:
C-Reactive protein, lipids, hyperlipidemias, risk factors, nutrition programmes, children, ColombiaAbstract
Background: the C-Reactive protein (CRP) is a biomarker for systemic disease that is considered in recent years as an emerging risk factor for cardiovascular disease in adults. Few studies conducted in children have assessed the C - reactive protein and blood lipids. Objective: to determine the association between CRP and blood lipids in children participating in a Food Complement Program, alliance MANA-ICBF. Antioquia-Colombia. Methodology: this is a cross sectional analytical study. Population and sample: 2.754 low income children were recruited from the research “Social and economic context, nutritional status, health conditions and food intake participating in a food complement program alliance MANA and ICBF. Antioquia-Colombia”, the sample for this study consisted of 201 children with high CRP levels and 201 children with normal CRP. Results: he mean and the median of high-density lipoprotein cholesterol (HDL) was low for children with highest levels of CRP (p=0,034). Children with high CRP, shown elevated relation of TC/HDL-C (OR=1.8) CI 95% [1, 03-3, 16], p =0,037 compared to children with normal CRP. Conclusion: children with high levels of CRP are more feasible to have high TC/HDL-c ratio, that is considered a risk factor for cardiovascular disease.
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Uscátegui RM, Álvarez MC, Laguado I, Soler W, Martínez M, Arias R, et al. Factores de riesgo cardiovascular en niños de 6 a 18 años de Medellín Colombia. An Pediatr. 2003; 58:411-17.
Velásquez E, Barón MA, Solano L, Páez M, Llovera D, Portillo Z. Perfil lipídico en preescolares venezolanos según nivel socioeconómico. Arch Latinoamer Nutr. 2006;56:22-8.
Rosillo D, Pituelli N, Corbera M, Lioi S, Turco M, Arrigo MD, et al. Perfil lipídico en niños y adolescentes de una población escolar. Arch Argent Pediatr. 2005;103:293-97.
Muennig P, Sohler N, Mahato B. Socioeconomic status as an independent predictor of physiological biomarkers of cardiovascular disease: evidence from NHANES. Prev Med. 2007;45:35-40.
Kaplan GA, JE K. Socioeconomic factors and cardiovascular disease: a review of the literature. Circulation. 1993;88:1973-88.
Carson AP, Rose KM, Catellier DJ, Kaufman JS, Wyatt SB, Diez-Roux AV, et al. Cumulative socioeconomic status across the life course and subclinical atherosclerosis. Ann Epidemiol. 2007;17:296-303.
Alvarez MC, López A, Monsalve J, Giraldo N, Zapata O, Vélez O, et al. Contexto sociodemográficos, estado nutricional e ingesta dietética de los niños usuarios del programa de complementación alimentaria de MANA. Medellín: Divergrafícas; 2007.
Ford ES, Giles WH, Myers GL, Rifai N, Ridker PM, Mannino DM. C-Reactive Protein concentration distribution among US Children and young adults: findings from the national Health and Nutrition Examination Survey, 1999–2000. Clin Chem. 2003;49:1353-7.
Ford ES. C-Reactive protein concentration and cardiovascular disease risk factors in children: findings from the National Health and Nutrition Examination Survey 1999-2000. Circulation. 2003;108:1053-8.
Woloshin S, Schwartz LM. Distribution of C-Reactive protein values in the United States. N Engl J Med. 2005;352:1611-2.
El-Hazmi M, Warsy A. Prevalence of plasma lipid abnormalities in Saudi children. Ann Saudi Med. 2001;21:21-5.
Hirschfield G, Pepys M. C-reactive protein and cardiovascular disease: new insights from an old molecule. Q J Med. 2003;96:793-807.
Wu DM, Chu NF, Shen MH, Chang JB. Plasma C-reactive protein levels and their relationship to anthropometric and lipid characteristics among children. J Clin Epidemiol. 2003;56:94-100.
Jarvisalo MJ, Harmoinen A, Hakanen M, Paakkunainen U, Viikari J, Hartiala J, et al. Elevated serum C-reactive protein levels and early arterial changes in healthy children. Arterioscler Thromb Vasc Biol. 2002;22:1323-8.
Daniels SR, Arnnett DK, RH. E, Gidding SS, Hayman LL, Kumanyika S, et al. Overweight in children and adolescents: pathophysiology, consequences, prevention, and treatment. Circulation. 2005;111:1999-2012.
Manios Y, Dimitriou M, Moschonis G, Kocaoglu B, Sur H, Keskin Y, et al. Cardiovascular disease risk factors among children of different socioeconomic status in Istanbul, Turkey: directions for public health and nutrition policy. Lipids Health Dis. 2004;3:11.
Antioquia. Dirección Seccional de Salud de Antioquia. Indicadores básicos: 2005. Medellín; 2006.
Gidding SS, Dennison BA, Birch LL, Daniels SR, Gilman MW, Lichtenstein AH, et al. Dietary recommendations for children and adolescents. a guide for practitioners: consensus statement from the American Heart Association. Circulation. 2005;112: 2061-75.
National Committee for Clinical Laboratory Standards. Precision performance of clinical chemistry devices, tentative guideline. 2nd ed. Villanova, PA: NCCLS; 1992. NCCLS publication EP5-T2.
National Cholesterol Education Program Expert Panel. Executive summary of the third report of the Expert Panel on detection, evaluation and treatment of high blood cholesterol in adults (Adult Treatment Panel III). JAMA 2001;285:2486-97.
Meiattini F, Prencipe L, Bardelli F, Giannini G, Tarli P. The 4-hydroxybenzoate/4-aminophenazone chromogenic system used in the enzymic determination of serum cholesterol. Clin Chem. 1978;24:2161-5.
Fossati P, Prencipe L. Serum triglycerides determined colorimetrically with an enzime that produces hydrogen peroxide. Clin Chem. 1982;28:2077-2080.
Warnick G, Nauck M, Rifai N. Evolution of methods for measurement of HDL-cholesterol: for ultracentrifugation to homogeneous assays. Clin Chem. 2001;47:1579-96.
National Cholesterol Education Program. Report of the Expert Panel on Blood Cholesterol Levels in Children and Adolescents. Washington, DC: National Institutes of Health; 1991. Publication no. 91-2732.
Castelli WP, Fernández-Cruz A. Recomendaciones de ILIB para el diagnóstico de las dislipidemias en Latinoamérica. Cardiovas Risk Fact. 1994;3(Suppl 1):10-27.
Lambert M, Delvin EE, Paradis G, O’Loughlin J, Hanley J, Levy H. C-Reactive protein and features of the metabolic syndrome in a population-based sample of children and adolescents. Clin Chem. 2004;50:1762-68.
Wu DM, Chu NF, Shen MH, Wang SC. Obesity, plasma high sensitivity c-reactive protein levels and insulin resistance status among school children in Taiwan. Clin Biochem. 2006;39:810-15.
Ford ES, Ajani UA, Mokdad AH. The metabolic syndrome and concentrations of C-Reactive protein among U.S. Youth. Diabetes Care. 2005;28:878-81.
Moran A, Steffen LM, Jacobs DR, Jr., Steinberger J, Pankow JS, Hong CP, et al. Relation of C-reactive protein to insulin resistance and cardiovascular risk factors in youth. Diabetes Care. 2005;28:1763-8.
Ballantyne CM, Hoogeveen RC. Role of lipid and lipoprotein profiles in risk assessment and therapy. Am Heart J. 2003;146: 227-33.
Morales MM, Medina CE, Lara L. Estudio del perfil lipídico en niños y adolescentes descendientes de padres con o sin antecedentes patológicos cardiovasculares. Bol Med Postgrado. 2001;17:206-13.
Moura EC, Castro CM, Mellin AS, Figueiredo DB. Perfil lipídico em escolares de Campinas, SP, Brasil. Rev Saúde Pública. 2000;34:499-505.
Prieto L, Arroyo J, Vadillo M, Mateos C, Galán A. Prevalencia de hiperlipidemia en niños y adolescentes de la provincia de Cáceres. Rev Esp Salud Pública. 1998;4:343-55.
Alissa EM, Bahjri SM, Al-Ama N, Ahmed WH, Ferns GA. High cardiovascular risk in young Saudi males: cardiovascular risk factors, diet and inflammatory markers. Clin Chim Acta. 2006;365:288-96.
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